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Replicon (genetics)
A REPLICON is a DNA
DNA
molecule or RNA
RNA
molecule, or a region of DNA
DNA
or RNA, that replicates from a single origin of replication . CONTENTS * 1 Prokaryotes * 2 Eukaryotes * 3 See also * 4 References PROKARYOTESFor most prokaryotic chromosomes , the replicon is the entire chromosome. One notable exception found comes from archaea , where two Sulfolobus
Sulfolobus
species have been shown to contain three replicons. Examples of bacterial species that have been found to possess multiple replicons include: Rhodobacter sphaeroides (2), Vibrio cholerae
Vibrio cholerae
, and Burkholderia multivorans (3). These "secondary" (or tertiary) chromosomes are often described as a molecule that is a mixture between a true chromosome and a plasmid and are sometimes called "chromids"
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Special
SPECIAL or SPECIALS may refer to: CONTENTS * 1 Music * 2 Film and television * 3 Other uses * 4 See also MUSIC * Special (album) , a 1992 album by Vesta Williams * "Special" (Garbage song) , 1998 * "Special" (Mew song) , 2005 * "Special" (Stephen Lynch song) , 2000 * The Specials
The Specials
, a British band * "Special", a song by Violent Femmes on The Blind Leading the Naked * "Special", a song on
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MCM6
2KLQ, 2LE8 IDENTIFIERS ALIASES MCM6, MCG40308, Mis5, P105MCM, minichromosome maintenance complex component 6 EXTERNAL IDS OMIM: 601806 MGI: 1298227 HomoloGene: 4322 GeneCards: MCM6 GENE LOCATION (HUMAN) CHR. Chromosome
Chromosome
2 (human) BAND 2q21.3 START 135,839,626 bp END 135,876,426 bp GENE LOCATION (MOUSE) CHR
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MCM5
NM_006739 NM_008566 NM_001302540 REFSEQ (PROTEIN)NP_006730 n/a LOCATION (UCSC) Chr 22: 35.4 – 35.43 Mb Chr 8: 75.11 – 75.13 Mb PUBMED SEARCH Wikidata
Wikidata
View/Edit Human View/Edit MouseDNA REPLICATION LICENSING FACTOR MCM5
MCM5
is a protein that in humans is encoded by the MCM5
MCM5
gene . CONTENTS * 1 Function * 2 See also * 3 Interactions * 4 References * 5 Further reading FUNCTIONThe protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation
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International Standard Book Number
The INTERNATIONAL STANDARD BOOK NUMBER (ISBN) is a unique numeric commercial book identifier. An ISBN is assigned to each edition and variation (except reprintings) of a book. For example, an e-book , a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, and 10 digits long if assigned before 2007. The method of assigning an ISBN is nation-based and varies from country to country, often depending on how large the publishing industry is within a country. The initial ISBN configuration of recognition was generated in 1967 based upon the 9-digit STANDARD BOOK NUMBERING (SBN) created in 1966. The 10-digit ISBN format was developed by the International Organization for Standardization (ISO) and was published in 1970 as international standard ISO 2108 (the SBN code can be converted to a ten digit ISBN by prefixing it with a zero)
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Digital Object Identifier
In computing, a DIGITAL OBJECT IDENTIFIER or DOI is a persistent identifier or handle used to uniquely identify objects, standardized by the International Organization for Standardization
International Organization for Standardization
( ISO
ISO
). An implementation of the Handle System , DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos. A DOI aims to be "resolvable", usually to some form of access to the information object to which the DOI refers. This is achieved by binding the DOI to metadata about the object, such as a URL , indicating where the object can be found
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PubMed Central
PUBMED CENTRAL (PMC) is a free digital repository that archives publicly accessible full-text scholarly articles that have been published within the biomedical and life sciences journal literature. As one of the major research databases within the suite of resources that have been developed by the National Center for Biotechnology Information (NCBI), PubMed
PubMed
Central is much more than just a document repository. Submissions into PMC undergo an indexing and formatting procedure which results in enhanced metadata, medical ontology , and unique identifiers which all enrich the XML
XML
structured data for each article on deposit. Content within PMC can easily be interlinked to many other NCBI databases and accessed via Entrez
Entrez
search and retrieval systems, further enhancing the public's ability to freely discover, read and build upon this portfolio of biomedical knowledge
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PubMed Identifier
PUBMED is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health
National Institutes of Health
maintains the database as part of the Entrez
Entrez
system of information retrieval . From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries . PubMed, first released in January 1996, ushered in the era of private, free, home- and office-based MEDLINE searching. The PubMed
PubMed
system was offered free to the public in June 1997, when MEDLINE searches via the Web were demonstrated, in a ceremony, by Vice President Al Gore
Al Gore

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MCM4
NM_005914 NM_182746 NM_008565 REFSEQ (PROTEIN)NP_005905 NP_877423 NP_032591 LOCATION (UCSC) Chr 8: 47.96 – 47.98 Mb Chr 8: 15.62 – 15.64 Mb PUBMED SEARCH Wikidata View/Edit Human View/Edit MouseDNA REPLICATION LICENSING FACTOR MCM4 is a protein that in humans is encoded by the MCM4 gene . CONTENTS * 1 Function * 2 See also * 3 Interactions * 4 References * 5 Further reading FUNCTIONThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme
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DNA
DEOXYRIBONUCLEIC ACID (/diˈɒksiˌraɪboʊnjʊˌkliːɪk, -ˌkleɪɪk/ ( listen ); DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses . DNA
DNA
and ribonucleic acid (RNA) are nucleic acids ; alongside proteins , lipids and complex carbohydrates (polysaccharides ), they are one of the four major types of macromolecules that are essential for all known forms of life . Most DNA
DNA
molecules consist of two biopolymer strands coiled around each other to form a double helix . The two DNA
DNA
strands are called polynucleotides since they are composed of simpler monomer units called nucleotides . Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine , guanine , adenine or thymine ), a sugar called deoxyribose , and a phosphate group
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ORC4
NM_181742 NM_001177313 NM_011958 REFSEQ (PROTEIN) NP_001177808 NP_001177810 NP_001177811 NP_002543 NP_859525NP_859526 NP_001170784 NP_036088 LOCATION (UCSC) Chr 2: 147.93 – 148.02 Mb Chr 2: 48.9 – 48.95 Mb PUBMED SEARCH Wikidata View/Edit Human View/Edit MouseORIGIN RECOGNITION COMPLEX SUBUNIT 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene . CONTENTS * 1 Function * 2 Interactions * 3 References * 4 Further reading FUNCTIONThe origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L
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ORC3
NM_001197259 NM_012381 NM_181837 NM_001159563 NM_015824 REFSEQ (PROTEIN)NP_001184188 NP_036513 NP_862820 NP_001153035 NP_056639 LOCATION (UCSC) Chr 6: 87.59 – 87.67 Mb Chr 6: 34.57 – 34.61 Mb PUBMED SEARCH Wikidata View/Edit Human View/Edit MouseORIGIN RECOGNITION COMPLEX SUBUNIT 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene . CONTENTS * 1 Function * 2 Interactions * 3 References * 4 Further reading FUNCTIONThe origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex
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ORC5
NM_001197292 NM_002553 NM_181747 NM_011959 REFSEQ (PROTEIN)NP_002544 NP_859531 NP_036089 LOCATION (UCSC) Chr 7: 104.13 – 104.21 Mb Chr 7: 22.49 – 22.55 Mb PUBMED SEARCH Wikidata View/Edit Human View/Edit MouseORIGIN RECOGNITION COMPLEX SUBUNIT 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene . CONTENTS * 1 Function * 2 Interactions * 3 References * 4 Further reading FUNCTIONThe origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and 4L
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ORC6
3M03 IDENTIFIERS ALIASES ORC6, ORC6L, origin recognition complex subunit 6 EXTERNAL IDS MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6 GENE ONTOLOGY MOLECULAR FUNCTION • DNA binding • protein binding • DNA replication origin binding CELLULAR COMPONENT • nucleus • membrane • nucleoplasm • origin recognition complex • fibrillar center • nuclear origin of replication recognition complex BIOLOGICAL PROCESS • G1/S transition of mitotic cell cycle • DNA replication • DNA replication initiation • negative regulation of cell division Sources:Amigo / QuickGO RNA EXPRESSION PATTERN More reference
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MCM3
NM_002388 NM_001270472 NM_008563 REFSEQ (PROTEIN)NP_001257401 NP_002379 NP_032589 LOCATION (UCSC) Chr 6: 52.26 – 52.28 Mb Chr 6: 20.8 – 20.82 Mb PUBMED SEARCH Wikidata
Wikidata
View/Edit Human View/Edit MouseDNA REPLICATION LICENSING FACTOR MCM3
MCM3
is a protein that in humans is encoded by the MCM3
MCM3
gene . CONTENTS * 1 Function * 2 Interactions * 3 See also * 4 References * 5 Further reading FUNCTIONThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins
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MCM2
4UUZ, 5BNV, 5BNX, 5BO0, 5C3I, 5JA4 IDENTIFIERS ALIASES MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19, minichromosome maintenance complex component 2, DFNA70 EXTERNAL IDS OMIM: 116945 MGI: 105380 HomoloGene: 3325 GeneCards: MCM2 GENE LOCATION (HUMAN) CHR. Chromosome 3 (human) BAND 3q21.3 START 127,598,223 bp END 127,622,436 bp GENE LOCATION (MOUSE) CHR
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