ADP-ribosylation factor 6 (ARF6) is a member of the
ADP ribosylation factor
ADP ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily. ARF family proteins are ubiquitous in eukaryotic cells, and six highly conserved members of the family have been identified in mamm ...
family
Family (from la, familia) is a group of people related either by consanguinity (by recognized birth) or affinity (by marriage or other relationship). The purpose of the family is to maintain the well-being of its members and of society. Idea ...
of
GTP-binding protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their ac ...
s. ARF6 has a variety of cellular functions that are frequently involved in trafficking of
biological membranes and
transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequent ...
cargo. ARF6 has specifically been implicated in
endocytosis of
plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
Function
This gene encodes a member of the human ARF gene family, which is part of the
Ras superfamily
The Ras superfamily, derived from "Rat sarcoma virus", is a protein superfamily of small GTPases. Members of the superfamily are divided into families and subfamilies based on their structure, sequence and function. The five main families are Ra ...
. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A
pseudogene of this gene is located on chromosome 7.
ARF6 can interact with β
arrestin
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.
Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of ...
upon
receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
activation.
Interactions
ARF6 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
ARRB1
*
ARFIP2
Arfaptin-2 is a protein that in humans is encoded by the ''ARFIP2'' gene.
Interactions
ARFIP2 has been shown to interact with Arf6
ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding protei ...
*
CHRM3
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EXOC5
Exocyst complex component 5 is a protein that in humans is encoded by the ''EXOC5'' gene.
Function
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to ...
*
KIAA0090
*
Rac1
References
Further reading
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External links
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{{GTPases
Human proteins
Genes on human chromosome 14