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History Of Neuraxial Anesthesia
The history of neuraxial anesthesia goes back to 1885. 19th century In 1855, Friedrich Gaedcke (18281890) became the first to chemically isolate cocaine, the most potent alkaloid of the coca plant. Gaedcke named the compound "erythroxyline". In 1884, Austrian ophthalmologist Karl Koller (18571944) instilled a 2% solution of cocaine into his own eye and tested its effectiveness as a local anesthetic by pricking the eye with needles. His findings were presented a few weeks later at annual conference of the Heidelberg Ophthalmological Society. The following year, William Halsted (18521922) performed the first brachial plexus block. Also in 1885, James Leonard Corning (18551923) injected cocaine between the spinous processes of the lower lumbar vertebrae, first in a dog and then in a healthy man. His experiments are the first published descriptions of the principle of neuraxial blockade. On August 16, 1898, German surgeon August Bier (18611949) performed surgery under spinal a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Leonard Corning
James Leonard Corning (1855 – 1923) was an American neurologist, mainly known for his early experiments on neuraxial blockade in New York City. Education Corning was born in Stamford, Connecticut. When the American Civil War began in 1861, Corning's family moved to Stuttgart, Germany. Corning studied chemistry at the Stuttgart Polytechnic Institute under Hermann von Fehling. He later studied physiology at Heidelberg University under Wilhelm Kühne, and pathology at the University of Würzburg. After receiving his medical degree in 1878, he left Germany and visited Vienna, Paris, and London before finally returning to the United States. Neuraxial blockade In 1884, Karl Koller became the first to describe the anesthetic properties of cocaine. The following year, Corning injected cocaine between the spinous processes of the lower lumbar vertebrae, first in a dog and then in a healthy man. His experiments are the first published descriptions of the principle of neuraxial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kiel
Kiel () is the capital and most populous city in the northern German state of Schleswig-Holstein, with a population of 246,243 (2021). Kiel lies approximately north of Hamburg. Due to its geographic location in the southeast of the Jutland peninsula on the southwestern shore of the Baltic Sea, Kiel has become one of Germany's major maritime centres, known for a variety of international sailing events, including the annual Kiel Week, which is the biggest sailing event in the world. Kiel is also known for the Kiel Mutiny, when sailors refused to board their vessels in protest against Germany's further participation in World War I, resulting in the abdication of the Kaiser and the formation of the Weimar Republic. The Olympic sailing competitions of the 1936 and the 1972 Summer Olympics were held in the Bay of Kiel. Kiel has also been one of the traditional homes of the German Navy's Baltic fleet, and continues to be a major high-tech shipbuilding centre. Located in Kiel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fidel Pagés Visiting An Injured Person In Melilla In The 1909 Campaign
Fidel most commonly refers to: * Fidel Castro (1926–2016), Cuban communist revolutionary and politician * Fidel Ramos (1928–2022), Filipino politician and former president Fidel may also refer to: Other persons * Fidel (given name) Film * ''Fidel'' (2002 film), a 2002 mini-series by David Attwood about Castro * ''Fidel'' (2009 film), a 2009 Filipino indie film * '' Fidel: The Untold Story'', a 2001 a documentary about Castro Other uses * Fidel, a writing system used in Ethiopia and Eritrea, see Ge'ez script * Vielle, a musical instrument and forerunner of the fiddle * Fidel (imprint) Omniscriptum Publishing Group, formerly known as VDM Verlag Dr. Müller, is a German publishing group headquartered in Riga, Latvia. Founded in 2002 in Düsseldorf, its book production is based on print-to-order technology. The company publis ..., an imprint of VDM Publishing devoted to the reproduction of Wikipedia content See also * Fidèle (other) {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tecnica
Tecnica Group is a sport equipment manufacturer in the market of footwear and winter sports equipment founded in Giavera del Montello, Treviso, Italy. Tecnica Group brands include Blizzard, Lowa, Moon Boot, Nordica, Rollerblade, and Tecnica. History Tecnica Group was established in the 1960s. Over the years several additional brands became part of the Group and today it covers various product categories, specifically footwear, ski boots, skis, outdoor and inline skates. In 1930 Oreste Zanatta founded a small shop focused on working boots production, that officially became in 1960 the Calzaturificio Tecnica SpA. Over the following ten years, Tecnica expanded its business and created the first Moon Boot. In 1985 Tecnica entered the outdoor footwear market. This happened through the purchase, in 1993, of LOWA, the historical outdoor shoemaker in Germany. In 2002, with the acquisition of Nordica, Tecnica Group became the first world producer of ski boots. In 2003, the p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vein
Veins are blood vessels in humans and most other animals that carry blood towards the heart. Most veins carry deoxygenated blood from the tissues back to the heart; exceptions are the pulmonary and umbilical veins, both of which carry oxygenated blood to the heart. In contrast to veins, arteries carry blood away from the heart. Veins are less muscular than arteries and are often closer to the skin. There are valves (called ''pocket valves'') in most veins to prevent backflow. Structure Veins are present throughout the body as tubes that carry blood back to the heart. Veins are classified in a number of ways, including superficial vs. deep, pulmonary vs. systemic, and large vs. small. * Superficial veins are those closer to the surface of the body, and have no corresponding arteries. * Deep veins are deeper in the body and have corresponding arteries. * Perforator veins drain from the superficial to the deep veins. These are usually referred to in the lower limbs and feet. * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinal Cord
The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spinal cord, which contains cerebrospinal fluid. The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital bone, passing through the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae. The spinal cord extends down to between the first and second lumbar vertebrae, where it ends. The enclosing bony vertebral column protects the relatively shorter spinal cord. It is around long in adult men and around long in adult women. The diameter of the spinal cord ranges from in the cervical and lumbar regions to in the thoracic area. The spinal cord functions primarily in the transmission of nerve signals from the motor cortex to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinal Nerve
A spinal nerve is a mixed nerve, which carries motor, sensory, and autonomic signals between the spinal cord and the body. In the human body there are 31 pairs of spinal nerves, one on each side of the vertebral column. These are grouped into the corresponding cervical, thoracic, lumbar, sacral and coccygeal regions of the spine. There are eight pairs of cervical nerves, twelve pairs of thoracic nerves, five pairs of lumbar nerves, five pairs of sacral nerves, and one pair of coccygeal nerves. The spinal nerves are part of the peripheral nervous system. Structure Each spinal nerve is a mixed nerve, formed from the combination of nerve fibers from its dorsal and ventral roots. The dorsal root is the afferent sensory root and carries sensory information to the brain. The ventral root is the efferent motor root and carries motor information from the brain. The spinal nerve emerges from the spinal column through an opening ( intervertebral foramen) between adjacent verteb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mechanism Of Action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there. Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are antacids and laxatives. In contrast, a mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance. Importance Elucidating the mechanism of action of novel drugs and medications is important for several reasons: * In the case of anti-infec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subarachnoid Space
In anatomy, the meninges (, ''singular:'' meninx ( or ), ) are the three membranes that envelop the brain and spinal cord. In mammals, the meninges are the dura mater, the arachnoid mater, and the pia mater. Cerebrospinal fluid is located in the subarachnoid space between the arachnoid mater and the pia mater. The primary function of the meninges is to protect the central nervous system. Structure Dura mater The dura mater ( la, tough mother) (also rarely called ''meninx fibrosa'' or ''pachymeninx'') is a thick, durable membrane, closest to the skull and vertebrae. The dura mater, the outermost part, is a loosely arranged, fibroelastic layer of cells, characterized by multiple interdigitating cell processes, no extracellular collagen, and significant extracellular spaces. The middle region is a mostly fibrous portion. It consists of two layers: the endosteal layer, which lies closest to the skull, and the inner meningeal layer, which lies closer to the brain. It contains ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidural Space
In anatomy, the epidural space is the potential space between the dura mater and vertebrae (spine). The anatomy term "epidural space" has its origin in the Ancient Greek language; , "on, upon" + dura mater also known as "epidural cavity", "extradural space" or "peridural space". In humans the epidural space contains lymphatics, spinal nerve roots, loose connective tissue, adipose tissue, small arteries, dural venous sinuses and a network of internal vertebral venous plexuses. Cranial epidural space In the skull, the periosteal layer of the dura mater adheres to the inner surface of the skull bones while the meningeal layer lays over the arachnoid mater. Between them is the epidural space. The two layers of the dura mater separate at several places, with the meningeal layer projecting deeper into the brain parenchyma forming fibrous septa that compartmentalize the brain tissue. At these sites, the epidural space is wide enough to house the epidural venous sinuses. There are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. There is about 125 mL of CSF at any one time, and about 500 mL is generated every day. CSF acts as a shock absorber, cushion or buffer, providing basic mechanical and immunological protection to the brain inside the skull. CSF also serves a vital function in the cerebral autoregulation of cerebral blood flow. CSF occupies the subarachnoid space (between the arachnoid mater and the pia mater) and the ventricular system around and inside the brain and spinal cord. It fills the ventricles of the brain, cisterns, and sulci, as well as the central canal of the spinal cord. There is also a connection from the subarachnoid space to the bony labyrinth of the inner ear via the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatome (anatomy)
A dermatome is an area of skin that is mainly supplied by afferent nerve fibres from the dorsal root of any given spinal nerve. There are 8 cervical nerves (C1 being an exception with no dermatome), 12 thoracic nerves, 5 lumbar nerves and 5 sacral nerves. Each of these nerves relays sensation (including pain) from a particular region of skin to the brain. The term is also used to refer to a part of an embryonic somite. Along the thorax and abdomen the dermatomes are like a stack of discs forming a human, each supplied by a different spinal nerve. Along the arms and the legs, the pattern is different: the dermatomes run longitudinally along the limbs. Although the general pattern is similar in all people, the precise areas of innervation are as unique to an individual as fingerprints. An area of skin innervated by a single nerve is called a peripheral nerve field. The word ''dermatome'' is formed from Ancient Greek δέρμα 'skin, hide' and τέμνω 'cut'. Clinical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
