3-hydroxyisobutyryl-CoA hydrolase
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The enzyme 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4)
catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the reaction :3-hydroxy-2-methylpropanoyl-CoA + H2O \rightleftharpoons CoA + 3-hydroxy-2-methylpropanoate This enzyme belongs to the family of hydrolases, specifically those acting on
thioester In organic chemistry, thioesters are organosulfur compounds with the functional group . They are analogous to carboxylate esters () with the sulfur in the thioester playing the role of the linking oxygen in the carboxylate ester, as implied by t ...
bonds. The systematic name is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, β-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by ''HIBCH'' gene.


References

* EC 3.1.2 Enzymes of unknown structure {{3.1-enzyme-stub