RefSeq (protein)



Location (UCSC) Chr 15: 74.54 – 74.6 Mb Chr 9: 57.79 – 57.84 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.[5]


This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.[5]


Further reading

  • Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570. 
  • Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID 10446990. 
  • Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. doi:10.1016/j.celrep.2015.12.064. PMID 26776511. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.