Allopumiliotoxin 267A is a toxin found in the skin of several poison frogs of the family ''

Dendrobates ''Dendrobates'' is a genus of poison dart frogs native to Central and South America. It once contained numerous species, but most originally placed in this genus have been split off into other genera such as ''Adelphobates'', '' Ameerega'', '' A ...

''. It is a member of the class of compounds known as

allopumiliotoxin Allopumiliotoxins are a structural division in the pumiliotoxin-A class of alkaloids. The compounds of the pumiliotoxin-A class are primarily found in the skins of frogs, toads, and other amphibians and are used as a chemical defense mechanism to ...

s. The frogs produce the toxin by modifying the original version,

pumiliotoxin 251D Pumiliotoxin 251D is a toxic organic compound. It is found in the skin of poison frogs from the genera ''Dendrobates'', ''Epipedobates'', '' Minyobates'', and ''Phyllobates'' and toads from the genus '' Melanophryniscus''. Its name comes from the ...

. It has been tested on mice and found to be five times more potent than the former version. It has been produced synthetically through a variety of different routes.

References

{{Poison frog alkaloids Vertebrate toxins Alkaloids Ion channel toxins Vicinal diols

See also

References