The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the reaction
:3-hydroxy-2-methylpropanoyl-CoA + H
2O
CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of
hydrolases, specifically those acting on
thioester
In organic chemistry, thioesters are organosulfur compounds with the functional group . They are analogous to carboxylate esters () with the sulfur in the thioester playing the role of the linking oxygen in the carboxylate ester, as implied by t ...
bonds. The
systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3
metabolic pathways:
valine, leucine and isoleucine degradation,
β-alanine metabolism, and
propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by ''HIBCH'' gene.
References
*
EC 3.1.2
Enzymes of unknown structure
{{3.1-enzyme-stub