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Cajal , a tiny lunar impact crater
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Cajal: * Santiago Ramón y Cajal, Spanish histologist, physician, pathologist * Fortún Garcés Cajal, medieval Spanish nobleman * Nicolae Cajal (1919–2004), Romanian Jewish physician, academic, politician, philanthropist * Cajal Institute, a neuroscience research center in Madrid, Spain. * Cajal cells ** Cajal–Retzius cell ** Interstitial cell of Cajal (ICC) * Cajal bodies (CBs) * Cajal (crater) Cajal is a small lunar impact crater on the northern part of the Mare Tranquilitatis. It was named after the Spanish doctor and Nobel laureate Santiago Ramón y Cajal. It is a circular (9 km diameter), cup-shaped formation that lies southeast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santiago Ramón Y Cajal
Santiago Ramón y Cajal (; 1 May 1852 – 17 October 1934) was a Spanish neuroscientist, pathologist, and histologist specializing in neuroanatomy and the central nervous system. He and Camillo Golgi received the Nobel Prize in Physiology or Medicine in 1906. Ramón y Cajal was the first person of Spanish origin to win a scientific Nobel Prize. His original investigations of the microscopic structure of the brain made him a pioneer of modern neuroscience. Hundreds of his drawings illustrating the arborizations ("tree growing") of brain cells are still in use, since the mid-20th century, for educational and training purposes. Biography Santiago Ramón y Cajal was born on the 1st of May 1852 in the town of Petilla de Aragón, Navarre, Spain. As a child he was transferred many times from one school to another because of behavior that was declared poor, rebellious, and showing an anti- authoritarian attitude. An extreme example of his precociousness and rebelliousness at the ag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cajal–Retzius Cell
Cajal–Retzius cells (CR cells) (also known as Horizontal cells of Cajal) are a heterogeneous population of morphologically and molecularly distinct reelin-producing cell types in the marginal zone/layer I of the developmental cerebral cortex and in the immature hippocampus of different species and at different times during embryogenesis and postnatal life. These cells were discovered by two scientists, Santiago Ramón y Cajal and Gustaf Retzius, at two different times and in different species. They are originated in the developing brain in multiple sites within the neocortex and hippocampus. From there, Cajal–Retzius (CR) cells migrate through the marginal zone, originating the layer I of the cortex. As these cells are involved in the correct organization of the developing brain, there are several studies implicating CR cells in neurodevelopmental disorders, especially schizophrenia, bipolar disorder, autism, lissencephaly and temporal lobe epilepsy. Development In 1971 it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cajal Body
Cajal bodies (CBs) also coiled bodies, are spherical nuclear bodies of 0.3–1.0 µm in diameter found in the nucleus of proliferative cells like embryonic cells and tumor cells, or metabolically active cells like neurons. CBs are membrane-less organelles and largely consist of proteins and RNA. They were first reported by Santiago Ramón y Cajal in 1903, who called them ''nucleolar accessory bodies'' due to their association with the nucleoli in neuronal cells. They were rediscovered with the use of the electron microscope (EM) and named ''coiled bodies'', according to their appearance as coiled threads on EM images, and later renamed after their discoverer. Research on CBs was accelerated after discovery and cloning of the marker protein p80/Coilin. CBs have been implicated in RNA-related metabolic processes such as the biogenesis, maturation and recycling of snRNPs, histone mRNA processing and telomere maintenance. CBs assemble RNA which is used by telomerase to add nucleo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fortún Garcés Cajal
Fortún Garcés Cajal (died 1146) was a Navarro- Aragonese nobleman and statesman, perhaps "the greatest noble of Alfonso the Battler's reign". He was very wealthy in both land and money, and could raise two to three hundred knights for his retinue, funded both out of his treasury and enfeoffed on his lands. In 1113 Fortún replaced Diego López I de Haro in the large and important tenancy of Nájera and Viguera. He held it until 1135. After the death of Alfonso the Battler in 1134, Fortún became a vassal of King Alfonso VII of Castile. Lordships Fortún was probably born around 1075. Nothing is known of his life before he appears at the court of Alfonso the Battler in 1110. In that year he witnessed Alfonso's arbitration of a dispute between the diocese of Pamplona and the abbey of Saint-Sernin at Toulouse over possession of the church of Artajona. Thereafter, Fortún's rise was rapid. As a servant of the crown, Fortún held several lordships (''tenencias''), compact terr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cajal Institute
The Cajal Institute (IC) is a research center in neurobiology which belongs to the Spanish National Research Council (CSIC). The IC originates from the ''Laboratorio de Investigaciones Biológicas'', founded in 1900 by order of King Alfonso XIII on the occasion of the Moscow Prize to Santiago Ramón y Cajal (1852–1934). Following Cajal's award of the Nobel Prize in Physiology and Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, according ... in 1906 and the 1907 creation of the ''Junta de Ampliación de Estudios'', Cajal was appointed President of the Junta. A royal decree by king Alfonso XIII established the construction of a new building and the appointment of Cajal as its first director in 1920. The building, finally inaugurated in 1932, was located in the hill of San Blas and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interstitial Cell Of Cajal
Interstitial cells of Cajal (ICC) are interstitial cells found in the gastrointestinal tract. There are different types of ICC with different functions. ICC and another type of interstitial cell, known as platelet-derived growth factor receptor alpha (PDGFRα) cells, are electrically coupled to smooth muscle cells via gap junctions, that work together as an SIP functional syncytium. Myenteric interstitial cells of Cajal (ICC-MY) serve as pacemaker cells that generate the bioelectrical events known as slow waves. Slow waves conduct to smooth muscle cells and cause phasic contractions. The picture to the right shows an isolated Interstitial cell of Cajal from the Myenteric plexus of the mouse small intestine grown in a primary cell culture. This cell type can be characterized morphologically as having a small cell body often triangular or stellate-shaped with several long processes branching out into secondary and tertiary extensions - these processes often contact smooth muscle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicolae Cajal
Nicolae Cajal (October 1, 1919, in Bucharest – March 7, 2004) was a Romanian Jewish physician, academic, politician, and philanthropist. He was President of the Jewish Communities' Federation of Romania from 1994 to his death. Biography Cajal held a Ph.D. degree in virology and chaired the ''Ștefan S. Nicolau Virology Research Center'' in Bucharest for years. He was a Member of the Romanian Academy, the Romanian Medical Sciences Academy, the British Royal Society of Medicine, and the New York Academy of Sciences. From 1966, he was an expert for the World Health Organization. In 1944, Cajal worked as an intern in the hospital laboratories, in the laboratories of the bacteriology department of the Medical Faculty of Bucharest, and since 1945 at the department of inframicrobiology - virusology. As a specialist in virology, Cajal was a disciple of Ștefan S. Nicolau, founder of the Romanian School of Virology. His contributions were published in over 400 scientific papers. In 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Astrocyte
Astrocytes (from Ancient Greek , , "star" + , , "cavity", "cell"), also known collectively as astroglia, are characteristic star-shaped glial cells in the brain and spinal cord. They perform many functions, including biochemical control of endothelial cells that form the blood–brain barrier, provision of nutrients to the nervous tissue, maintenance of extracellular ion balance, regulation of cerebral blood flow, and a role in the repair and scarring process of the brain and spinal cord following infection and traumatic injuries. The proportion of astrocytes in the brain is not well defined; depending on the counting technique used, studies have found that the astrocyte proportion varies by region and ranges from 20% to 40% of all glia. Another study reports that astrocytes are the most numerous cell type in the brain. Astrocytes are the major source of cholesterol in the central nervous system. Apolipoprotein E transports cholesterol from astrocytes to neurons and other glia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
