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(von Zumbusch) Acute Generalized Pustular Psoriasis
von Zumbusch (acute) generalized pustular psoriasis, (acute GPP) is the most severe form of generalized pustular psoriasis, and can be associated with life-threatening complications.[1]Contents1 Signs and symptoms 2 Diagnosis 3 Treatment 4 History 5 ReferencesSigns and symptoms[edit] Patients with acute GPP experience the eruption of multiple isolated sterile pustules generalized over the body, recurrent fevers, fatigue, and laboratory abnormalities (elevated ESR, elevated CRP, combined with leukocytosis).[2] Diagnosis[edit] Kogoj's spongiform pustules can be observed via histopathology to confirm acute GPP.[2] Treatment[edit] Acute GPP typically requires inpatient management including both topical and systemic therapy, and supportive measures.[3] Systemic glucocorticoid withdrawal is a common causative agent.[4] Withdrawal or administration of certain drugs in the patient's previous medication regimen may be required
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International Statistical Classification Of Diseases And Related Health Problems
The International Classification of Diseases (ICD) is the international "standard diagnostic tool for epidemiology, health management and clinical purposes". Its full official name is International Statistical Classification of Diseases and Related Health Problems.[1] The ICD is maintained by the World Health Organization
World Health Organization
(WHO), the directing and coordinating authority for health within the United Nations System.[2] The ICD is designed as a health care classification system, providing a system of diagnostic codes for classifying diseases, including nuanced classifications of a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or disease. This system is designed to map health conditions to corresponding generic categories together with specific variations, assigning for these a designated code, up to six characters long
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ICD-10
ICD-10 is the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD), a medical classification list by the World Health Organization
World Health Organization
(WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases.[1] Work on ICD-10 began in 1983 and was completed in 1992.[1] The code set in the base classification allows for more than 14,400 different codes,[citation needed] and permits the tracking of many new diagnoses compared to ICD-9)
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Erythrocyte Sedimentation Rate
The erythrocyte sedimentation rate (ESR or sed rate) is the rate at which red blood cells sediment in a period of one hour. It is a common hematology test, and is a non-specific measure of inflammation. To perform the test, anticoagulated blood was traditionally placed in an upright tube, known as a Westergren tube, and the rate at which the red blood cells fall was measured and reported in mm at the end of one hour. Since the introduction of automated analyzers into the clinical laboratory, the ESR test has been automatically performed. The ESR is governed by the balance between pro-sedimentation factors, mainly fibrinogen, and those factors resisting sedimentation, namely the negative charge of the erythrocytes (zeta potential). When an inflammatory process is present, the high proportion of fibrinogen in the blood causes red blood cells to stick to each other. The red cells form stacks called 'rouleaux,' which settle faster, due to their increased density
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C-reactive Protein
1B09, 1GNH, 1LJ7, 3L2Y, 3PVN, 3PVOIdentifiersAliases CRP, PTX1, C-reactive protein, pentraxin-related, C-Reactive ProteinExternal IDs OMIM: 123260 MGI: 88512 HomoloGene: 128039 GeneCards: CRPGene location (Human)Chr. Chromosome
Chromosome
1 (human)[1]Band 1q23.2 Start 159,712,289 bp[1]End 159,714,589 bp[1]Gene location (Mouse)Chr. Chromosome
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Digital Object Identifier
In computing, a Digital Object Identifier or DOI is a persistent identifier or handle used to uniquely identify objects, standardized by the International Organization for Standardization
International Organization for Standardization
(ISO).[1] An implementation of the Handle System,[2][3] DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos. A DOI aims to be "resolvable", usually to some form of access to the information object to which the DOI refers. This is achieved by binding the DOI to metadata about the object, such as a URL, indicating where the object can be found. Thus, by being actionable and interoperable, a DOI differs from identifiers such as ISBNs and ISRCs which aim only to uniquely identify their referents
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International Standard Serial Number
An International Standard Serial Number
International Standard Serial Number
(ISSN) is an eight-digit serial number used to uniquely identify a serial publication.[1] The ISSN is especially helpful in distinguishing between serials with the same title. ISSN are used in ordering, cataloging, interlibrary loans, and other practices in connection with serial literature.[2] The ISSN system was first drafted as an International Organization for Standardization (ISO) international standard in 1971 and published as ISO 3297 in 1975.[3] ISO subcommittee TC 46/SC 9 is responsible for maintaining the standard. When a serial with the same content is published in more than one media type, a different ISSN is assigned to each media type. For example, many serials are published both in print and electronic media
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International Standard Book Number
"ISBN" redirects here. For other uses, see ISBN (other).International Standard Book
Book
NumberA 13-digit ISBN, 978-3-16-148410-0, as represented by an EAN-13 bar codeAcronym ISBNIntroduced 1970; 48 years ago (1970)Managing organisation International ISBN AgencyNo. of digits 13 (formerly 10)Check digit Weighted sumExample 978-3-16-148410-0Website www.isbn-international.orgThe International Standard Book
Book
Number (ISBN) is a unique[a][b] numeric commercial book identifier. Publishers purchase ISBNs from an affiliate of the International ISBN Agency.[1] An ISBN is assigned to each edition and variation (except reprintings) of a book. For example, an e-book, a paperback and a hardcover edition of the same book would each have a different ISBN. The ISBN is 13 digits long if assigned on or after 1 January 2007, and 10 digits long if assigned before 2007
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Special
Special
Special
or specials may refer to:Contents1 Music 2 Film and television 3 Other uses 4 See alsoMusic[edit] Special
Special
(album), a 1992 album by Vesta Williams "Special" (Garbage song), 1998 "Special
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OCLC
OCLC, currently incorporated as OCLC
OCLC
Online Computer Library Center, Incorporated,[3] is an American nonprofit cooperative organization "dedicated to the public purposes of furthering access to the world's information and reducing information costs".[4] It was founded in 1967 as the Ohio College Library Center. OCLC
OCLC
and its member libraries cooperatively produce and maintain WorldCat, the largest online public access catalog (OPAC) in the world
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PubMed Identifier
PubMed
PubMed
is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine
United States National Library of Medicine
(NLM) at the National Institutes of Health
National Institutes of Health
maintains the database as part of the Entrez
Entrez
system of information retrieval. From 1971 to 1997, MEDLINE online access to the MEDLARS Online computerized database primarily had been through institutional facilities, such as university libraries
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Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is an extremely rare type of psoriasis that can present in a variety of forms. Unlike the most general and common forms of psoriasis, GPP usually covers the entire body and with pus-filled blisters rather than plaques. GPP can present at any age, but is rarer in young children. It can appear with or without previous psoriasis conditions or history, and can reoccur in periodic episodes.Contents1 Signs and Symptoms 2 Severity 3 Classification3.1 von Zumbusch acute generalized pustular psoriasis 3.2 Generalized pustular psoriasis of pregnancy (Impetigo herpetiformis) 3.3 Infantile and juvenile 3.4 Circinate and annular4 Causes 5 Genetic Factors 6 Treatments 7 Case Reports7.1 Case Report 1 7.2 Case Report 2 7.3 Case Report 3 7.4 Case Report 4 7.5 Case Report 58 See also 9 ReferencesSigns and Symptoms[edit] GPP presents as pustules and plaques over a wide area of the body
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(von Zumbusch) Acute Generalized Pustular Psoriasis
von Zumbusch (acute) generalized pustular psoriasis, (acute GPP) is the most severe form of generalized pustular psoriasis, and can be associated with life-threatening complications.[1]Contents1 Signs and symptoms 2 Diagnosis 3 Treatment 4 History 5 ReferencesSigns and symptoms[edit] Patients with acute GPP experience the eruption of multiple isolated sterile pustules generalized over the body, recurrent fevers, fatigue, and laboratory abnormalities (elevated ESR, elevated CRP, combined with leukocytosis).[2] Diagnosis[edit] Kogoj's spongiform pustules can be observed via histopathology to confirm acute GPP.[2] Treatment[edit] Acute GPP typically requires inpatient management including both topical and systemic therapy, and supportive measures.[3] Systemic glucocorticoid withdrawal is a common causative agent.[4] Withdrawal or administration of certain drugs in the patient's previous medication regimen may be required
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