Prohibitin-targeting peptide 1 (also known as prohibitin-TP01 and TP01; trade name Adipotide) is a peptidomimetic with Peptide sequence, sequence CKGGRAKDC-GG-
D(KLAKLAK)
2. It is an experimental proapoptotic drug that has been shown to cause rapid weight loss in mice
and rhesus monkeys.
Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis.
TP01 is designed to bind to two receptors, ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.
As of 2019, clinical development has been discontinued.
References
{{Extracellular chemotherapeutic agents
Angiogenesis inhibitors
Experimental anti-obesity drugs
Receptor antagonists
Abandoned drugs