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Brockham
Brockham is a village and civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, with the River Mole flowing west through the village. At the 2011 census, it had a population of 2,868.Key Statistics; Quick Statistics: Population Density '''' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend in a brook) is so ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brockham Park
Brockham is a village and civil parishes in England, civil parish in the Mole Valley district of Surrey, England. It is approximately east of Dorking and west of Reigate. The village lies south of Box Hill, Surrey, Box Hill, with the River Mole, Surrey, River Mole flowing west through the village. At the 2011 census, it had a population of 2,868.Key Statistics; Quick Statistics: Population Density United Kingdom Census 2011 ''Office for National Statistics'' Retrieved 21 November 2013 Name Brockham, originally 'Brook-ham' (bend in a brook) is so called from the Anglo Saxon meaning 'river meadow by the brook' and is first recorded in 1241. It is often mistakenly believed that there is an association with badgers but this is a modern affectation from the 1950s when Cecily M Rutley creat ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Box Hill, Surrey
Box Hill is a summit of the North Downs in Surrey, approximately south-west of London. The hill gets its name from the ancient box woodland found on the steepest west-facing chalk slopes overlooking the River Mole. The western part of the hill is owned and managed by the National Trust, whilst the village of Box Hill lies on higher ground to the east. The highest point is Betchworth Clump at above OD, although the Salomons Memorial (at 172 metres) overlooking the town of Dorking is the most popular viewpoint. Box Hill lies within the Surrey Hills Area of Outstanding Natural Beauty and forms part of the Mole Gap to Reigate Escarpment Site of Special Scientific Interest. The north- and south-facing slopes support an area of chalk downland, noted for its orchids and other rare plant species. The hill provides a habitat for 38 species of butterfly, and has given its name to a species of squash bug, now found throughout south-east England. An estimated 850,000 people visit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
River Mole, Surrey
The River Mole is a tributary of the River Thames in southern England. It rises in West Sussex near Gatwick Airport and flows northwest through Surrey for to the Thames at Hampton Court Palace. The river gives its name to the Surrey district of Mole Valley. The Mole crosses the North Downs between Dorking and Leatherhead, where it cuts a steep-sided valley, known as the Mole Gap, through the chalk. Much of the catchment area lies on impermeable rock (including Weald Clay and London Clay), meaning that the river level responds rapidly to heavy rainfall. During the second half of the 20th century pollution levels in the river were high; however, since 1995 the water quality has improved dramatically and the Mole now boasts the greatest diversity of fish species of any river in England. Twelve Sites of Special Scientific Interest (SSSIs) that include wetland habitats are located within the Mole catchment area, and the stretch of river through Leatherhead has been designated a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dorking
Dorking () is a market town in Surrey in South East England, about south of London. It is in Mole Valley, Mole Valley District and the non-metropolitan district, council headquarters are to the east of the centre. The High Street runs roughly east–west, parallel to the Pipp Brook and along the northern face of an outcrop of Lower Greensand Group, Lower Greensand. The town is surrounded on three sides by the Surrey Hills AONB, Surrey Hills Area of Outstanding Natural Beauty and is close to Box Hill, Surrey, Box Hill and Leith Hill. The earliest archaeological evidence of human activity is from the Mesolithic and Neolithic periods, and there are several Bronze Age bowl barrows in the local area. The town may have been the site of a staging post on Stane Street (Chichester), Stane Street during Roman Britain, Roman times, however the name 'Dorking' suggests an History of Anglo-Saxon England, Anglo-Saxon origin for the modern settlement. A marketplace, market is thought to have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beecham Group
The Beecham Group plc was a British pharmaceutical company. It was once a constituent of the FTSE 100 Index. Beecham, after having merged with American pharmaceutical company SmithKline Beckman to become SmithKline Beecham, merged with Glaxo Wellcome to become GlaxoSmithKline (GSK). GSK still uses the Beechams brand name in the UK for its over-the-counter cold and flu relief products. Early history Beecham began as the family business of Thomas Beecham (1820–1907), a chemist. (Beecham would become the grandfather of music conductor Thomas Beecham, 1879–1961). As a boy, Beecham worked as a shepherd, selling herbal remedies as a sideline. He later became a travelling salesman or peddler full time. His first product was Beecham's Pills, a laxative, in 1842. Subsequent success enabled him to open a shop in Wigan in 1847. Beecham opened its first factory in 1849 in St Helens, Lancashire, for the rapid production of medicines. Under his son, Sir Joseph Beecham, 1st Baronet ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mole Valley
Mole Valley is a local government district in Surrey, England. Its council is based in Dorking. The other town in the district is Leatherhead. The largest villages are Ashtead, Fetcham and Great Bookham, in the northern third of the district. Most of the district is on the escarpments of or adjoins the Surrey Hills AONB (the North Downs and Greensand Ridge including locally Leith Hill, Polesden Lacey, Box Hill and Denbies Wine Estate, the largest vineyard in the country and several golf courses) The North Downs are followed or parallelled by the Pilgrims' Way. There are stations on the London–Worthing and Reading–Gatwick Airport railways, and in the northern third, a commuter stopping-service pattern line, London–Guildford (via Epsom) line. The A24 road and the M25 motorway are the main thoroughfares and relative to London the incidence of car ownership is high. The area hosts hill-focussed sub-laps of the London–Surrey Classic cycling tour each year. Towns * Dor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mole Valley (UK Parliament Constituency)
Mole Valley is a constituency represented in the House of Commons of the UK Parliament since 1997 by Sir Paul Beresford, a Conservative. Boundaries 1983–1997: The District of Mole Valley, and the Borough of Guildford ward of Tillingbourne. 1997–present: The District of Mole Valley wards of Beare Green, Bookham North, Bookham South, Box Hill and Headley, Brockham, Betchworth and Buckland, Capel, Leigh and Newdigate, Charlwood, Dorking North, Dorking South, Fetcham East, Fetcham West, Holmwoods, Leatherhead North, Leatherhead South, Leith Hill, Mickleham, Westhumble and Pixham, Okewood, and Westcott; and the Borough of Guildford wards of Clandon and Horsley, Effingham, Lovelace, Send, and Tillingbourne. The constituency is larger than the Mole Valley district in Surrey as it includes five wards in the east of the Borough of Guildford, three of which are nearer to Woking than to Dorking. The largest town in the constituency is Dorking, second largest is Leatherhead and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
6-APA
6-APA ((+)-6-aminopenicillanic acid) is a chemical compound used as an intermediate in the synthesis of β-lactam antibiotics. The major commercial source of 6-APA is still natural penicillin G: the semi-synthetic penicillins derived from 6-APA are also referred to as penicillins and are considered part of the penicillin family of antibiotics. In 1958, Beecham scientists from Brockham Park, Surrey, found a way to obtain 6-APA from penicillin. Other β-lactam antibiotics could then be synthesized by attaching various side-chains to the nucleus.F.P. Doyle, J.H.C. Nayler, G.N. Rolinson ''US Patent 2,941,995'', filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid. The reason why this was achieved so many years after the commercial development of penicillin by Howard Florey Howard Walter Florey, Baron Florey (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Betchworth Castle
Betchworth Castle is a mostly crumbled ruin of a fortified medieval stone house with some tall, two-storey corners strengthened in the 18th century, in the north of the semi-rural parish of Brockham. It is built on a sandstone spur overlooking the western bank of the River Mole in Surrey in England. The ruin is a Scheduled monument and is in the lowest category of listed architecture, Grade II, due east of Dorking railway station in Dorking and due west of Reigate. Although close to the river and edge of the course it is surrounded by " Betchworth Park" Golf Course named after the village east. In 1798, Henry Peters bought Betchworth Castle and spent considerable money renovating it to be a comfortable family home. Henry lived at Betchworth Castle with his wife, Charlotte Mary Morrison, and his twelve children until his death in 1827. After Henry’s death, Betchworth Castle was not inherited by his children and therefore was bought by David Barclay and later by Henry Hope ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medieval
In the history of Europe, the Middle Ages or medieval period lasted approximately from the late 5th to the late 15th centuries, similar to the post-classical period of global history. It began with the fall of the Western Roman Empire and transitioned into the Renaissance and the Age of Discovery. The Middle Ages is the middle period of the three traditional divisions of Western history: classical antiquity, the medieval period, and the modern period. The medieval period is itself subdivided into the Early, High, and Late Middle Ages. Population decline, counterurbanisation, the collapse of centralized authority, invasions, and mass migrations of tribes, which had begun in late antiquity, continued into the Early Middle Ages. The large-scale movements of the Migration Period, including various Germanic peoples, formed new kingdoms in what remained of the Western Roman Empire. In the 7th century, North Africa and the Middle East—most recently part of the Easte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methicillin
Methicillin ( USAN), also known as meticillin ( INN), is a narrow-spectrum β-lactam antibiotic of the penicillin class. Methicillin was discovered in 1960. Medical uses Compared to other penicillins that face antimicrobial resistance due to β-lactamase, it is less active, can be administered only parenterally, and has a higher frequency of interstitial nephritis, an otherwise-rare adverse effect of penicillins. However, selection of methicillin depended on the outcome of susceptibility testing of the sampled infection, and since it is no longer produced, it is also not routinely tested for any more. It also served a purpose in the laboratory to determine the antibiotic sensitivity of ''Staphylococcus aureus'' to other penicillins facing β-lactam resistance; this role has now been passed on to other penicillins, namely '' cloxacillin'', as well as genetic testing for the presence of ''mecA'' gene by '' PCR''. Spectrum of activity At one time, methicillin was used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from '' Penicillium'' moulds, principally '' P. chrysogenum'' and '' P. rubens''. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth). Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for different bacterial infections, though many types of bacteria have developed resistance following extensive use. 10% of the population claims penicillin allergies but because the frequency of positive skin test results decreases by 10% with each year of avoidance, 90% of these patients can tolerate penicillin. Additionally, those wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
