Allenolic acid, or allenoic acid, is a synthetic,

nonsteroidal A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents. List of nonsteroidal steroid receptor mo ...

estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal ac ...

discovered in 1947 or 1948 that, although studied clinically, was never marketed. It is an open-ring or seco- analogue of steroidal estrogens like

estrone Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized ...

and equilenin. The compound was named after

Edgar Allen Edgar Allen (May 2, 1892 – February 3, 1943) was an American anatomist and physiologist. He is known for the discovery of estrogen and his role in creating the field of endocrinology. Born on Cañon (Canyon) City, Colorado, Allen was educate ...

, one of the pioneers in estrogen research. Although described as an estrogen, allenolic acid probably is totally inactive at the receptor, whereas a derivative,

allenestrol Allenestrol, or allenoestrol, also known as α,α-dimethyl-β-ethylallenolic acid or as methallenestrilphenol, is a synthetic, nonsteroidal estrogen and a derivative of allenolic acid that was never marketed. A methyl ether of allenestrol, methall ...

(α,α-dimethyl-β-ethylallenolic acid), is reported to be a potent estrogen. Another derivative of allenolic acid (specifically 6-

methoxy In organic chemistry, a methoxy group is the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula . On a benzene ring, the Hammett equation classifies a methoxy substituent at the ''para'' position a ...

-allenestrol),

methallenestril Methallenestril () (brand names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril), also known as methallenoestril () and as methallenestrol, as well as Horeau's acid, is a synthetic nonsteroidal estrogen and a derivative of allenolic acid and ...

(brand name Vallestril), is also a potent estrogen and, in contrast to allenolic acid and allenestrol, has been marketed.

References

2-Naphthols Propionic acids Synthetic estrogens {{genito-urinary-drug-stub

See also

References