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Replicon (genetics)
A replicon is a DNA
DNA
molecule or RNA
RNA
molecule, or a region of DNA
DNA
or RNA, that replicates from a single origin of replication.Contents1 Prokaryotes 2 Eukaryotes 3 See also 4 ReferencesProkaryotes[edit] For most prokaryotic chromosomes, the replicon is the entire chromosome. One notable exception found comes from archaea, where two Sulfolobus
Sulfolobus
species have been shown to contain three replicons. Examples of bacterial species that have been found to possess multiple replicons include: Rhodobacter sphaeroides (2), Vibrio cholerae,[1] and Burkholderia multivorans (3). These "secondary" (or tertiary) chromosomes are often described as a molecule that is a mixture between a true chromosome and a plasmid and are sometimes called "chromids"
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DNA
Deoxyribonucleic acid (/diˈɒksiˌraɪboʊnjʊˈkliːɪk, -ˈkleɪ.ɪk/ ( listen);[1] DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA
DNA
and ribonucleic acid (RNA) are nucleic acids; alongside proteins, lipids and complex carbohydrates (polysaccharides), they are one of the four major types of macromolecules that are essential for all known forms of life. Most DNA
DNA
molecules consist of two biopolymer strands coiled around each other to form a double helix. The two DNA
DNA
strands are called polynucleotides since they are composed of simpler monomer units called nucleotides.[2][3] Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a sugar called deoxyribose, and a phosphate group
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ORC2
5C8HIdentifiersAliases ORC2, ORC2L, origin recognition complex subunit 2External IDs MGI: 1328306 HomoloGene: 4512 GeneCards: ORC2 Gene
Gene
location (Human)Chr. Chromosome
Chromosome
2 (human)[1]Band 2q33.1 Start 200,908
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ORC4
NM_181742NM_001177313 NM_011958 NM_001355296RefSeq (protein)NP_001177808 NP_001177810 NP_001177811 NP_002543 NP_859525NP_859526NP_001170784 NP_036088 NP_001342225Location (UCSC) Chr 2: 147.93 – 148.02 Mb Chr 2: 48.9 – 48.95 Mb PubMed
PubMed
search [3] [4]WikidataView/Edit Human View/Edit Mouse Origin recognition complex
Origin recognition complex
subunit 4 is a protein that in humans is encoded by the ORC4
ORC4
(ORC4L) gene.[5][6][7]Contents1 Function 2 Interactions 3 References 4 Further readingFunction[edit] The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6
Cdc6
and Mcm proteins
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ORC5
NM_001197292 NM_002553 NM_181747NM_011959RefSeq (protein)NP_002544 NP_859531NP_036089Location (UCSC) Chr 7: 104.13 – 104.21 Mb Chr 5: 22.49 – 22.55 Mb PubMed
PubMed
search [3] [4]WikidataView/Edit Human View/Edit Mouse Origin recognition complex
Origin recognition complex
subunit 5 is a protein that in humans is encoded by the ORC5
ORC5
(ORC5L) gene.[5][6][7]Contents1 Function 2 Interactions 3 References 4 Further readingFunction[edit] The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6
Cdc6
and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex
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ORC6
3M03IdentifiersAliases ORC6, ORC6L, origin recognition complex subunit 6External IDs MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6 Gene
Gene
location (Human)Chr. Chromosome
Chromosome
16 (human)[1]Band 16q11.2 Start 46,689,643 bp[1]End 46,698,394 bp[1] <
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MCM2
4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4IdentifiersAliases MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70External IDs OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCards: MCM2 Gene
Gene
location (Human)Chr. Chromosome
Chromosome

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RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes. RNA
RNA
and DNA
DNA
are nucleic acids, and, along with lipids, proteins and carbohydrates, constitute the four major macromolecules essential for all known forms of life. Like DNA, RNA
RNA
is assembled as a chain of nucleotides, but unlike DNA
DNA
it is more often found in nature as a single-strand folded onto itself, rather than a paired double-strand. Cellular organisms use messenger RNA
RNA
(mRNA) to convey genetic information (using the nitrogenous bases guanine, uracil, adenine, and cytosine, denoted by the letters G, U, A, and C) that directs synthesis of specific proteins
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MCM3
NM_002388 NM_001270472NM_008563RefSeq (protein)NP_001257401 NP_002379NP_032589Location (UCSC) Chr 6: 52.26 – 52.28 Mb Chr 1: 20.8 – 20.82 Mb PubMed
PubMed
search [3] [4]WikidataView/Edit Human View/Edit MouseDNA replication licensing factor MCM3
MCM3
is a protein that in humans is encoded by the MCM3
MCM3
gene.[5]Contents1 Function 2 Interactions 3 See also 4 References 5 Further readingFunction[edit] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7
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MCM4
NM_005914 NM_182746NM_008565RefSeq (protein)NP_005905 NP_877423NP_032591Location (UCSC) Chr 8: 47.96 – 47.98 Mb Chr 16: 15.62 – 15.64 Mb PubMed
PubMed
search [3] [4]WikidataView/Edit Human View/Edit MouseDNA replication licensing factor MCM4
MCM4
is a protein that in humans is encoded by the MCM4
MCM4
gene.[5]Contents1 Function 2 See also 3 Interactions 4 References 5 Further readingFunction[edit] The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins
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MCM5
NM_006739NM_008566 NM_001302540RefSeq (protein)NP_006730n/aLocation (UCSC) Chr 22: 35.4 – 35.43 Mb Chr 8: 75.11 – 75.13 Mb PubMed
PubMed
search [3] [4]WikidataView/Edit Human View/Edit MouseDNA replication licensing factor MCM5
MCM5
is a protein that in humans is encoded by the MCM5
MCM5
gene.[5][6][7]Contents1 Function 2 See also 3 Interactions 4 References 5 Further readingFunction[edit] The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family
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Special
Special
Special
or specials may refer to:Contents1 Music 2 Film and television 3 Other uses 4 See alsoMusic[edit] Special
Special
(album), a 1992
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International Standard Book Number
"ISBN" redirects here. For other uses, see ISBN (other).International Standard Book
Book
NumberA 13-digit ISBN, 978-3-16-148410-0, as represented by an EAN-13 bar codeAcronym ISBNIntroduced 1970; 48 years ago (1970)Managing organisation International ISBN AgencyNo. of digits 13 (formerly 10)Check digit Weighted sumExample 978-3-16-148410-0Website www.isbn-international.orgThe International Standard Book
Book
Number (ISBN) is a unique[a][b] numeric commercial book identifier. Publishers purchase ISBNs from an affiliate of the International ISBN Agency.[1] An ISBN is assigned to each edition and variation (except reprintings) of a book. For example, an e-book, a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, and 10 digits long if assigned before 2007
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PubMed Identifier
PubMed
PubMed
is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine
United States National Library of Medicine
(NLM) at the National Institutes of Health
National Institutes of Health
maintains the database as part of the Entrez
Entrez
system of information retrieval. From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries
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PubMed Central
PubMed
PubMed
Central (PMC) is a free digital repository that archives publicly accessible full-text scholarly articles that have been published within the biomedical and life sciences journal literature. As one of the major research databases within the suite of resources that have been developed by the National Center for Biotechnology Information (NCBI), PubMed
PubMed
Central is much more than just a document repository
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Digital Object Identifier
In computing, a Digital Object Identifier or DOI is a persistent identifier or handle used to uniquely identify objects, standardized by the International Organization for Standardization
International Organization for Standardization
(ISO).[1] An implementation of the Handle System,[2][3] DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos. A DOI aims to be "resolvable", usually to some form of access to the information object to which the DOI refers. This is achieved by binding the DOI to metadata about the object, such as a URL, indicating where the object can be found. Thus, by being actionable and interoperable, a DOI differs from identifiers such as ISBNs and ISRCs which aim only to uniquely identify their referents
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