Alternative vaccination schedule
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An alternative vaccination schedule is a
vaccination schedule A vaccination schedule is a series of vaccinations, including the timing of all doses, which may be either recommended or compulsory, depending on the country of residence. A vaccine is an antigenic preparation used to produce active immunity to ...
differing from the schedule endorsed by the
Advisory Committee on Immunization Practices The Advisory Committee on Immunization Practices (ACIP) is a committee within the United States Centers for Disease Control and Prevention (CDC) that provides advice and guidance on effective control of vaccine-preventable diseases in the U.S. c ...
(ACIP). These schedules may be either written or ''
ad hoc Ad hoc is a Latin phrase meaning literally 'to this'. In English, it typically signifies a solution for a specific purpose, problem, or task rather than a generalized solution adaptable to collateral instances. (Compare with '' a priori''.) C ...
'', and have not been tested for their safety or efficacy. Proponents of such schedules aim to reduce the risk of adverse effects they believe to be caused by vaccine components, such as " immune system overload" that is argued to be caused by exposure to multiple
antigen In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune respons ...
s. Parents who adopt these schedules tend to do so because they are concerned about the potential risks of vaccination, rather than because they are unaware of the significance of vaccination's benefits. Delayed vaccination schedules have been shown to lead to an increase in breakthrough infections without any benefit in lower side effect profiles.Kroger A, Bahta L, Hunter P
Best Practices Guidance of the Advisory Committee on Immunization Practices (ACIP)


Effects

Contrary to the claims made by some advocates of alternative vaccine schedules, there is no scientific evidence for the existence of "immune system overload", and according to the UK
National Health Service The National Health Service (NHS) is the umbrella term for the publicly funded healthcare systems of the United Kingdom (UK). Since 1948, they have been funded out of general taxation. There are three systems which are referred to using the " ...
the idea is a "myth". In addition, the amount of chemicals in vaccines such as
aluminium Aluminium (aluminum in American and Canadian English) is a chemical element with the symbol Al and atomic number 13. Aluminium has a density lower than those of other common metals, at approximately one third that of steel. I ...
and
formaldehyde Formaldehyde ( , ) (systematic name methanal) is a naturally occurring organic compound with the formula and structure . The pure compound is a pungent, colourless gas that polymerises spontaneously into paraformaldehyde (refer to section ...
is much lower than natural exposure levels. Intentional deviation from the ACIP's schedule leaves children vulnerable to infection and increases the likelihood of outbreaks of vaccine-preventable diseases. These schedules also increase the chances of infection among individuals who could not be vaccinated for medical reasons, because they were too young, or who did not develop a sufficient immunologic response to the vaccine. After one of the most notorious outbreaks of measles in the
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...
, in
California California is a state in the Western United States, located along the Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the most populous U.S. state and the 3rd largest by area. It is also the m ...
, legislation was passed to make vaccination mandatory, as alternative vaccine scheduling and/or avoidance had been prevalent before the outbreak.


Popularity

An increasing number of children are undervaccinated, of whom an estimated 13% or more are believed to be so because of parental choice. One survey, published in ''Vaccine'', found that 9.4% of parents in
King County, Washington King County is located in the U.S. state of Washington. The population was 2,269,675 in the 2020 census, making it the most populous county in Washington, and the 13th-most populous in the United States. The county seat is Seattle, also the ...
used an alternative vaccine schedule, while another survey found that more than 1 out of 10 parents of children aged between 6 months and 6 years used an alternative vaccine schedule. In a 2011 survey of Washington State pediatricians, 77% of them reported that their patients "sometimes or frequently" asked for alternative vaccination schedules. The same survey found that 61% of pediatricians were comfortable with using such a schedule if a parent asked for it. A 2012 survey found that the percentage of shot-limiting children—defined as children who received no more than two vaccines per visit between their birth and the age of nine months—had increased from 2.5% to 9.5% in
Portland, Oregon Portland (, ) is a port city in the Pacific Northwest and the list of cities in Oregon, largest city in the U.S. state of Oregon. Situated at the confluence of the Willamette River, Willamette and Columbia River, Columbia rivers, Portland is ...
. Research on well-off American families suggests that even parents who are ostensibly pro-vaccine can be misled by disinformation, and this can lead them to delay having their children vaccinated, and to tolerate such delay in others.


Proponents

Among the most prominent proponents of alternative vaccination schedules is notable pediatrician and vaccine critic Robert Sears. Sears has been criticized by vaccine expert
Paul Offit Paul Allan Offit (born March 27, 1951) is an American pediatrician specializing in infectious diseases, vaccines, immunology, and virology. He is the co-inventor of a rotavirus vaccine. Offit is the Maurice R. Hilleman Professor of Vaccinology, ...
for what Offit states is Sears' "misrepresentation of vaccine science." Offit argues that Sears' alternative vaccination schedules present a public health risk, in that Sear's alternative vaccination schedules require a larger number of visits to the doctors office for parents - and unvaccinated children can acquire transmissible diseases while waiting in doctors offices'. Furthermore, increasing the time before a child receives a vaccine will increase the time in which that child is vulnerable to contracting preventable diseases. Additionally, spreading out vaccination shots does not decrease a child's pain or anxiety related to the shot: in fact, increasing a child's total amount of doctor visits for vaccination shots (by insisting upon a single shot per visit) may increase that child's needle phobia, according to Dr. Offit. Overall, Sears' alternative vaccination schedules are likely to decrease immunization rates by reducing vaccine timeliness. Notably, Sears has responded to Offit's critique by conceding many of his original positions - in other words, Sears has since stated that he is in favour of the conventional vaccine schedule, and that many of his original positions (e.g., that thimerosal causes autism) are not supported by evidence. Likewise, the American Academy of Pediatricians has stated that no alternative vaccine schedules have been found to provide better safety or efficacy than the recommended vaccination schedule. In June 2018, the
Medical Board of California The Medical Board of California (MBC) is a state government agency which licenses and disciplines physicians, surgeons and certain allied healthcare professionals in California. The Board provides two principal types of services to consumers: (1) ...
placed Sears on probation for improperly granting a medical exemption from all future vaccines to a two-year-old child without obtaining any of the child's medical records, including which vaccines the child had received to date.


Types of schedules

A 2016 study identified five different types of alternative vaccine schedules: Sears' schedule, a shot-limiting schedule, selective delaying or refusal, making vaccine decisions visit-by-visit, or refusing all vaccines. Regardless of the type of alternative schedule used, skipping or delaying recommended vaccines has been shown to result in an increased risk of contracting and spreading
vaccine-preventable diseases A vaccine-preventable disease is an infectious disease for which an effective preventive vaccine exists. If a person acquires a vaccine-preventable disease and dies from it, the death is considered a vaccine-preventable death. The most common and s ...
.


See also

*
MMR vaccine and autism Claims of a link between the MMR vaccine and autism have been extensively investigated and found to be false. The link was first suggested in the early 1990s and came to public notice largely as a result of the 1998 ''Lancet'' MMR autism frau ...
*
Vaccine hesitancy Vaccine hesitancy is a delay in acceptance, or refusal, of vaccines despite the availability of vaccine services and supporting evidence. The term covers refusals to vaccinate, delaying vaccines, accepting vaccines but remaining uncertain abou ...


References


Further reading

* {{Vaccine safety Vaccine hesitancy