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Titin
4UOW, 1BPV, 1G1C, 1NCT, 1NCU, 1TIT, 1TIU, 1TKI, 1TNM, 1TNN, 1WAA, 1YA5, 2A38, 2BK8, 2F8V, 2ILL, 2J8H, 2J8O, 2NZI, 2RQ8, 2WP3, 2WWK, 2WWM, 2Y9R, 3KNB, 3LCY, 3LPW, 3PUC, 3Q5O, 3QP3, 4C4K, 4JNW, 4O00, 4QEG, 5BS0 IDENTIFIERS ALIASES TTN, CMD1G, CMH9, CMPD4, EOMFC, HMERF, LGMD2J, MYLK5, TMD, titin, SALMY EXTERNAL IDS MGI: 98864 HomoloGene: 130650 GeneCards: TTN GENE ONTOLOGY MOLECULAR FUNCTION • transferase activity • nucleotide binding • calcium ion binding • protein kinase activity • actinin binding • muscle alpha-actinin binding • structural molecule activity conferring elasticity • metal ion binding • telethonin binding • protease binding • protein self-association • actin filament binding • protein serine/threonine kinase activity • kinase activity • protein binding • identical protein binding • enzyme binding • protein tyrosine kinase activity • structural constituent of muscle •
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Titan (other)
TITAN may refer to: * Titan (mythology)
Titan (mythology)
, a race of deities * Titan (moon)
Titan (moon)
, a moon of SaturnCONTENTS* 1 Arts and entertainment * 1.1 Books * 1.2 Comics * 1.3 Film and television * 1.4 Gaming * 1.5 Music *
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Tintin (other)
TINTIN or TIN TIN may refer to: TINTIN COMICS SERIES* The Adventures of Tintin , a comics series by Belgian cartoonist Hergé * Tintin (character)
Tintin (character)
, a fictional character in the series * Category: Tintin books * Category:
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Titian
TIZIANO VECELLI or TIZIANO VECELLIO (pronounced ; c. 1488/1490 – 27 August 1576), known in English as TITIAN /ˈtɪʃən/ , was an Italian painter , the most important member of the 16th-century Venetian school . He was born in Pieve di Cadore , near Belluno (in Veneto
Veneto
, Republic of Venice ). During his lifetime he was often called _da Cadore_, taken from the place of his birth. Recognized by his contemporaries as "The Sun Amidst Small Stars" (recalling the famous final line of Dante\'s _Paradiso _), Titian
Titian
was one of the most versatile of Italian painters, equally adept with portraits, landscape backgrounds, and mythological and religious subjects
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Protein Data Bank
The PROTEIN DATA BANK (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids . The data, typically obtained by X-ray crystallography , NMR spectroscopy , or, increasingly, cryo-electron microscopy , and submitted by biologists and biochemists from around the world, are freely accessible on the Internet via the websites of its member organisations (PDBe, PDBj, and RCSB ). The PDB is overseen by an organization called the Worldwide Protein Data Bank , wwPDB. The PDB is a key resource in areas of structural biology , such as structural genomics . Most major scientific journals, and some funding agencies, now require scientists to submit their structure data to the PDB
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Mouse Genome Informatics
MOUSE GENOME INFORMATICS (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory , with funding by The National Human Genome Research Institute (NHGRI) , the National Cancer Institute (NCI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) . MGI provides access to data on the genetics, genomics and biology of the laboratory mouse to facilitate the study of human health and disease. The database integrates multiple projects with the two largest contributions from the Mouse Genome Database and Gene Expression Database (GXD) . The Mouse Genome Informatics resource is a collection of data, tools, and analyses created and tailored for use in the laboratory mouse , a widely used model organism
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HomoloGene
HOMOLOGENE, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes. The HomoloGene processing consists of the protein analysis from the input organisms. Sequences are compared using blastp, then matched up and put into groups, using a taxonomic tree built from sequence similarity, where closer related organisms are matched up first, and then further organisms are added to the tree. The protein alignments are mapped back to their corresponding DNA sequences, and then distance metrics as molecular distances Jukes and Cantor (1969) , Ka/Ks ratio can be calculated. The sequences are matched up by using a heuristic algorithm for maximizing the score globally, rather than locally, in a bipartite matching (see complete bipartite graph )
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Genecards
GENECARDS is a database of human genes that provides genomic , proteomic , transcriptomic , genetic and functional information on all known and predicted human genes. It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science . This database aims at providing a quick overview of the current available biomedical information about the searched gene, including the human genes, the encoded proteins , and the relevant diseases. The GeneCards
GeneCards
database provides access to free Web resources about more than 7000 all known human genes that integrated from >90 data resources, such as HGNC , Ensembl , and NCBI . The core gene list is based on approved gene symbols published by the HUGO Gene Nomenclature Committee (HGNC). The information are carefully gathered and selected from these databases by the powerful and user-friendly engine
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Gene Ontology
GENE ONTOLOGY (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species . More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis. GO is part of a larger classification effort, the Open Biomedical Ontologies (OBO)
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Gene Expression
GENE EXPRESSION is the process by which information from a gene is used in the synthesis of a functional gene product . These products are often proteins , but in non-protein coding genes such as transfer RNA
RNA
(tRNA) or small nuclear RNA
RNA
(snRNA) genes, the product is a functional RNA
RNA
. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms ), prokaryotes (bacteria and archaea ), and utilized by viruses —to generate the macromolecular machinery for life. Several steps in the gene expression process may be modulated, including the transcription , RNA
RNA
splicing , translation , and post-translational modification of a protein. Gene
Gene
regulation gives the cell control over structure and function, and is the basis for cellular differentiation , morphogenesis and the versatility and adaptability of any organism
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Entrez
The ENTREZ Global Query Cross-Database Search System is a federated search engine, or web portal that allows users to search many discrete health sciences databases at the National Center for Biotechnology Information (NCBI) website. The NCBI is a part of the National Library of Medicine (NLM), which is itself a department of the National Institutes of Health (NIH), which in turn is a part of the United States Department of Health and Human Services . The name "Entrez" (a greeting meaning "Come in!" in French) was chosen to reflect the spirit of welcoming the public to search the content available from the NLM. Entrez Global Query is an integrated search and retrieval system that provides access to all databases simultaneously with a single query string and user interface. Entrez can efficiently retrieve related sequences , structures , and references
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Ensembl
ENSEMBL GENOME DATABASE PROJECT is a joint scientific project between the European Bioinformatics Institute
European Bioinformatics Institute
and the Wellcome Trust Sanger Institute , which was launched in 1999 in response to the imminent completion of the Human Genome Project . After 10 years in existence, Ensembl's aim remains to provide a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other vertebrates and model organisms . Ensembl
Ensembl
is one of several well known genome browsers for the retrieval of genomic information. Similar databases and browsers are found at NCBI and the University of California, Santa Cruz (UCSC)
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Uniprot
UNIPROT is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects . It contains a large amount of information about the biological function of proteins derived from the research literature. CONTENTS * 1 The UniProt
UniProt
consortium * 2 The roots of UniProt
UniProt
databases * 3 Organization of UniProt
UniProt
databases * 3.1 UniProtKB * 3.1.1 UniProtKB/ Swiss-Prot * 3.1.2 UniProtKB/Tr EMBL
EMBL
* 3.2 UniParc * 3.2.1 Source databases * 3.3 UniRef * 4 Funding for UniProt
UniProt
* 5 References * 6 External links THE UNIPROT CONSORTIUMThe UniProt
UniProt
consortium comprises the European Bioinformatics Institute (EBI), the Swiss Institute of Bioinformatics (SIB), and the Protein
Protein
Information Resource (PIR)
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PubMed
PUBMED is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintains the database as part of the Entrez system of information retrieval . From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries . PubMed, first released in January 1996, ushered in the era of private, free, hom