4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme
fatty acid amide hydrolase (FAAH), with an IC
50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme
MAGL, which it inhibits with an IC
50 of 7900nM. It is also a weaker inhibitor of the enzymes
endothelial lipase
Endothelial lipase (LIPG) is a form of lipase secreted by vascular endothelial cells in tissues with high metabolic rates and vascularization, such as the liver, lung, kidney, and thyroid gland. The LIPG enzyme is a vital component to many biologi ...
and
lipoprotein lipase
Lipoprotein lipase (LPL) (EC 3.1.1.34, systematic name triacylglycerol acylhydrolase (lipoprotein-dependent)) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble ...
, with values of 100 nM and 1400 nM respectively.
See also
*
IDFP
IDFP is an organophosphorus compound related to the nerve agent sarin.
Like sarin, IDFP is an irreversible inhibitor for a number of different enzymes that normally serve to break down neurotransmitters, however the long alkyl chain of IDFP make ...
*
LY-2183240
*
URB-597
References
{{DEFAULTSORT:Nonylphenylboronic acid, 4-
Enzyme inhibitors
Boronic acids