β-Zearalenol is a
nonsteroidal estrogen of the
resorcylic acid lactone group related to
mycoestrogens found in ''
Fusarium spp''.
It is the β
epimer of
α-zearalenol and along with α-zearalenol is a major
metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism.
The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, c ...
of
zearalenone formed mainly in the
liver but also to a lesser extent in the
intestine
The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans ...
s during
first-pass metabolism.
A relatively high proportion of α-zearalenol is formed from zearalenone compared to β-zearalenol in humans.
β-Zearalenol is about the same or slightly less potent as an estrogen relative to zearalenone.
See also
*
Taleranol
Taleranol (International Nonproprietary Name, INN, United States Adopted Name, USAN) (developmental code name P-1560), or teranol, also known as β-zearalanol, is a synthetic compound, synthetic, nonsteroidal estrogen of the resorcylic acid lacto ...
(β-zearalanol)
*
Zeranol (α-zearalanol)
*
Zearalanone
References
{{DEFAULTSORT:Zearalenol, alpha-
Lactones
Mycoestrogens
Mycotoxins
Resorcinols