3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol is a
synthetic Synthetic things are composed of multiple parts, often with the implication that they are artificial. In particular, 'synthetic' may refer to:
Science
* Synthetic chemical or compound, produced by the process of chemical synthesis
* Synthetic o ...
,
steroid
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and a ...
al
estrogen and a
selective agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
of the
ERβ.
It was discovered serendipitously and was the
lead compound among a series of
androsta-3,5-dienes as ERβ
ligands.
Its
affinity
Affinity may refer to:
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* Affinity Credit Union, a Saskatchewan-based credit union
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(
IC50) for the ERβ was found to be 9 nM and it showed 62- and 160-fold binding selectivity for this receptor over the and the
ERα, respectively.
The
EC50 of the compound for the ERβ was found to be 69 nM and its
intrinsic activity was 92% (relative to that of
estradiol).
As such, it is a
potent ERβ agonist with high affinity and selectivity.
References
Secondary alcohols
Androstanes
Selective ERβ agonists
Synthetic estrogens
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