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The Info List - 8-Cyclopentyl-1,3-dimethylxanthine


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8-CYCLOPENTYL-1,3-DIMETHYLXANTHINE (8-CYCLOPENTYLTHEOPHYLLINE, 8-CPT, CPX) is a drug which acts as a potent and selective antagonist for the adenosine receptors , with some selectivity for the A1 receptor subtype, as well as a non-selective phosphodiesterase inhibitor . It has stimulant effects in animals with slightly higher potency than caffeine .

SEE ALSO

* 8-Chlorotheophylline * 8-Phenyltheophylline * DMPX * DPCPX * Xanthine

REFERENCES

* ^ Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology. 95 (1): 19–24. doi :10.1007/bf00212759 . PMID 3133696 . * ^ Karcz-Kubicha M; Antoniou K; Terasmaa A; Quarta D; Solinas M; Justinova Z; Pezzola A; Reggio R; Müller CE; Fuxe K; Goldberg SR; Popoli P; Ferré S (July 2003). "Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration". Neuropsychopharmacology. 28 (7): 1281–91. doi :10.1038/sj.npp.1300167 . PMID 12700682 .

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Purine receptor modulators

Receptor (ligands )

P0 (ADENINE )

* AGONISTS: 8-Aminoadenine * Adenine

P1 (adenosine )

* AGONISTS: 2-(1-Hexynyl)-N-methyladenosine * 2-Cl-IB-MECA * 2\'-MeCCPA * 4\'-O-β-D-Glucosyl-9-O-(6\'\'-deoxysaccharosyl)olivil * 5\'-N-ethylcarboxamidoadenosine * Adenosine * ADP * AMP * Apadenoson * ATL-146e * ATP * BAY 60–6583 * Binodenoson * Capadenoson * CCPA * CGS-21680 * CP-532,903 * Evodenoson * GR 79236 * LUF-5835 * LUF-5845 * N6-Cyclopentyladenosine * Namodenoson * Neladenoson dalanate * Piclidenoson * Regadenoson * SDZ WAG 994 * Selodenoson * Sonedenoson * Tecadenoson * UK-432,097

* ANTAGONISTS: 8-Chlorotheophylline * 8-Phenyl-1,3-dipropylxanthine * 8-Phenyltheophylline * Acefylline * Aminophylline * ATL-444 * Bamifylline * Cafedrine * Caffeine * Caffeine citrate * Cartazolate * CGH-2466 * CGS-15943 * Choline theophyllinate * CPX * CVT-6883 * Dimethazan * DMPX * DPCPX * Dyphylline * Enprofylline * Etazolate * Fenethylline * IBMX * Isovaleric acid * Istradefylline * KF-26777 * MRE3008F20 * MRS-1220 * MRS-1334 * MRS-1706 * MRS-1754 * MRS-3777 * Paraxanthine * Pentoxifylline * Preladenant * Propentofylline * Proxyphylline * PSB-10 * PSB-11 * PSB-36 * PSB-603 * PSB-788 * PSB-1115 * Reversine * Rolofylline * SCH-442,416 * SCH-58261 * Theacrine * Theobromine * Theodrenaline * Theophylline * Tozadenant * Tracazolate * VUF-5574 * ZM-241,385

P2 (nucleotide )

P2X (ATP )

* AGONISTS: 2-Me-SATP * α,β-Me-ATP * Adenosine * ADP * AMP * Ap4A * Ap5A * ATP * ATPγS * BzATP * Cibacron blue * CTP * D-β,γ-Me-ATP * GTP * HT-AMP * Ivermectin * L-β,γ-Me-ATP * MRS-2219 * PAPET-ATP * UTP * Zinc

* ANTAGONISTS: 5-BDBD * A-317491 * A-438079 * A-740003 * A-804598 * A-839977 * AF-353 * AZ-10606120 * AZ-11645373 * BBG * Calcium * Calmidazolium * Chelerythrine * Copper * Emodin ( Rheum officinale ) * Evans Blue * GW-791343 * HMA * Ip5I * iso PPADS * JNJ-47965567 * KN-04 * KN-62 * Magnesium * MRS-2159 * NF-023 * NF-110 * NF-157 * NF-279 * NF-449 * Opiranserin (VVZ-149) * Oxidized-ATP * Phenol Red * Phenolphthalein * PPADS * PPNDS * PSB-12062 * Puerarin ( Radix puerariae ) * Purotoxin 1 * RB-2 * Ro 0437626 * Ro 51 * RO-3 * Sodium ferulate ( Angelica sinensis , Ligusticum wallichii ) * Suramin * TC-P 262 * Tetramethylpyrazine (ligustrazine) ( Ligusticum wallichii ) * TNP-ATP * Zinc

P2Y

* AGONISTS: 2-Me-SADP * 2-Me-SATP * 2-Thio-UTP * 5-Br-UDP * 5-OMe-UDP * α,β-Me-ATP * Adenosine * ADP * ADPβS * Ap3A * AR-C 67085MX * ATP * ATPγS * CTP * dATP * Denufosol * Diquafosol * IDP * ITP * INS-365 * INS-37217 * MRS-2365 * MRS-2690 * MRS-2693 * MRS-2768 * MRS-2957 * MRS-4062 * NF-546 * PAPET-ATP * PSB-0474 * PSB-1114 * UDP * UDPβS * UDP-galactose * UDP-glucose * UDP-N-acetylglucosamine * Up3U * UTP * UTPγS

* ANTAGONISTS: 2-Me-SAMP * A3P5PS * AMPαS * Ap4A * AR-C 66096 * AR-C 67085MX * AR-C 69931MX * AR-C 118925XX * ATP * BzATP * C1330-7 * Cangrelor * Clopidogrel * Elinogrel * Ip5I * MRS-2179 * MRS-2211 * MRS-2279 * MRS-2395 * MRS-2500 * MRS-2578 * NF-157 * NF-340 * PIT * PPADS * Prasugrel * PSB-0739 * RB-2 * Regrelor * Suramin * Ticagrelor * Ticlopidine * UDP

Transporter (blockers )

CNTS

* 6-Hydroxy-7-methoxyflavone * Adenosine * dMeThPmR * Estradiol * KGO-2142 * KGO-2173 * MeThPmR * Phloridzin * Progesterone

ENTS

* Barbiturates * Benzodiazepines * Cilostazol * Dilazep * Dipyridamole * Estradiol * Ethanol * Hexobendine * NBMPR * Pentoxifylline * Progesterone * Propentofylline

PMAT

* Decynium-22

Enzyme (inhibitors )

XO

* Allopurinol * Amflutizole * Benzbromarone * Caffeic acid * Cinnamaldehyde * Cinnamomum osmophloeum * Febuxostat * Myo-inositol * Kaempferol * Myricetin * Niraxostat * Oxipurinol * Phytic acid * Pistacia integerrima * Propolis * Quercetin * Tisopurine * Topiroxostat

OTHERS

* Aminopterin * Azathioprine * Methotrexate * Mycophenolic acid * Pemetrexed * Pralatrexate * Many others

OTHERS

* PRECURSORS: Adenine * Adenosine * AMP * ADP * ATP * Cytosine * Cytidine * CMP * CDP * CTP * Guanine * Guanosine * GMP * GDP * GTP * Hypoxanthine * Inosine * IMP * IDP * ITP * Ribose * Uracil * Uridine * UMP * UDP * UTP

* OTHERS: Chrysophanol (rhubarb )

SEE ALSO: Receptor/signaling modulators

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Phosphodiesterase inhibitors

PDE1

* MMPX * SCH-51866 * Vinpocetine

PDE2

* BAY 60-7550 * Carbazeran * EHNA * Oxindole * PDP

PDE3

* Adibendan * Amrinone (inamrinone) * Anagrelide * Benafentrine * Bucladesine * Carbazeran * Cilostamide * Cilostazol * Enoximone * Imazodan * KMUP-1 * Meribendan * Milrinone * Olprinone * Parogrelil * Pimobendan * Pumafentrine * Quazinone * RPL-554 * Siguazodan * Trequinsin * Vesnarinone * Zardaverine

PDE4

* Apremilast * Arofylline * Atizoram * Benafentrine * Catramilast * CC-1088 * CDP-840 * CGH-2466 * Cilomilast * Cipamfylline * Crisaborole * Denbutylline * Drotaverine * Etazolate * Filaminast * Glaucine * HT-0712 * ICI-63197 * Indimilast * Irsogladine * Lavamilast * Lirimilast * Luteolin * Mesembrenone * Mesembrine * Mesopram * Oglemilast * Piclamilast * Pumafentrine * Revamilast * Ro 20-1724 * Roflumilast * Rolipram * Ronomilast * RPL-554 * RS-25344 * Tetomilast * Tofimilast * YM-976 * Zardaverine

PDE5

* Acetildenafil * Aildenafil * Avanafil * Beminafil * Benzamidenafil * Dasantafil * Icariin * Gisadenafil * Homosildenafil * Lodenafil * Mirodenafil * MY-5445 * Nitrosoprodenafil * Norcarbodenafil * SCH-51866 * Sildenafil * Sulfoaildenafil * T-0156 * Tadalafil * Udenafil * Vardenafil

PDE7

* BRL-50481

PDE9

* BAY 73-6691 * PF-04447943

PDE10

* Balipodect * Mardepodect * Papaverine * TC-E 5005 * Tofisopam

PDE11 BC11-38

NON-SELECTIVE

* Aminophylline * Caffeine * Choline theophyllinate * CPX * Dipyridamole * Doxofylline * Enprofylline * Ibudilast * IBMX * Luteolin * Paraxanthine * Pentoxifylline * Propentofylline * Theobromine * Theophylline * Zaprinast

UNSORTED

* Diazepam * Diprophylline * DPCPX * Furafylline * Lisofylline * MDL-12330A * Moxaverine * Oxagrelate * Pentifylline * Proxyphylline * Quercetin * Satigrel * Tolafentrine * Trapidil

SEE ALSO: Receptor/signaling modulators

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Stimulants

ADAMANTANES

* Adapromine * Amantadine * Bromantane * Memantine * Rimantadine

ADENOSINE ANTAGONISTS

* 8-Chlorotheophylline * 8-Cyclopentyltheophylline * 8-Phenyltheophylline * Aminophylline * Caffeine * CGS-15943 * Dimethazan * Paraxanthine * SCH-58261 * Theobromine * Theophylline

ALKYLAMINES

* Cyclopentamine * Cypenamine * Cyprodenate * Heptaminol * Isometheptene * Levopropylhexedrine * Methylhexaneamine * Octodrine * Propylhexedrine * Tuaminoheptane

AMPAKINES

* CX-516 * CX-546 * CX-614 * CX-691 * CX-717 * IDRA-21 * LY-404,187 * LY-503,430 * Nooglutyl * Org 26576 * PEPA * S-18986 * Sunifiram * Unifiram

ARYLCYCLOHEXYLAMINES

* Benocyclidine * Dieticyclidine * Esketamine * Eticyclidine * Gacyclidine * Ketamine * Phencyclamine * Phencyclidine * Rolicyclidine * Tenocyclidine * Tiletamine

BENZAZEPINES

* 6-Br-APB * SKF-77434 * SKF-81297 * SKF-82958

CHOLINERGICS

* A-84,543 * A-366,833 * ABT-202 * ABT-418 * AR-R17779 * Altinicline * Anabasine * Arecoline * Bradanicline * Cotinine * Cytisine * Dianicline * Epibatidine * Epiboxidine * GTS-21 * Ispronicline * Nicotine * PHA-543,613 * PNU-120,596 * PNU-282,987 * Pozanicline * Rivanicline * Sazetidine A * SIB-1553A * SSR-180,711 * TC-1698 * TC-1827 * TC-2216 * Tebanicline * UB-165 * Varenicline * WAY-317,538

CONVULSANTS

* Anatoxin-a * Bicuculline * DMCM * Flurothyl * Gabazine * Pentetrazol * Picrotoxin * Strychnine * Thujone

EUGEROICS

* Adrafinil * Armodafinil * CRL-40,940 * CRL-40,941 * Fluorenol * JZ-IV-10 * Modafinil

OXAZOLINES

* 4-Methylaminorex * Aminorex * Clominorex * Cyclazodone * Fenozolone * Fluminorex * Pemoline * Thozalinone

PHENETHYLAMINES

* 1-(4-Methylphenyl)-2-aminobutane * 1-Methylamino-1-(3,4-methylenedioxyphenyl)propane * 2-Fuoroamphetamine * 2-Fuoromethamphetamine * 2-OH-PEA * 2-Phenyl-3-aminobutane * 2,3-MDA * 3-Fuoroamphetamine * 3-Fluoroethamphetamine * 3-Fluoromethcathinone * 3-Methoxyamphetamine * 3-Methylamphetamine * 3,4-DMMC * 4-BMC * 4-CMC * 4-Ethylamphetamine * 4-Fluoroamphetamine * 4-Fluoromethamphetamine * 4-MA * 4-Methylbuphedrone * 4-Methylcathinone * 4-MMA * 4-Methylpentedrone * 4-MTA * 6-FNE * AL-1095 * Alfetamine * a-Ethylphenethylamine * Amfecloral * Amfepentorex * Amfepramone * Amidephrine * 2-Amino-1,2-dihydronaphthalene * 2-Aminoindane * 5-(2-Aminopropyl)indole * 2-Aminotetralin * Acridorex * Amphetamine ( Dextroamphetamine , Levoamphetamine ) * Amphetaminil * Arbutamine * β-Methylphenethylamine * β-Phenylmethamphetamine * Benfluorex * Benzedrone * Benzphetamine * BDB * BOH * 3-Benzhydrylmorpholine * BPAP * Buphedrone * Bupropion * Butylone * Camfetamine * Cathine * Cathinone * Chlorphentermine * Cilobamine * Cinnamedrine * Clenbuterol * Clobenzorex * Cloforex * Clortermine * Cypenamine * D-Deprenyl * Denopamine * Dimethoxyamphetamine * Dimethylamphetamine * Dimethylcathinone * Dobutamine * DOPA (Dextrodopa , Levodopa ) * Dopamine * Dopexamine * Droxidopa * EBDB * Ephedrine * Epinephrine * Epinine * Etafedrine * Ethcathinone * Ethylnorepinephrine * Ethylone * Etilamfetamine * Etilefrine * Famprofazone * Fencamfamin * Fencamine * Fenethylline * Fenfluramine ( Dexfenfluramine , Levofenfluramine ) * Fenproporex * Feprosidnine * Flephedrone * Fludorex * Formetorex * Furfenorex * Gepefrine * Hexapradol * Hexedrone * HMMA * Hordenine * 4-Hydroxyamphetamine * 5-Iodo-2-aminoindane * Ibopamine * IMP * Indanylamphetamine * Iofetamine * Isoetarine * Isoethcathinone * Isoprenaline * L-Deprenyl (Selegiline) * Lefetamine * Lisdexamfetamine * Lophophine * MBDB * MDA (tenamfetamine) * MDBU * MDEA * MDMA (midomafetamine) * MDMPEA * MDOH * MDPR * MDPEA * Mefenorex * Mephedrone * Mephentermine * Metanephrine * Metaraminol * Mesocarb * Methamphetamine (Dextromethamphetamine , Levomethamphetamine ) * Methoxamine * Methoxyphenamine * MMA * Methcathinone * Methedrone * Methoxyphenamine * Methylenedioxycathinone * Methylone * Mexedrone * MMDA * M MDMA * MMMA * Morforex * N,alpha-Diethylphenylethylamine * N-Ethylbuphedrone * N-Ethylhexedrone * N,N-Dimethylphenethylamine * Naphthylamphetamine * Nisoxetine * Norepinephrine * Norfenefrine * Norfenfluramine * Normetanephrine * L-Norpseudoephedrine * Octopamine (drug) * Orciprenaline * Ortetamine * Oxifentorex * Oxilofrine * PBA * PCA * PCMA * PHA * Pentorex * Pentedrone * Pentylone * Phenatine * Phenpromethamine * Phentermine * Phenylalanine * Phenylephrine * Phenylpropanolamine * Pholedrine * PIA * PMA * PMEA * PMMA * PPAP * Phthalimidopropiophenone * Prenylamine * Propylamphetamine * Pseudoephedrine * Ropinirole * Salbutamol ( Levosalbutamol ) * Sibutramine * Solriamfetol * Synephrine * Theodrenaline * Tiflorex * Tranylcypromine * Tyramine * Tyrosine * Xylopropamine * Zylofuramine

PHENYLMORPHOLINES

* 3-Fluorophenmetrazine * Fenbutrazate * Fenmetramide * G-130 * Manifaxine * Morazone * Morforex * Oxaflozane * PD-128,907 * Phendimetrazine * Phenmetrazine * 2-Phenyl-3,6-dimethylmorpholine * Pseudophenmetrazine * Radafaxine

PIPERAZINES

* 2C-B-BZP * 3C-PEP * BZP * CM156 * DBL-583 * GBR-12783 * GBR-12935 * GBR-13069 * GBR-13098 * GBR-13119 * MeOPP * MBZP * oMPP * Vanoxerine

PIPERIDINES

* 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine * 2-Benzylpiperidine * 2-Methyl-3-phenylpiperidine * 3,4-Dichloromethylphenidate * 4-Benzylpiperidine * 4-Fluoromethylphenidate * 4-Methylmethylphenidate * Desoxypipradrol * Difemetorex * Diphenylpyraline * Ethylnaphthidate * Ethylphenidate * Methylnaphthidate * Isopropylphenidate * Methylphenidate ( Dexmethylphenidate ) * Nocaine * Phacetoperane * Pipradrol * Propylphenidate * SCH-5472

PYRROLIDINES

* 2-Diphenylmethylpyrrolidine * 5-DBFPV * α-PPP * α-PBP * α-PHP * α-PVP * α-PVT * Diphenylprolinol * DMPVP * FPOP * FPVP * MDPPP * MDPBP * MPBP * MPHP * MPPP * MOPVP * MOPPP * Indapyrophenidone * MDPV * Naphyrone * PEP * Picilorex * Prolintane * Pyrovalerone

RACETAMS

* Oxiracetam * Phenylpiracetam * Phenylpiracetam hydrazide

TROPANES

* 4-fluorotropacocaine * 4\'-Fluorococaine * Altropane (IACFT) * Brasofensine * CFT (WIN 35,428) * β-CIT (RTI-55) * Cocaethylene * Cocaine * Dichloropane (RTI-111) * Difluoropine * FE-β-CPPIT * FP-β-CPPIT * Ioflupane (123I) * Norcocaine * PIT * PTT * RTI-31 * RTI-32 * RTI-51 * RTI-112 * RTI-113 * RTI-120 * RTI-121 (IPCIT) * RTI-126 * RTI-150 * RTI-177 * RTI-229 * RTI-336 * RTI-354 * RTI-371 * RTI-386 * Salicylmethylecgonine * Tesofensine * Troparil (β-CPT, WIN 35,065-2) * Tropoxane * WF-23 * WF-33

TRYPTAMINES

* 4-HO-αMT * 4-Methyl-αET * 4-Methyl-αMT * 5-Chloro-αMT * 5-Fluoro-αMT * 5-MeO-αET * 5-MeO-αMT * 5-MeO-DIPT * 6-Fluoro-αMT * 7-Methyl-αET * αET * αMT

OTHERS

* 2-MDP * 3,3-Diphenylcyclobutanamine * Amfonelic acid * Amineptine * Amiphenazole * Atipamezole * Atomoxetine * Bemegride * Benzydamine * BTQ * BTS 74,398 * Centanafadine * Ciclazindol * Clofenciclan * Cropropamide * Crotetamide * D-161 * Desipramine * Diclofensine * Dimethocaine * Efaroxan * Etamivan * Fenisorex * Fenpentadiol * Gamfexine * Gilutensin * GSK1360707F * GYKI-52895 * Hexacyclonate * Idazoxan * Indanorex * Indatraline * JNJ-7925476 * Lazabemide * Leptacline * Lomevactone * LR-5182 * Mazindol * Meclofenoxate * Medifoxamine * Mefexamide * Methamnetamine * Methastyridone * Methiopropamine * Naphthylaminopropane * Nefopam * Nikethamide * Nomifensine * O-2172 * Oxaprotiline * PNU-99,194 * PRC200-SS * Rasagiline * Rauwolscine * Rubidium chloride * Setazindol * Tametraline * Tandamine * Thiopropamine * Thiothinone * Trazium * UH-232 * Yohimbine

ATC code : N06B

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