4-Fluorobutyrylfentanyl (also known as 4-FBF and p-FBF or para-fluorobutyrylfentanyl) is an
opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use ...
analgesic that is an
analog
Analog or analogue may refer to:
Computing and electronics
* Analog signal, in which information is encoded in a continuous variable
** Analog device, an apparatus that operates on analog signals
*** Analog electronics, circuits which use analog ...
of
butyrfentanyl and has been sold online as a
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...
. It is closely related to
4-fluorofentanyl, which has an EC
50 value of 4.2 nM for the human
μ-opioid receptor
The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical Π...
.
Side effects
Side effects of
fentanyl
Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
analogs are similar to those of fentanyl itself, which include
itching
Itch (also known as pruritus) is a Wikt:sensation, sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of Sensory system, sensory experience. Itch has many similarities to pain, ...
,
nausea
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the ...
and potentially serious
respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.
Legal status
Sweden's public health agency suggested classifying 4-fluorobutyrylfentanyl as hazardous substance on August 18, 2014.
In October 2015, 4-fluorobutyrylfentanyl became a controlled substance in China.
4-Fluorobutyrfentanyl is a Schedule I controlled drug in the USA since 1. February 2018.
See also
*
3-Methylbutyrfentanyl
*
3-Methylfentanyl
*
4-Fluorofentanyl
*
4-Fluoroisobutyrfentanyl
*
α-Methylfentanyl
*
Acetylfentanyl
*
Acrylfentanyl
*
Furanylfentanyl
*
List of fentanyl analogues
References
{{DEFAULTSORT:Fluorobutyrfentanyl, 4-
Synthetic opioids
Designer drugs
Anilides
Piperidines
Propionamides
Mu-opioid receptor agonists
Fluoroarenes