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History Of Biotechnology
Biotechnology is the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services. From its inception, biotechnology has maintained a close relationship with society. Although now most often associated with the development of drugs, historically biotechnology has been principally associated with food, addressing such issues as malnutrition and famine. The history of biotechnology begins with zymotechnology, which commenced with a focus on brewing techniques for beer. By World War I, however, zymotechnology would expand to tackle larger industrial issues, and the potential of industrial fermentation gave rise to biotechnology. However, both the single-cell protein and gasohol projects failed to progress due to varying issues including public resistance, a changing economic scene, and shifts in political power. Yet the formation of a new field, genetic engineering, would soon bring biotechnology to the forefr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Brewer Designed And Engraved In The Sixteenth
''The'' () is a grammatical article in English, denoting persons or things already mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with pronouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when followed by a consonant sound, and as (homophone of pronoun '' thee'') when followed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetically Modified Food
Genetically modified foods (GM foods), also known as genetically engineered foods (GE foods), or bioengineered foods are foods produced from organisms that have had changes introduced into their DNA using the methods of genetic engineering. Genetic engineering techniques allow for the introduction of new traits as well as greater control over traits when compared to previous methods, such as selective breeding and mutation breeding. The discovery of DNA and the improvement of genetic technology in the 20th century played a crucial role in the development of transgenic technology. In 1988, genetically modified microbial enzymes were first approved for use in food manufacture. Recombinant rennet was used in few countries in the 1990s. Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its unsuccessful Flavr Savr delayed-ripening tomato.Weasel, Lisa H. 2009. ''Food Fray''. Amacom Publishing Most food modifications have primarily focused on cash ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cortisone
Cortisone is a pregnene (21-carbon) steroid hormone. It is a naturally-occurring corticosteroid metabolite that is also used as a pharmaceutical prodrug; it is not synthesized in the adrenal glands. Cortisol is converted by the action of the enzyme corticosteroid 11-beta-dehydrogenase isozyme 2 into the inactive metabolite cortisone, particularly in the kidneys. Cortisone is converted back to the active steroid cortisol by the action of the enzyme 11β-Hydroxysteroid dehydrogenase type 1, particularly in the liver. The term "cortisone" is frequently misused to mean either any corticosteroid or hydrocortisone, which is actually another name for cortisol. Many who speak of receiving a "cortisone shot" or taking "cortisone" are actually receiving hydrocortisone or one of many other, much more potent synthetic corticosteroids; it is unlikely that the drug administered is actually cortisone. Cortisone can be administered as a prodrug, meaning it has to be converted by the body (spe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Semisynthesis
Semisynthesis, or partial chemical synthesis, is a type of chemical synthesis that uses chemical compounds isolated from natural sources (such as microbial cell cultures or plant material) as the starting materials to produce novel compounds with distinct chemical and medicinal properties. The novel compounds generally have a high molecular weight or a complex molecular structure, more so than those produced by total synthesis from simple starting materials. Semisynthesis is a means of preparing many medicines more cheaply than by total synthesis since fewer chemical steps are necessary. Overview Drugs derived from natural sources are usually produced by isolation from the natural source or, as described here, by semisynthesis from such an isolated agent. From the viewpoint of chemical synthesis, living organisms are remarkable chemical factories that can easily produce structurally-complex chemical compounds by biosynthesis. In contrast, engineered chemical synthesis is necess ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroids
A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol ( opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene. The steroid core structure is typically composed of seventeen carbon atoms, bonded in four " fused" rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from chol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from '' Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prohibition
Prohibition is the act or practice of forbidding something by law; more particularly the term refers to the banning of the manufacture, storage (whether in barrels or in bottles), transportation, sale, possession, and consumption of alcoholic beverages. The word is also used to refer to a period of time during which such bans are enforced. History Some kind of limitation on the trade in alcohol can be seen in the Code of Hammurabi (c. 1772 BCE) specifically banning the selling of beer for money. It could only be bartered for barley: "If a beer seller do not receive barley as the price for beer, but if she receive money or make the beer a measure smaller than the barley measure received, they shall throw her into the water." In the early twentieth century, much of the impetus for the prohibition movement in the Nordic countries and North America came from moralistic convictions of pietistic Protestants. Prohibition movements in the West coincided with the advent of women ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Károly Ereky
Károly Ereky (german: Karl Ereky; 20 October 1878 – 17 June 1952) was a Hungarian agricultural engineer. The term 'biotechnology' was coined by him in 1919. He is regarded by some as the "father" of biotechnology. Early life Ereky was born on 18 October 1878 in Esztergom, Hungary as Károly Wittmann. His father was István Wittmann and his mother Mária Dukai Takách. (Among her relatives was Judit Dukai Takách (1795-1836) who was the first Hungarian female poet.) In 1893 he changed his name to Ereky. He had three brothers: Jenő, Ferenc and István. Ereky finished grammar school at Sümeg and Székesfehérvár. He attended the Technical University of Budapest and in 1900 received a degree in technical engineering. There may be a family connection between Ereky and compatriot Franz Wittmann, prominent electrical engineer and inventor of the Wittmann-oscilloscope. Career He then worked as machine designer for several paper and food industry companies in Vienna, Austria unt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Industrial Fermentation
Industrial fermentation is the intentional use of fermentation in manufacturing products useful to humans. In addition to the mass production of fermented foods and drinks, industrial fermentation has widespread applications in chemical industry. Commodity chemicals, such as acetic acid, citric acid, and ethanol are made by fermentation. Moreover, nearly all commercially produced industrial enzymes, such as lipase, invertase and rennet, are made by fermentation with genetically modified microbes. In some cases, production of biomass itself is the objective, as is the case for single-cell proteins, baker's yeast, and starter cultures for lactic acid bacteria used in cheesemaking. In general, fermentations can be divided into four types: * Production of biomass (viable cellular material) * Production of extracellular metabolites (chemical compounds) * Production of intracellular components (enzymes and other proteins) * Transformation of substrate (in which the transformed sub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cordite
Cordite is a family of smokeless propellants developed and produced in the United Kingdom since 1889 to replace black powder as a military propellant. Like modern gunpowder, cordite is classified as a low explosive because of its slow burning rates and consequently low brisance. These produce a subsonic deflagration wave rather than the supersonic detonation wave produced by brisants, or high explosives. The hot gases produced by burning gunpowder or cordite generate sufficient pressure to propel a bullet or shell to its target, but not so quickly as to routinely destroy the barrel of the gun. Cordite was used initially in the .303 British, Mark I and II, standard rifle cartridge between 1891 and 1915; shortages of cordite in World War I led to the creation of the "Devil's Porridge" munitions factory ( HM Factory, Gretna) on the English-Scottish border, which produced 800 tonnes of cordite per annum. The UK also imported some United States–developed smokeless powders f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetone
Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscible with water and serves as an important organic solvent in its own right, in industry, home, and laboratory. About 6.7 million tonnes were produced worldwide in 2010, mainly for use as a solvent and production of methyl methacrylate (and from that PMMA) as well as bisphenol A.Acetone World Petrochemicals report, January 2010Stylianos Sifniades, Alan B. Levy, "Acetone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. It is a common building block in |
Chaim Weizmann
Chaim Azriel Weizmann ( he, חיים עזריאל ויצמן ', russian: Хаим Евзорович Вейцман, ''Khaim Evzorovich Veytsman''; 27 November 1874 – 9 November 1952) was a Russian-born biochemist, Zionist leader and Israeli statesman who served as president of the Zionist Organization and later as the first president of Israel. He was elected on 16 February 1949, and served until his death in 1952. Weizmann was fundamental in obtaining the Balfour Declaration and later convincing the United States government to recognize the newly formed State of Israel. As a biochemist, Weizmann is considered to be the 'father' of industrial fermentation. He developed the acetone–butanol–ethanol fermentation process, which produces acetone, n-butanol and ethanol through bacterial fermentation. His acetone production method was of great importance in the manufacture of cordite explosive propellants for the British war industry during World War I. He founded the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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