A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D₄ subtype, with significantly improved selectivity over older D₄-preferring compounds such as

PD-168,077 PD-168,077 is a drug which acts as a dopamine agonist A dopamine agonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D2-like and D1-like, and they are all G protein-coupled receptors. D1- ...

and

CP-226,269 CP-226,269 is a drug which acts as a dopamine agonist selective for the D4 subtype, which is used for researching the role of D4 receptors in the brain. Synthesis The piperazine used has dual use in the synthesis of ABT-724, ABT-670, Azapero ...

. In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. Also unlike other dopamine agonists, selective D₄ agonists do not cause side effects such as

sedation Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, ...

and nausea, and so might have advantages over older dopamine agonist drugs.

References

Dopamine agonists Acetanilides Piperidines 2-Pyridyl compounds {{nervous-system-drug-stub