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ViiV Healthcare
ViiV Healthcare ( ) is a pharmaceutical company specializing in the development of therapies for HIV infection that was created as a joint venture by Pfizer and GlaxoSmithKline in November 2009 with both companies transferring their HIV assets to the new company.Jacks, Andre"GSK and Pfizer to Merge HIV PortfoliosFinancial Times. 16 April 2010 In 2012 Shionogi joined the company. 76.5% of the company is now owned by GlaxoSmithKline, 13.5% by Pfizer and 10% by Shionogi. This ownership structure may change depending upon the achievement of certain milestones. ViiV Healthcare's products have a market share of approximately 19% of the global HIV market, making it the second-largest healthcare company, after Gilead Sciences, which is working on the treatment of HIV. ViiV Healthcare's headquarters are in Brentford in the United Kingdom and it has sites in a number of other countries including; the United States, Australia, Belgium, Canada, France, Germany, Italy, Japan, Mexico, the N ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brentford
Brentford is a suburban town in West London, England and part of the London Borough of Hounslow. It lies at the confluence of the River Brent and the Thames, west of Charing Cross. Its economy has diverse company headquarters buildings which mark the start of the M4 corridor; in transport it also has two railway stations and Boston Manor Underground station on its north-west border with Hanwell. Brentford has a convenience shopping and dining venue grid of streets at its centre. Brentford at the start of the 21st century attracted regeneration of its little-used warehouse premises and docks including the re-modelling of the waterfront to provide more economically active shops, townhouses and apartments, some of which comprises Brentford Dock. A 19th and 20th centuries mixed social and private housing locality: New Brentford is contiguous with the Osterley neighbourhood of Isleworth and Syon Park and the Great West Road which has most of the largest business premises. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cabotegravir
Cabotegravir, sold under the brand name Vocabria among others, is a antiretroviral medication used for the treatment of HIV/AIDS. It is available in the form of tablets and as an intramuscular injection, as well as in an injectable combination with rilpivirine under the brand name Cabenuva. It is an integrase inhibitor with a carbamoyl pyridone structure similar to that of dolutegravir. In December 2021, the U.S. Food and Drug Administration approved cabotegravir for pre-exposure prophylaxis (PrEP) in at-risk people under the brand name Apretude. Medical uses Cabotegravir in combination with rilpivirine is indicated for the treatment of human immunodeficiency virus type-1 (HIV-1) in adults. The combination injection is intended for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/mL) with their current antiretroviral treatment, and when the virus has not developed resistance to non-nucleoside reverse transcriptas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Janssen Pharmaceutica
Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based American corporation Johnson & Johnson, and became part of Johnson & Johnson Pharmaceutical Research and Development (J&J PRD), now renamed to Janssen Research and Development (JRD), which conducts research and development activities related to a wide range of human medical disorders, including mental illness, neurological disorders, anesthesia and analgesia, gastrointestinal disorders, fungal infection, HIV/AIDS, allergies and cancer. Janssen and Ortho-McNeil Pharmaceutical have been placed in the Ortho-McNeil-Janssen group within Johnson & Johnson Company. Subsidiaries * Actelion * Cilag AG * Janssen Biotech (formerly ''Centocor'') * Janssen Vaccines (formerly ''Crucell'') * Tibotec * Beijing Dabao Cosmetics Co., Ltd. History The early ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolutegravir/rilpivirine
Dolutegravir/rilpivirine, sold under the brand name Juluca, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It contains the medicines dolutegravir and rilpivirine. It is taken by mouth. The most common adverse reactions (of all severity grades) are diarrhea and headache. Dolutegravir/rilpivirine was approved for use in the United States in November 2017, and for use in the European Union in May 2018. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. __TOC__ Medical uses Dolutegravir/rilpivirine is indicated In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery. There can be multiple indications to use a procedure or medication. An indication can commonly be confused with the term diagnosis. A diagnosis ... for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolutegravir/lamivudine
Dolutegravir/lamivudine, sold under the brand name Dovato, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It contains dolutegravir, as the salt, an integrase strand transfer inhibitor (INSTI), and lamivudine, a nucleoside analogue reverse transcriptase inhibitor (NRTI). It is taken by mouth. It was approved for use in the United States in April 2019, and in the European Union in July 2019, Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged. and again with revisions in June 2022. The most common side effects are headache, diarrhea, nausea, and difficulty sleeping. The most common serious side effects are allergic reactions, including rash and severe liver problems. Dolutegravir/lamivudine is the first FDA-approved two-drug, fixed-dose, complete regimen for HIV-infected adults who have never received treatment for HIV. Medical uses In the EU, dolut ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abacavir/dolutegravir/lamivudine
Abacavir/dolutegravir/lamivudine, sold under the brand name Triumeq among others, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It is a combination of three medications with different and complementary mechanisms of action: abacavir (reverse transcriptase inhibitor), dolutegravir (integrase inhibitor) and lamivudine ( nucleoside analog reverse transcriptase inhibitor). The medication was developed by ViiV Healthcare and was approved for use in the United States and in the European Union in 2014. Abacavir is a nucleotide reverse transcriptase inhibitor. Specifically, abacavir is a guanosine analogue that interferes with HIV viral RNA-dependent DNA polymerase, ultimately resulting in inhibition of replication of HIV. Dolutegravir inhibits the HIV replication cycle by binding to the integrase active site and inhibiting the strand transfer step of HIV-1 DNA integration. Lamivudine is a cytosine analogue that inhibits HIV reverse transcriptio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lamivudine/zidovudine
Lamivudine/zidovudine, sold under the brand name Combivir among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains two antiretroviral medications, lamivudine and zidovudine. It is used together with other antiretrovirals. It is taken by mouth twice a day. Common side effects include headache, feeling tired, nausea, diarrhea, and fever. Severe side effects may include bone marrow suppression, muscle damage, worsening of hepatitis B if previously infected, Lactic acidosis, high blood lactate and liver enlargement. It may be part of a recommended treatment during pregnancy. The medications are both of the nucleoside reverse transcriptase inhibitor (NRTI) class. They work by blocking the action of the enzyme, reverse transcriptase, that the virus requires to reproduce. Lamivudine/zidovudine was approved for medical use in the United States in 1997, and in the European Union in 1998. It is on the WHO Model List of Essential Medicines, W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abacavir/lamivudine/zidovudine
Abacavir/lamivudine/zidovudine, sold under the brand name Trizivir, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare: * abacavir sulfate ''(ABC)'' * lamivudine ''(3TC)'' * zidovudine ''(AZT'' or ''ZDV)'' It is indicated in the treatment of AIDS/HIV-1. For this purpose, the combination is very useful in pregnant women to decrease the risk of mother-to-child transmission. The most common effects include headache and nausea (feeling sick). Abacavir/lamivudine/zidovudine was approved for use in the United States and the European Union in 2000. In December 2013, Lupin Limited launched a generic version of abacavir/lamivudine/zidovudine. Side effects The most common side effects of abacavir/lamivudine/zidovudine include nausea, vomiting, diarrhea, fatigue, paresthesia and headache. As with many medication ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abacavir/lamivudine
Abacavir/lamivudine, sold under the brand name Kivexa among others, is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS. It contains abacavir and lamivudine. It is generally recommended for use with other antiretrovirals. It is commonly used as part of the preferred treatment in children. It is taken by mouth as a tablet. Common side effects include trouble sleeping, headache, depression, feeling tired, nausea, rash, and fever. Serious side effects may include high blood lactate levels, allergic reactions, and enlargement of the liver. It is not recommended in people with a specific gene known as HLA-B*5701. Safety in pregnancy has not been well studied but it appears to be okay. Lamivudine and abacavir are both nucleoside reverse transcriptase inhibitors (NRTI). Abacavir/lamivudine was approved for medical use in the United States in 2004. It is on the World Health Organization's List of Essential Medicines. Society and culture Names It is ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fixed-dose Combination (antiretroviral)
Antiretroviral drugs are used to manage HIV/AIDS. Multiple antiretroviral drugs are often combined into a single pill in order to reduce pill burden Polypharmacy (polypragmasia) is the simultaneous use of multiple medicines by a patient for their conditions. Most commonly it is defined as regularly taking five or more medicines but definitions vary in where they draw the line for the minimum .... Some of these combinations are complete single-tablet regimens; the others must be combined with additional pills to make a treatment regimen. References External links * {{DEFAULTSORT:Fixed-Dose Combination (Antiretroviral) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maraviroc
Maraviroc, sold under the brand names Selzentry (US) and Celsentri (EU), is an antiretroviral medication used to treat HIV infection. It is taken by mouth. It is in the CCR5 receptor antagonist class. It was approved for medical use in the United States in August 2007, and in the European Union in September 2007. Medical uses Maraviroc is indicated, in combination with other antiretroviral medications, for the treatment of only CCR5-tropic HIV-1 infection. Side effects Maraviroc can cause serious, life-threatening side effects. These include liver problems, skin reactions, and allergic reactions. An allergic reaction may happen before liver problems occur. Official labeling of Selzentry has black box warning for hepatotoxicity. The MOTIVATE trials showed no clinically relevant differences in safety between the maraviroc and placebo groups. Mechanism of action Maraviroc is an entry inhibitor. Specifically, maraviroc is a negative allosteric modulator of the CCR5 receptor, wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Entry Inhibitor
Entry inhibitors, also known as fusion inhibitors, are a class of antiviral drugs that prevent a virus from entering a cell, for example, by blocking a receptor. Entry inhibitors are used to treat conditions such as HIV and hepatitis D. HIV entry They are used in combination therapy for the treatment of HIV infection. This class of drugs interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS. Proteins There are several key proteins involved in the HIV entry process. * CD4, a protein receptor found on the surface of helper T cells in the human immune system, also called CD4+ T cells * gp120, a protein on HIV surface that binds to the CD4 receptor * CCR5, a second receptor found on the surface of CD4+ cells and macrophages, called a chemokine co-receptor * CXCR4, another chemokine co-receptor found on CD4+ cells * gp41, a HIV protein, close ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
