5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in

e-cigarette An electronic cigarette is an electronic device that simulates tobacco smoking. It consists of an atomizer, a power source such as a battery, and a container such as a cartridge or tank. Instead of smoke, the user inhales vapor. As such ...

form as C-Liquid) is an

indazole Indazole, also called isoindazole, is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and pyrazole. Indazole is an amphoteric molecule which can be protonated to an indazolium cation or deproton ...

-3-carboxamide based

synthetic cannabinoid Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids ( THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthe ...

. 5F-CUMYL-PINACA acts as a potent

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

for the

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid recep ...

s, with the original patent claiming approximately 4x selectivity for CB₁, having an EC₅₀ of <0.1 nM for human CB₁ receptors and 0.37 nM for human CB₂ receptors. In more recent assays using different techniques, 5F-CUMYL-PINACA was variously found to have an EC₅₀ of 0.43 nM at CB₁ and 11.3 nM at CB₂, suggesting a somewhat higher CB₁ selectivity of 26 times, or alternatively 15.1 nM at CB₁ and 34.8 nM at CB₂ with only 2.3 times selectivity, however these figures cannot be directly compared due to the different assay techniques used in each case.

Legal status

In the United States, 5F-CUMYL-PINACA was temporarily emergency scheduled by the DEA in 2019. and made a permanent

Schedule I Controlled Substance This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pla ...

on April 7, 2022. Sweden's public health agency suggested classifying 5F-CUMYL-PINACA as a hazardous substance on November 10, 2014.

References

{{Cannabinoidergics Cannabinoids Designer drugs Indazolecarboxamides Organofluorides

Legal status

See also

References