AB-PINACA is a compound that was first identified as a component of
synthetic cannabis products in Japan in 2012.
It was originally developed by
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
in 2009 as an
analgesic medication.
AB-PINACA acts as a potent
agonist for the
CB1 receptor (''K''
i = 2.87 nM,
EC50 = 1.2 nM) and
CB2 receptor (''K''
i = 0.88 nM, EC
50 = 2.5 nM) and fully substitutes for
Δ9-THC in rat discrimination studies, while being 1.5x more potent.
There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.
Legal status
Germany
AB-PINACA is an
Anlage II
Anlage may refer to:
* Allele, a specific version of a gene, as used by Gregor Mendel
* Anlage Süd
''Anlage Süd'' (English: ''Installation South'') was a pair of railway headquarters built for Adolf Hitler in the Nazi-occupied part of southe ...
controlled substance in
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
as of November 2014.
Singapore
It is listed in the Fifth Schedule of the Misuse of Drugs Act and so is illegal in
Singapore
Singapore (), officially the Republic of Singapore, is a sovereign island country and city-state in maritime Southeast Asia. It lies about one degree of latitude () north of the equator, off the southern tip of the Malay Peninsula, bor ...
, as of May 2015.
United States
It is a
Schedule I controlled substance in the
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...
.
China
It is a controlled substance in
China as of October 2015.
France
It is a controlled substance in
France
France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of overseas regions and territories in the Americas and the Atlantic, Pacific and Indian Oceans. Its metropolitan area ...
as of March 2017.
See also
*
5F-AB-PINACA
*
5F-ADB
*
5F-AMB
*
5F-APINACA
*
5F-CUMYL-PINACA
5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in e-cigarette form as C-Liquid) is an indazole-3-carboxamide based synthetic cannabinoid. 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with the original patent c ...
*
AB-CHFUPYCA
*
AB-FUBINACA
AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. It was originally developed by P ...
*
AB-PICA
AB-PICA is a potent agonist for the CB1 receptor (EC50 = 12 nM) and CB2 receptor (EC50 = 12 nM).
See also
* 5F-AB-PINACA
* 5F-ADB
* 5F-AMB
* 5F-APINACA
* 5F-CUMYL-PINACA
* AB-CHFUPYCA
* AB-FUBINACA
* ADB-CHMINACA
* ADB-FUBINACA
* ADB-PINAC ...
*
ADB-CHMINACA
ADB-CHMINACA (also known as MAB-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of ''K''i = 0.289 nM and was originally developed by Pfizer in 2009 as an ana ...
*
ADB-FUBINACA
*
ADB-PINACA
ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the CB1 receptor and CB2 receptor with EC50 values of 0.52 nM and 0.88 nM respectively. Like MDMB-FUBINA ...
*
ADBICA
ADBICA (also known as ADB-PICA) is a designer drug identified in synthetic cannabis blends in Japan in 2013. ADBICA had not previously been reported in the scientific literature prior to its sale as a component of synthetic cannabis blends. ADBI ...
*
APICA APICA or Apica may refer to:
Toponyms
* Apica River, stream in Charlevoix Regional County Municipality, Capitale-Nationale, Quebec, Canada
* Mont-Apica, Quebec, unorganized territory in Lac-Saint-Jean-Est Regional County Municipality, Saguenayâ ...
*
APINACA
APINACA (AKB48, ''N''-(1-adamantyl)-1-pentyl-1''H''-indazole-3-carboxamide) is a drug that acts as a reasonably potent agonist for the cannabinoid receptors, with a Ki of 304.5nM and an EC50 of 585nM at CB1. It had never previously been report ...
*
MDMB-CHMICA
MDMB-CHMICA is an indole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer drug. While MDMB-CHMICA was initially sold under the name "MMB-CHMINACA", the compound corresponding to this ...
*
PX-3
PX-3 (also known as APP-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of ''K''i = 47.6 nM and was originally developed by Pfizer in 2009 as an analgesic m ...
References
{{Cannabinoids
Cannabinoids
Designer drugs
Indazolecarboxamides
CB1 receptor agonists
CB2 receptor agonists