5-(Nonyloxy)tryptamine is a

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

derivative In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...

which acts as a selective

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

at the 5-HT_1B receptor. Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT_1B, with highest activity found for the nonyloxy derivative, having a 5-HT_1B

binding affinity In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a mo ...

of 1.0 nM, and around 300-fold selectivity over the related 5-HT_1A receptor.

References

Serotonin receptor agonists Tryptamines Indole ethers at the benzene ring {{nervous-system-drug-stub

See also

References