2β-Propanoyl-3β-(4-tolyl)tropane also known as WF-11 or 2-PTT is a
cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform
downregulation of
tyrosine hydroxylase protein and activity
gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. The ...
with a regimen of use.
See also
*
List of cocaine analogues
*
RTI-32
(–)-2β-Carbomethoxy-3β-(4- tolyl)tropane (RTI-''4229''-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties ''in vitro'' to related drugs such as RTI-31.
See also
* 2β-Propanoyl-3β-(4-tolyl)-tropane
* R ...
References
Tropanes
Stimulants
Norepinephrine–dopamine reuptake inhibitors
Ketones
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