Acetryptine (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
) (developmental code name W-2965-A), also known as 5-acetyltryptamine (5-AT),
is a
drug described as an
antihypertensive agent which was never marketed.
Structurally, acetryptine is a
substituted tryptamine, and is closely related to other substituted tryptamines like
serotonin (5-hydroxytryptamine).
It was developed in the early 1960s.
The
binding of acetryptine to
serotonin receptors does not seem to have been well-investigated, although it was assessed at the
5-HT1A and
5-HT1D receptors and found to bind to them with high
affinity
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.
The drug may also act as a
monoamine oxidase inhibitor (MAOI); specifically, as an
inhibitor of
MAO-A
Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the ''MAOA'' gene. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, s ...
.
See also
*
5-Benzyloxytryptamine
*
5-Carboxamidotryptamine
*
5-Ethoxy-DMT
5-Ethoxy-DMT (5-ethoxy-''N'',''N''-dimethyltryptamine, 5-EtO-DMT, ''O''-ethylbufotenine) is a tryptamine derivative which has been previously synthesized as a chemical intermediate, but has not been studied to determine its pharmacology.
The wid ...
*
5-Methoxytryptamine
*
5-(Nonyloxy)tryptamine
5-(Nonyloxy)tryptamine is a tryptamine derivative which acts as a selective agonist at the 5-HT1B receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT1B, with highest activity ...
*
Azepindole
Azepindole (McN-2453) is a tricyclic compound with antidepressant and antihypertensive effects that was developed in the late 1960s but was never marketed.
See also
* Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class o ...
*
Indorenate
Indorenate (TR-3369), is a tryptamine derivative which acts as an agonist at the 5-HT1A, 5-HT1B and 5-HT2C serotonin receptors. It has anxiolytic, antihypertensive and anorectic effects, predominantly through action at 5-HT1A, but with some ...
*
Metralindole
*
Pargyline
Pargyline (brand name Eutonyl) is an irreversible selective monoamine oxidase (MAO)-B inhibitor drug ( IC50 for MAO-A is 0.01152 μmol/L and for MAO-B is 0.00820 μmol/L) It was brought to market in the US and the UK by Abbott in 1963 as an ...
*
Pirlindole
*
Sumatriptan
*
Tetrindole
References
Antihypertensive agents
Serotonin receptor agonists
Tryptamines
{{antihypertensive-stub