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Uroscopy is the historical medical practice of visually examining a patient's
urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excreted from the body through the urethra. Cellular m ...
for
pus Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during bacterial or fungal infection. An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collection ...
,
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in th ...
, or other symptoms of disease. The first records of uroscopy as a method for determining symptoms of an illness date back to the
4th millennium BC The 4th millennium BC spanned the years 4000 BC to 3001 BC. Some of the major changes in human culture during this time included the beginning of the Bronze Age and the invention of writing, which played a major role in starting recorded histor ...
, and became common practice in
Classical Greece Classical Greece was a period of around 200 years (the 5th and 4th centuries BC) in Ancient Greece,The "Classical Age" is "the modern designation of the period from about 500 B.C. to the death of Alexander the Great in 323 B.C." ( Thomas R. Marti ...
. Later reaching medical predominance during the
Byzantine Era The Byzantine calendar, also called the Roman calendar, the Creation Era of Constantinople or the Era of the World ( grc, Ἔτη Γενέσεως Κόσμου κατὰ Ῥωμαίους, also or , abbreviated as ε.Κ.; literal translation of ...
&
High Middle Ages The High Middle Ages, or High Medieval Period, was the period of European history that lasted from AD 1000 to 1300. The High Middle Ages were preceded by the Early Middle Ages and were followed by the Late Middle Ages, which ended around AD 1500 ...
, the practice eventually was replaced with more accurate methods during the early modern period, with uroscopy being considered inadequate due to the lack of
empirical evidence Empirical evidence for a proposition is evidence, i.e. what supports or counters this proposition, that is constituted by or accessible to sense experience or experimental procedure. Empirical evidence is of central importance to the sciences and ...
and higher standards of post-
Renaissance The Renaissance ( , ) , from , with the same meanings. is a period in European history marking the transition from the Middle Ages to modernity and covering the 15th and 16th centuries, characterized by an effort to revive and surpass ide ...
medicine. In modern medicine, visual examination of a patient's urine may provide preliminary evidence for a diagnosis, but is generally limited to conditions that specifically affect the
urinary system The urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, co ...
such as urinary tract infections,
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blo ...
and
bladder The urinary bladder, or simply bladder, is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination. In humans the bladder is a distensible organ that sits on the pelvic floor. Urine enters ...
issues, and
liver The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it ...
failure.


History

Records of urinalysis for uroscopy date back as far as 4000 BC, originating with Babylonian and Sumerian physicians. At the outset of the 4th century BC Greek physician
Hippocrates Hippocrates of Kos (; grc-gre, Ἱπποκράτης ὁ Κῷος, Hippokrátēs ho Kôios; ), also known as Hippocrates II, was a Greek physician of the classical period who is considered one of the most outstanding figures in the history ...
hypothesized that urine was a "filtrate" of the
four humors Humorism, the humoral theory, or humoralism, was a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek and Roman physicians and philosophers. Humorism began to fall out of favor in the 1850s ...
, and limited possible the diagnoses resulting from this method to issues dealing with the
bladder The urinary bladder, or simply bladder, is a hollow organ in humans and other vertebrates that stores urine from the kidneys before disposal by urination. In humans the bladder is a distensible organ that sits on the pelvic floor. Urine enters ...
,
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blo ...
s, and
urethra The urethra (from Greek οὐρήθρα – ''ourḗthrā'') is a tube that connects the urinary bladder to the urinary meatus for the removal of urine from the body of both females and males. In human females and other primates, the urethra con ...
. This in turn led another Greek physician,
Galen Aelius Galenus or Claudius Galenus ( el, Κλαύδιος Γαληνός; September 129 – c. AD 216), often Anglicized as Galen () or Galen of Pergamon, was a Greek physician, surgeon and philosopher in the Roman Empire. Considered to be one o ...
, to refine the idea down to urine being a filtrate of only blood, and not of black bile,
yellow bile Humorism, the humoral theory, or humoralism, was a system of medicine detailing a supposed makeup and workings of the human body, adopted by Ancient Greek and Roman physicians and philosophers. Humorism began to fall out of favor in the 1850s ...
, or
phlegm Phlegm (; , ''phlégma'', "inflammation", "humour caused by heat") is mucus produced by the respiratory system, excluding that produced by the nasal passages. It often refers to respiratory mucus expelled by coughing, otherwise known as sputum. ...
. Byzantine medicine followed, though it maintained its roots from Greco-Roman antiquity, and continued the application and study of uroscopy – it eventually becoming the primary form of ailment diagnosis. Byzantine physicians created some of the foundational codifications of uroscopy, with the most well known example being a 7th-century guide on uroscopic methods:
Theophilus Protospatharius Theophilus Protospatharius ( el, Θεόφιλος Πρωτοσπαθάριος; ca. 7th century) was the author of several extant Greek medical works of uncertain status, either from Philaretus or Philotheus. Nothing is known of his life or the ti ...
's ''On Urines''. The work, along with others, became widely popular and accelerated the rate at which uroscopy spread throughout the Mediterranean. Over time these Byzantine works inspired further interpretation by other prominent culture's scholars (like the Arab Jewish
Isaac Israeli ben Solomon Isaac Israeli ben Solomon (Hebrew: יצחק בן שלמה הישראלי, ''Yitzhak ben Shlomo ha-Yisraeli''; Arabic: أبو يعقوب إسحاق بن سليمان الإسرائيلي, ''Abu Ya'qub Ishaq ibn Suleiman al-Isra'ili'') ( 832 &ndas ...
and his urine-hue classification chart), though greater propagation led to a widened application of uroscopy and eventually uroscopic diagnoses of non-urinary related diseases and infections became standard. Pivotal in the spread of uroscopy,
Constantine the African Constantine the African ( la, Constantinus Africanus; died before 1098/1099, Monte Cassino) was a physician who lived in the 11th century. The first part of his life was spent in Ifriqiya and the rest in Italy. He first arrived in Italy in the ...
's Latin translations of Byzantine and Arab texts inspired a new era in uroscopic interest specifically in
western Europe Western Europe is the western region of Europe. The region's countries and territories vary depending on context. The concept of "the West" appeared in Europe in juxtaposition to "the East" and originally applied to the ancient Mediterranean ...
throughout the High Middle Ages. Despite this popularization, uroscopy was still mostly maintained by the principals Hippocrates's and Galen's first postulated, aided by Byzantine interpretations that were further disseminated during this period in works by French physicians of the era Bernard de Gordon and
Gilles de Corbeil Gilles de Corbeil ( Latin: ''Egidius de Corbolio'' or ''Egidius Corboliensis''; also ''Aegidius'') was a French royal physician, teacher, and poet. He was born in approximately 1140 in Corbeil and died in the first quarter of the 13th century. H ...
. The practice was upheld as the standard until the beginning of the 16th century when influence from cultural movements like the
Renaissance The Renaissance ( , ) , from , with the same meanings. is a period in European history marking the transition from the Middle Ages to modernity and covering the 15th and 16th centuries, characterized by an effort to revive and surpass ide ...
inspired the re-examination of its methods, both to re-evaluate its effectiveness and explore new applications. During this period, a lack of empirical evidence supporting uroscopy and the introduction of new medical practices developed using the
scientific method The scientific method is an empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article history of scientific me ...
contributed to its gradual decline among licensed physicians. Early modern doctors, like the
Swiss Swiss may refer to: * the adjectival form of Switzerland * Swiss people Places * Swiss, Missouri * Swiss, North Carolina * Swiss, West Virginia *Swiss, Wisconsin Other uses * Swiss-system tournament, in various games and sports *Swiss Internatio ...
medical pioneer
Paracelsus Paracelsus (; ; 1493 – 24 September 1541), born Theophrastus von Hohenheim (full name Philippus Aureolus Theophrastus Bombastus von Hohenheim), was a Swiss physician, alchemist, lay theologian, and philosopher of the German Renaissance. H ...
, began researching more empirically qualified approaches to diagnosis and treatment – an integral part of the Medical Renaissance and its redefining how we look at medicine —which only further hastened the decline of uroscopy. Since the beginning of the 17th century the practice has been largely considered unverifiable and unorthodox, and became a subject of satire (including multiple satirical references in the plays of
Shakespeare William Shakespeare ( 26 April 1564 – 23 April 1616) was an English playwright, poet and actor. He is widely regarded as the greatest writer in the English language and the world's pre-eminent dramatist. He is often called England's natio ...
). It was still practiced by "unlicensed practitioners" by popular demand up until around the beginning of the 19th century. Though uroscopy is no longer popular in modern medicine, examples of its preliminary diagnostic utility still exist in simplified and empirically proven forms. Incidentally, as the decline of uroscopy continued a new form of
divination Divination (from Latin ''divinare'', 'to foresee, to foretell, to predict, to prophesy') is the attempt to gain insight into a question or situation by way of an occultic, standardized process or ritual. Used in various forms throughout history ...
emerged from its remnants in "Uromancy" – the analysis of one's urine for fortune-telling or state-reading purposes. Although uromancy initially gained interest in the 18th and 19th centuries, it is rarely practiced and unknown to most in the present era.


Procedures and conventions

Practitioners of uroscopy are referred to as uroscopists. In the era in which uroscopy was a popular way of thinking, one of the major benefits was the lack of
surgical operation Surgery ''cheirourgikē'' (composed of χείρ, "hand", and ἔργον, "work"), via la, chirurgiae, meaning "hand work". is a medical specialty that uses operative manual and instrumental techniques on a person to investigate or treat a pa ...
s, lending itself to the most conservative of adherents to the
Hippocratic Oath The Hippocratic Oath is an oath of ethics historically taken by physicians. It is one of the most widely known of Greek medical texts. In its original form, it requires a new physician to swear, by a number of healing gods, to uphold specific e ...
.


Matula (flask)

A uroscopy flask, also known as a "matula", is a piece of transparent glass – this is imperative as colorations, along with any deformations, in the glass may lead to a misdiagnosis – that is circular at the bottom, while there is a thin neck at the top, and an opening for the patient to urinate in.


Urine wheel

The uroscopy wheel is a diagram that linked the color of urine to a particular disease. It usually has twenty different uroscopy flasks with urine of different colors aligned around the border of the circle. Each flask has a line that connects it to a summary of a particular disease. This allowed doctors to have a quick reference guide to twenty different types of urine.


Temperature

The temperature at which the urine is examined is a very important factor to consider in the process of uroscopy. When a patient urinates, the urine will be warm, so it is necessary for it to stay warm for proper evaluation. The external temperature should be the same as the internal temperature. When the temperature of urine goes down the bubbles in it will change. Some of them will disappear, but some will remain. With the temperature decrease, particles and impurities will be more difficult to evaluate. They will move toward the middle of the flask, then sink to the bottom. They will all mix, making it more difficult to see the impurities. Another problem with urine cooling is that it would become thicker. The longer that it had to cool down the more likely it was that the crystals in it would bond together, causing it to thicken. This could lead to a false diagnosis, that is why doctors usually inspected the urine quickly. Richard Bright in the 19th century invented a technique that allowed doctors to examine a patients urine effectively after the temperature had dropped. The process involved heating water, then inserting the uroscopy flask containing cooled urine. This would heat the urine causing the crystals that formed during loss of temperature to break down. As a result, the urine will become thin again. This process is very effective, but a doctor should "also be careful not to shake them much before you inspect them for you will move the particles and destroy the bubbles and dilute the deposits and confuse the situation," (The Late
Greco-Roman The Greco-Roman civilization (; also Greco-Roman culture; spelled Graeco-Roman in the Commonwealth), as understood by modern scholars and writers, includes the geographical regions and countries that culturally—and so historically—were dir ...
and Byzantine Contribution to the Evolution of Laboratory Examinations of Bodily Excrement. Part1: Urine, Sperm, Menses and Stools, Pavlos C. Goudas).


Lighting

Since identifying the color of the urine is essential for a proper diagnosis, the lighting is crucial. This is a very complicated step in the uroscopy test. The doctor must not visually examine the urine in an overly lit location, because it will make the urine seem too bright. He can not examine the urine in a poorly lit location, because he will not be able to properly see the urine. So, he must examine the urine in both conditions. This is done to offset the effects of not enough light and too much light. After he examines both conditions the doctor must use his best judgment, to make a diagnosis.


Common diseases identified by uroscopic methods


Diabetes

In 1674 English doctor
Thomas Willis Thomas Willis FRS (27 January 1621 – 11 November 1675) was an English doctor who played an important part in the history of anatomy, neurology and psychiatry, and was a founding member of the Royal Society. Life Willis was born on his pare ...
submitted into medical literature a peculiar (and peculiarly found) relationship he'd observed: people with
type 1 diabetes Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that originates when cells that make insulin (beta cells) are destroyed by the immune system. Insulin is a hormone required for the cells to use blood sugar fo ...
usually have sweet-tasting urine — this is due to an oversaturation of
glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, u ...
in the blood, the excess of which is excreted out via urine, as the diabetic lacks sufficient insulin to process the high amounts of glucose.


Jaundice

Yellowish discoloration of the whites of the eyes, skin, and
mucous membrane A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is ...
s caused by deposition of
bilirubin Bilirubin (BR) (Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from t ...
in these tissues. It occurs as a symptom of various diseases, such as hepatitis, that affect the processing of bile. Also called Icterus. Doctors would test by using their vision. If the urine had a brownish tint then the patient would most likely have jaundice.


Kidney disease

The kidneys are supposed to filter excesses (especially urea) from the blood and excrete them, along with water, as urine. When they are not performing this task the patient has a
kidney disease Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can b ...
. The medical field that studies the kidneys and diseases affecting the kidney is called nephrology, from the Ancient Greek name for kidney. Doctors would test urine using a visual examination. If the urine was red or foamy, the patient had kidney disease.


See also

*
Urinalysis Urinalysis, a portmanteau of the words ''urine'' and ''analysis'', is a panel of medical tests that includes physical (macroscopic) examination of the urine, chemical evaluation using urine test strips, and microscopic examination. Macroscopic ...
*
Urology Urology (from Greek οὖρον ''ouron'' "urine" and ''-logia'' "study of"), also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of the urinary-tract system and the reproductive orga ...


References

*


External links


Library of Congress: Exploring Uroscopy in Early Medical Texts
{{Authority control Nephrology Urine tests Physical examination Urine History of medicine