In
enzymology
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
, a 3-hydroxy-2-methylbutyryl-CoA dehydrogenase () is an
enzyme that
catalyzes
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...
the
chemical reaction
:(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD
+ 2-methylacetoacetyl-CoA + NADH + H
+
Thus, the two
substrates of this enzyme are
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA and
NAD+, whereas its 3
products are
2-methylacetoacetyl-CoA,
NADH, and
H+.
This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-OH group of donor with NAD
+ or NADP
+ as acceptor. The
systematic name of this enzyme class is (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD
+ oxidoreductase. Other names in common use include 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, 2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase, and 2-methyl-3-hydroxy-butyryl CoA dehydrogenase. This enzyme participates in
valine, leucine and isoleucine degradation.
Structural studies
As of 20 January 2010, 6
structure
A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...
have been solved for this class of enzymes, with the
PDB accession code , , , , , .
References
*
EC 1.1.1
NADH-dependent enzymes
Enzymes of known structure
{{1.1.1-enzyme-stub