ALD-52
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ALD-52, also known as 1-
acetyl In organic chemistry, acetyl is a functional group with the chemical formula and the structure . It is sometimes represented by the symbol Ac (not to be confused with the element actinium). In IUPAC nomenclature, acetyl is called ethanoyl, ...
-LSD, is a chemical analogue of
lysergic acid diethylamide Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
(LSD). It was originally discovered by
Albert Hofmann Albert Hofmann (11 January 1906 – 29 April 2008) was a Swiss chemist known for being the first to synthesize, ingest, and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann's team also isolated, named and synthesi ...
in 1957 but was not widely studied until the rise in popularity of
psychedelics Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
in the 1960s.


Effects

In Entry 26 of his compendium '' TiHKAL'', which discussed LSD,
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...
Alexander Shulgin Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymetha ...
touched briefly on the subject of ALD-52. His comments there are vague, second-hand accounts saying doses in the 50–175 µg range have resulted in various conclusions. One account found that there was less visual distortion than with LSD and it seemed to produce less anxiety and tenseness and that it was somewhat less potent. Another informant claimed it was more effective in increasing
blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure ...
. Yet another informant could not tell them apart.


Safety

In ''The Hallucinogens'' by Hoffer and Osmond (1967), ALD-52 is listed as having a lower (approximately 1/5) ''
intravenous Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...
'' toxicity (in rabbits), a lower (approximately 1/8) pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD. Human experiments have not been well documented.


History

In a Reddit AMA with the director of the movie '' The Sunshine Makers'', Tim Scully says:
"The Orange Sunshine we delivered was LSD 25. ALD 52 was an ill-advised desperate defense strategy that failed miserably... The story of Orange Sunshine is complicated by the fact that The Brotherhood distributed LSD from more than one manufacturer as Orange Sunshine. "Nick and I made the original Orange Sunshine in Windsor. That was the last lab I worked in making LSD. Ron Stark managed several LSD labs in Europe and most of his output was tableted and sold as Orange Sunshine. At least some of the LSD that his labs made was not pure."
Tim Scully has confirmed that the speculation below is incorrect. The Orange Sunshine variety of LSD that was widely available in
California California is a state in the Western United States, located along the Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the most populous U.S. state and the 3rd largest by area. It is also the m ...
through 1968 and 1969 was produced in the
Sonoma County Sonoma County () is a county located in the U.S. state of California. As of the 2020 United States Census, its population was 488,863. Its county seat and largest city is Santa Rosa. It is to the north of Marin County and the south of Mendocino ...
underground chemistry lab of Tim Scully and Nicholas Sand. It was shut down by the police, and Scully was arrested and prosecuted. This resulted in the first drug analogue trial, where Scully claimed that he and his partners did nothing illegal, because they were producing ALD-52, which was not an
illicit drug The prohibition of drugs through sumptuary legislation or religious law is a common means of attempting to prevent the recreational use of certain intoxicating substances. While some drugs are illegal to possess, many governments regulate the ...
. However, as the prosecution claimed, there were problems with such a rationale—ALD-52 was claimed to readily undergo
hydrolysis Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution, elimination, and solvation reactions in which water is the nucleophile. Biological hydrolysi ...
to LSD, and secondly, the synthesis of ALD-52 required LSD. (The second point was based on the methods available in the scientific literature at the time). Scully was convicted and served time in prison.


Legal status


Austria

ALD-52 is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD


Denmark

ALD-52 is not listed as an illegal substance in Denmark as of April, 2019, and its chemical class 'lysergamide' is not banned under the Analogue Act (Some LSD analogues are, however, prohibited).


Finland

ALD-52 is labeled a controlled psychoactive substance in Finland as of 2014.


Germany

ALD-52 is controlled under the NpSG as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.


Latvia

ALD-52 is illegal in Latvia. Although it isn't officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.


Romania

1P-LSD is illegal to produce or sell in Romania. It is not included directly in the list of controlled substances, but it is included i
an analogue act
However, it is not, as of yet, classified as illegal to use.


Singapore

ALD-52 is a class A controlled drug, and is illegal to traffic, manufacture, import, export, possess, or consume in Singapore as of December 1, 2019, punishable with a minimum of five years’ imprisonment and five strokes of the cane.


Switzerland

Since March 2018, ALD-52 is illegal in Switzerland and has been put in th
RS 812.121.11


United Kingdom

On June 10, 2014 the UK
Advisory Council on the Misuse of Drugs The Advisory Council on the Misuse of Drugs (ACMD) is a British statutory advisory non-departmental public body, which was established under the Misuse of Drugs Act 1971. Mandate Its terms of reference, according to the Act, are as follows: '' ...
(ACMD) recommended that ALD-52 be specifically named in the UK Misuse of Drugs Act as a class A drug despite not identifying it as ever having been sold or any harm associated with its use. The UK Home office accepted this advice and announced a ban of the substance to be enacted on 6 January 2015 as part o
The Misuse of Drugs Act 1971 (Amendment) (No. 2) Order 2014


United States

ALD-52 is unscheduled in the United States. It may be considered an analogue of LSD, a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption or the use for illicit non-medical or scientific use could be prosecuted as crimes under the Federal Analogue Act however could be legal for medical and research uses like a
research chemical Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only; a research chemical is not intended for human o ...
.


See also

*
Lysergic acid diethylamide Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
(LSD) * 1cP-LSD * 1B-LSD * 1P-LSD * 1V-LSD * 1cP-AL-LAD *
AL-LAD AL-LAD, also known as 6-allyl-6-''nor''-LSD, is a psychedelic drug and an analog of lysergic acid diethylamide (LSD). It is described by Alexander Shulgin in the book '' TiHKAL'' (''Tryptamines i Have Known And Loved''). It is synthesized starti ...
*
ETH-LAD ETH-LAD, 6- ethyl-6-''nor''-lysergic acid diethylamide is an analogue of LSD. Its human psychopharmacology was first described by Alexander Shulgin in the book TiHKAL. ETH-LAD is a psychedelic drug similar to LSD, and is slightly more potent th ...
*
PRO-LAD PRO-LAD is an analogue of LSD. It is described by Alexander Shulgin in the book TiHKAL. PRO-LAD is a psychedelic drug similar to LSD, and is around as potent as LSD itself with an active dose reported at between 100 and 200 micrograms. Legal st ...
*
LSM-775 ''N''-Morpholinyllysergamide (LSM-775) is a derivative of ergine. It is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 700 micrograms and a shorter duration. There are fewer signs of cardiovascular ...
* LSZ * O-Acetylpsilocin (4-AcO-DMT)


References


External links


Entry #26 from TiHKAL

everything2

Lycaeum


{{Ergolines Lysergamides Euphoriants Psychedelic drugs Serotonin receptor agonists Entheogens Designer drugs Acetamides