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Malaise
As a medical term, malaise is a feeling of general discomfort, uneasiness or lack of wellbeing and often the first sign of an infection or other disease. The word has existed in French since at least the 12th century. The term is often used figuratively in other contexts, in addition to its meaning as a general state of angst or melancholy. Cause Malaise is a non-specific symptom and can be present in the slightest ailment, such as an emotion (causing fainting, a vasovagal response) or hunger (light hypoglycemia), to the most serious conditions (cancer, stroke, heart attack, internal bleeding, etc.). Malaise expresses a patient's uneasiness that "something is not right" that may need a medical examination to determine the significance. Malaise is thought to be caused by the activation of an immune response, and the associated pro-inflammatory cytokines. Figurative use " Economic malaise" refers to an economy that is stagnant or in recession (compare depression). T ...
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Malaise Era
Malaise era is a term describing U.S.-market cars from roughly 1973 to 1983. The U.S. federal government released several mandates to reduce pollution and improve the fuel efficiency and safety of cars in this era, which while successful, ultimately resulted in the death of the 1960s-style American muscle car, a marked drop in performance in most American vehicles, and a change in visual styling away from 1960s design cues to generally less popular stylings in the 1970s. Origin of the term The term "malaise era", coined by journalist Murilee Martin, refers to U.S. President Jimmy Carter's malaise speech in which he discussed America's failure to deal with the 1979 oil crisis. Martin claimed the era began in 1973, when the U.S. government released new crash bumper regulations, and ended in 1983, when the Ford Mustang saw a significant performance increase after almost a decade of low performance. The term has since entered wider use, being seen in numerous automotive blogs as ...
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Jimmy Carter
James Earl Carter Jr. (born October 1, 1924) is an American politician who served as the 39th president of the United States from 1977 to 1981. A member of the Democratic Party (United States), Democratic Party, he previously served as the 76th governor of Georgia from 1971 to 1975 and as a Georgia state senator from 1963 to 1967. Since leaving office, Carter has remained engaged in political and social projects, receiving the Nobel Peace Prize in 2002 for his humanitarian work. Born and raised in Plains, Georgia, Carter graduated from the United States Naval Academy in 1946 with a Bachelor of Science degree and joined the United States Navy, serving on numerous submarines. After the death of his father in 1953, he left his naval career and returned home to Plains, where he assumed control of his family's peanut-growing business. He inherited little, due to his father's forgiveness of debts and the division of the estate amongst himself and his siblings. Nevertheless, his ...
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Pediatrics
Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the age of 18. The American Academy of Pediatrics recommends people seek pediatric care through the age of 21, but some pediatric subspecialists continue to care for adults up to 25. Worldwide age limits of pediatrics have been trending upward year after year. A medical doctor who specializes in this area is known as a pediatrician, or paediatrician. The word ''pediatrics'' and its cognates mean "healer of children," derived from the two Greek words: (''pais'' "child") and (''iatros'' "doctor, healer"). Pediatricians work in clinics, research centers, universities, general hospitals and children's hospitals, including those who practice pediatric subspecialties (e.g. neonatology requires resources available in a NICU). History The earli ...
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Vasovagal Response
Reflex syncope is a brief loss of consciousness due to a neurologically induced drop in blood pressure and/or a decrease in heart rate. Before an affected person passes out, there may be sweating, a decreased ability to see, or ringing in the ears. Occasionally, the person may twitch while unconscious. Complications of reflex syncope include injury due to a fall. Reflex syncope is divided into three types: vasovagal, situational, and carotid sinus. Vasovagal syncope is typically triggered by seeing blood, pain, emotional stress, or prolonged standing. Situational syncope is often triggered by urination, swallowing, or coughing. Carotid sinus syncope is due to pressure on the carotid sinus in the neck. The underlying mechanism involves the nervous system slowing the heart rate and dilating blood vessels, resulting in low blood pressure and thus not enough blood flow to the brain. Diagnosis is based on the symptoms after ruling out other possible causes. Recovery from a ...
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Herman Kahn
Herman Kahn (February 15, 1922 – July 7, 1983) was a founder of the Hudson Institute and one of the preeminent futurists of the latter part of the twentieth century. He originally came to prominence as a military strategist and systems theorist while employed at the RAND Corporation. He became known for analyzing the likely consequences of nuclear war and recommending ways to improve survivability, making him one of the historical inspirations for the title character of Stanley Kubrick's classic black comedy film satire '' Dr. Strangelove''.Paul Boyer, 'Dr. Strangelove' in Mark C. Carnes (ed.), ''Past Imperfect: History According to the Movies'', New York, 1996. In his commentary for ''Fail Safe'', director Sidney Lumet remarked that the Professor Groeteschele character is also based on Herman Kahn. Kahn's theories contributed heavily to the development of the nuclear strategy of the United States. Background Kahn was born in Bayonne, New Jersey, the son of Yetta (née K ...
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Depression (economics)
An economic depression is a period of carried long-term economical downturn that is result of lowered economic activity in one major or more national economies. Economic depression maybe related to one specific country were there is some economic crisis that has worsened but most often reflexes historically the American Great Depression and similar economic status that may be recognized as existing at some country, several countries or even in many countries. It is often understood in economics that economic crisis and the following recession that maybe named economic depression are part of economic cycles where slowdown of economy follows the economic growth and vice versa. It is a result of more severe economic problems or a ''downturn'' than the recession itself, which is a slowdown in economic activity over the course of the normal business cycle of growing economy. Economic depressions maybe also characterized by their length or duration, and maybe showing increases in unemplo ...
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Recession
In economics, a recession is a business cycle contraction when there is a general decline in economic activity. Recessions generally occur when there is a widespread drop in spending (an adverse demand shock). This may be triggered by various events, such as a financial crisis, an external trade shock, an adverse supply shock, the bursting of an economic bubble, or a large-scale Anthropogenic hazard, anthropogenic or natural disaster (e.g. a pandemic). In the United States, a recession is defined as "a significant decline in economic activity spread across the market, lasting more than a few months, normally visible in real GDP, real income, employment, industrial production, and wholesale-retail sales." The European Union has adopted a similar definition. In the United Kingdom, a recession is defined as negative economic growth for two consecutive quarters. Governments usually respond to recessions by adopting expansionary macroeconomic policies, such as monetary policy, incr ...
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Economic Malaise
Economic stagnation is a prolonged period of slow economic growth (traditionally measured in terms of the GDP growth), usually accompanied by high unemployment. Under some definitions, "slow" means significantly slower than potential growth as estimated by macroeconomists, even though the growth rate may be nominally higher than in other countries not experiencing economic stagnation. Secular stagnation theory The term "secular stagnation" was originally coined by Alvin Hansen in 1938 to "describe what he feared was the fate of the American economy following the Great Depression of the early 1930s: a check to economic progress as investment opportunities were stunted by the closing of the frontier and the collapse of immigration". Warnings similar to secular stagnation theory have been issued after all deep recessions, but they usually turned out to be wrong because they underestimated the potential of existing technologies.Pagano and Sbracia (2014"The secular stagnation hypo ...
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Cytokines
Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrine signaling, autocrine, paracrine signaling, paracrine and endocrine signaling as Immunomodulation, immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors (despite some growth factor#cytokine, overlap in the terminology). Cytokines are produced by a broad range of cells, including immune cells like macrophages, B cell, B lymphocytes, T cell, T lymphocytes and mast cells, as well as Endothelium, endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the ...
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