AM-1714 (part of the
AM cannabinoid series) is a drug that acts as a reasonably selective
agonist of the peripheral
cannabinoid receptor
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid recep ...
CB2, with sub-nanomolar affinity and 490x selectivity over the related
CB1 receptor. In animal studies it has both
analgesic and anti-
allodynia
Allodynia is a condition in which pain is caused by a stimulus that does not normally elicit pain. For example, bad sunburn can cause temporary allodynia, and touching sunburned skin, or running cold or warm water over it, can be very painful. It i ...
effects. The 9-methoxy derivative AM-1710 has similar CB
2 affinity but only 54x selectivity over CB
1.
See also
*
Cannabinol
Cannabinol (CBN) is a mildly psychoactive cannabinoid that acts as a low affinity partial agonist at both CB1 and CB2 receptors. This activity at CB1 and CB2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS).
CBN ...
*
Canbisol
References
AM cannabinoids
Benzochromenes
Coumarins
{{cannabinoid-stub