2-''C''-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (MEcPP synthase, IspF, EC 4.6.1.12) is a

zinc Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodi ...

-dependent

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

and a member of the YgbB N terminal protein domain, which participates in the MEP pathway (non-mevalonate pathway) of isoprenoid precursor biosynthesis. It catalyzes the following reaction: :4-diphosphocytidyl-2-''C''-methyl-D)erythritol 2-phosphate

\rightleftharpoons

2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate + CMP The enzyme is considered a phosphorus-oxygen lyase. The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is 2-phospho-4-(cytidine 5′-diphospho)-2-''C''-methyl-D-D-erythritol CMP-lyase (cyclizing; 2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include IspF, YgbB and MEcPP synthase.

Structural studies

As of late 2007, 20

structures A structure is an arrangement and organization of interrelated elements in a material object or system, or the object or system so organized. Material structures include man-made objects such as buildings and machines and natural objects such as ...

have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , and .

References

EC 4.6.1 Enzymes of known structure {{lyase-stub