AS-8112 is a synthetic compound that acts as a selective antagonist at the

dopamine receptor Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through diffe ...

subtypes D₂ and D₃, and the serotonin receptor 5-HT₃. It has potent

antiemetic An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. They m ...

effects in animal studies and has been investigated for potential medical use.

References

Antiemetics 5-HT3 antagonists Dopamine antagonists Bromoarenes Salicylamide ethers Diazepanes {{gastrointestinal-drug-stub