3C-DFE is a lesser-known
psychedelic drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science o ...
, which is a fluorinated derivative of
3C-E
3C-E is a psychedelic of the amphetamine class. It was first synthesized by Alexander Shulgin. In his book '' PiHKAL'', Shulgin lists the dosage range as 30 to 60 mg, consumed orally. The duration of action was stated to be 8–12 hours.
T ...
. It was first synthesised by Daniel Trachsel in 2002,
and has been reported as showing similar psychedelic activity to related compounds, with a dose range of around 20–40 mg and a duration of approximately 10 hours.
Despite its reported psychedelic activity, binding studies ''in vitro'' showed 3C-DFE to have a surprisingly weak
binding affinity
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose. The etymology stems from ''ligare'', which means 'to bind'. In protein-ligand binding, the ligand is usually a mo ...
of 2695 nM at
5-HT2A with negligible affinity at
5-HT2C,
[ making it only slightly higher affinity than ]mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin.
Biological ...
, despite its higher potency ''in vivo''.
See also
* 2C-TFE
* Escaline
Escaline (3,5-methoxy-4-ethoxyphenethylamine) is a psychedelic drug and entheogen of the phenethylamine class of compounds. Escaline was first synthesized and reported in the scientific literature by Benington, et al., in 1954, but was later re-ex ...
* DOTFM
* 2C-T-21
* 2C-T-28
2C-T-28 is a lesser-known psychedelic drug related to compounds such as 2C-T-7 and 2C-T-21. It was named by Alexander Shulgin but was never made or tested by him, and was instead first synthesised by Daniel Trachsel some years later. It has a bin ...
* 3C-P
3C-P (α-Methyl-4-propoxy-3,5-dimethoxyphenethylamine) is a psychedelic phenethylamine. It has structural and pharmacodynamic properties similar to the drugs mescaline, proscaline, and amphetamine. Little information exists on the human pharmac ...
* Trifluoromescaline
References
Mescalines
Entheogens
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