Andrew Zachary Fire (born April 27, 1959) is an American

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter ...

and professor of pathology and of genetics at the Stanford University School of Medicine. He was awarded the

2006 Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordin ...

, along with Craig C. Mello, for the discovery of

RNA interference RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by ...

(RNAi). This research was conducted at the

Carnegie Institution of Washington The Carnegie Institution of Washington (the organization's legal name), known also for public purposes as the Carnegie Institution for Science (CIS), is an organization in the United States established to fund and perform scientific research. Th ...

and published in 1998.

Biography

Andrew Fire was born in

Palo Alto, California Palo Alto (; Spanish for "tall stick") is a charter city in the northwestern corner of Santa Clara County, California, United States, in the San Francisco Bay Area, named after a coastal redwood tree known as El Palo Alto. The city was es ...

and raised in Sunnyvale, California. He graduated from Fremont High School. He attended the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

for his undergraduate degree, where he received a

B.A. Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four yea ...

in mathematics in 1978 at the age of 19. He then proceeded to the

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

, where he received a

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

in biology in 1983 under the mentorship of Nobel laureate

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...

Phillip Sharp Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryo ...

. Fire moved to

Cambridge Cambridge ( ) is a College town, university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cam ...

, England, as a Helen Hay Whitney Postdoctoral Fellow. He became a member of the MRC

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

group headed by Nobel laureate biologist

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

. From 1986 to 2003, Fire was a staff member of the

’s Department of

Embryology Embryology (from Greek ἔμβρυον, ''embryon'', "the unborn, embryo"; and -λογία, ''-logia'') is the branch of animal biology that studies the prenatal development of gametes (sex cells), fertilization, and development of embryos ...

Baltimore Baltimore ( , locally: or ) is the List of municipalities in Maryland, most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic (United States), Mid-Atlantic, and List of United States cities by popula ...

Maryland Maryland ( ) is a state in the Mid-Atlantic region of the United States. It shares borders with Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean to ...

. The initial work on double stranded RNA as a trigger of gene silencing was published while Fire and his group were at the Carnegie Labs. Fire became an adjunct professor in the Department of Biology at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consi ...

in 1989 and joined the Stanford faculty in 2003. Throughout his career, Fire has been supported by research grants from the U.S.

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

. Fire is a member of the National Academy of Sciences and the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

. He also serves on the Board of Scientific Counselors and the National Center for Biotechnology, National Institutes of Health.

Nobel Prize

In 2006, Fire and Craig Mello shared the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

for work first published in 1998 in the journal ''

Nature Nature, in the broadest sense, is the physical world or universe. "Nature" can refer to the phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. Although humans are ...

''. Fire and Mello, along with colleagues SiQun Xu, Mary Montgomery, Stephen Kostas, and Sam Driver, reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA cannot be translated into protein. Fire and Mello found that dsRNA was much more effective in gene silencing than the previously described method of RNA interference with single-stranded RNA. Because only small numbers of dsRNA molecules were required for the observed effect, Fire and Mello proposed that a catalytic process was involved. This hypothesis was confirmed by subsequent research. The Nobel Prize citation, issued by Sweden's

Karolinska Institute The Karolinska Institute (KI; sv, Karolinska Institutet; sometimes known as the (Royal) Caroline Institute in English) is a research-led Medical school, medical university in Solna Municipality, Solna within the Stockholm urban area of Sweden. ...

, said: "This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information." The

British Broadcasting Corporation #REDIRECT BBC #REDIRECT BBC #REDIRECT BBC Here i going to introduce about the best teacher of my life b BALAJI sir. He is the precious gift that I got befor 2yrs . How has helped and thought all the concept and made my success in the 10th board ex ...

(BBC) quoted Nick Hastie, director of the Medical Research Council's Human Genetics Unit, on the scope and implications of the research:

Awards and honors

Fire has received the following awards and honors:
(By chronological year of award ) *

Meyenburg Prize The Meyenburg Prize is awarded for outstanding achievements in cancer research by the Meyenburg Foundation in support of the German Cancer Research Center, Heidelberg (DKFZ), which is the largest biomedical research institution in Germany. The pri ...

in 2002 * Co-recipient (with

Craig Mello Craig Cameron Mello (born October 18, 1960) is an American biologist and professor of molecular medicine at the University of Massachusetts Medical School in Worcester, Massachusetts. He was awarded the 2006 Nobel Prize for Physiology or Medicine, ...

) of National Academy of Sciences Award in Molecular Biology in 2003 * Co-recipient (with Craig Mello, Thomas Tuschl and

David Baulcombe Sir David Charles Baulcombe One or more of the preceding sentences incorporates text from the royalsociety.org website where: (born 1952) is a British plant scientist and geneticist. he is a Royal Society Research Professor and Regius Profe ...

) of the

Wiley Prize The Wiley Prize in Biomedical Sciences is intended to recognize breakthrough research in pure or applied life science research that is distinguished by its excellence, originality and impact on our understanding of biological systems and processes. ...

in the Biomedical Sciences from Rockefeller University in 2003 * Elected member National Academy of Sciences in 2004 * Co-recipient (with

Victor Ambros Victor R. Ambros (born 1953, Hanover, New Hampshire) is an American developmental biologist who discovered the first known microRNA (miRNA). He is a professor at the University of Massachusetts Medical School in Worcester, Massachusetts. Back ...

, and

Gary Ruvkun Gary Bruce Ruvkun (born March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which ''lin-4'', th ...

) of

Brandeis University , mottoeng = "Truth even unto its innermost parts" , established = , type = Private research university , accreditation = NECHE , president = Ronald D. Liebowitz , ...

's Lewis S. Rosenstiel Award for Distinguished Work in Medical Research in 2005 * Co-recipient (with Craig Mello) of the

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...

in 2005 * Co-recipient (with Craig Mello and

) of the

Massry Prize The Massry Prize was established in 1996, and until 2009 was administered by the Meira and Shaul G. Massry Foundation. The Prize, of $40,000 and the Massry Lectureship, is bestowed upon scientists who have made substantial recent contributions in ...

in 2005 * Co-recipient (with Craig Mello) of the

Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for investigations in medicine. It carries a prize money of 120,000 Euro. The prize awarding ceremony is traditionally held on March 14, the birthday of N ...

in 2006 * Co-recipient (with Craig Mello) of the

in 2006

References

External links

* including the Nobel Lecture ''Gene Silencing by Double Stranded RNA''
Nobel Prize press release

Carnegie Institution for Science

* [https://web.archive.org/web/20061102223642/http://www.umassmed.edu/administration/uploads/Fire_and_Mello_Nature_1998.pdf Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans], in ''

'', via

University of Massachusetts Medical School The University of Massachusetts Chan Medical School is a public medical school in Worcester, Massachusetts. It is part of the University of Massachusetts system. It is home to three schools: the T.H. Chan School of Medicine, the Morningside Grad ...

{{DEFAULTSORT:Fire, Andrew 1959 births Living people Nobel laureates in Physiology or Medicine American Nobel laureates Members of the European Molecular Biology Organization American geneticists Jewish geneticists Jewish American scientists Johns Hopkins University faculty Massachusetts Institute of Technology School of Science alumni University of California, Berkeley alumni People from Palo Alto, California Members of the United States National Academy of Sciences Stanford University School of Medicine faculty Winners of the Heineken Prize People from Sunnyvale, California Massry Prize recipients Fellows of the American Academy of Arts and Sciences Fellows of the AACR Academy People from Stanford, California Members of the National Academy of Medicine

Biography

Nobel Prize

Awards and honors

See also

References

External links