Accelerated phase chronic myelogenous leukemia is a phase of
chronic myelogenous leukemia in which the disease is progressing.
In this phase, 10 to 19% of the cells in the
blood
Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the cir ...
and
bone marrow are
blast cell
In cell biology, a precursor cell, also called a blast cell or simply blast, is a partially differentiated cell, usually referred to as a unipotent cell that has lost most of its stem cell properties. A precursor cell is also known as a proge ...
s (
immature
Mature is the adjectival form of maturity, as immature is the adjectival form of immaturity, which have several meanings.
Mature or immature may also refer to:
* Mature, a character from ''The King of Fighters'' series
*"Mature 17+", a rating in ...
blood cells
A blood cell, also called a hematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found mainly in the blood. Major types of blood cells include red blood cells (erythrocytes), white blood cells (leukocytes), a ...
). In the accelerated phase, these leukemia cells grow quickly.
Symptoms
Common symptoms include
fever
Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...
,
bone pain
Bone pain (also known medically by several other names) is pain coming from a bone, and is caused by damaging stimuli. It occurs as a result of a wide range of diseases or physical conditions or both, and may severely impair the quality of life. ...
, and
swollen spleen.
Treatment
Patients treated with
imatinib,
dasatinib
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that ar ...
, and
nilotinib have shown meaningful rates of hematologic and cytogenetic response.
Prognosis
Prognosis is very poor once chronic myelogenous leukemia reaches the accelerated phase; it behaves similarly to
acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. Symptoms may inclu ...
.
References
External links
Accelerated phase chronic myelogenous leukemiaentry in the public domain NCI Cancer Dictionary
Chronic myeloid leukemia
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