enzymology Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

, a 3-oxoacyl- cyl-carrier-proteinreductase () is an enzyme that

catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

the chemical reaction :3-oxoacyl- cyl-carrier-protein ACP) +

NADPH Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NAD ...

+ H⁺

\rightleftharpoons

(3''R'')-3-hydroxyacyl- cyl-carrier-protein ACP) + NADP⁺ : This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group as hydride donor with NAD⁺ or NADP⁺ as hydride acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl- cyl-carrier-proteinNADP⁺ oxidoreductase. Other names in common use include beta-ketoacyl- cyl-carrier proteinACP) reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, 3-ketoacyl acyl carrier protein reductase, 3-ketoacyl ACP reductase, NADPH-specific 3-oxoacyl- cylcarrier proteineductase, and 3-oxoacyl- CPeductase. This enzyme participates in

fatty acid biosynthesis Fatty is a derogatory term for someone who is obese. It may refer also to: People * Mai Fatty, Gambian politician * Roscoe Arbuckle (1887–1933), American actor and comedian * Fatty Briody (1858–1903), American Major League Baseball player * ...

and polyunsaturated fatty acid biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , and .

References

* * * EC 1.1.1 NADPH-dependent enzymes Enzymes of known structure {{1.1.1-enzyme-stub