The spiroindolones are a class of compounds in which an indolone ring is substituted with another ring in a spiro arrangement.

Alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

s in this class include horsfiline,

rhynchophylline Rhynchophylline is an alkaloid found in certain ''Uncaria'' species (Rubiaceae), notably '' Uncaria rhynchophylla'' and '' Uncaria tomentosa''. It also occurs in the leaves of ''Mitragyna speciosa'' (kratom), a tree native to Thailand. Chemicall ...

gelsemine Gelsemine (C20H22N2O2) is an indole alkaloid isolated from flowering plants of the genus ''Gelsemium'', a plant native to the subtropical and tropical Americas, and southeast Asia, and is a highly toxic compound that acts as a paralytic, exposu ...

, carapanaubine, and maremycin E. Spiroindolones are also an emerging class of

antimalarial drug Antimalarial medications or simply antimalarials are a type of antiparasitic chemical agent, often naturally derived, that can be used to treat or to prevent malaria, in the latter case, most often aiming at two susceptible target groups, young c ...

s whose mode of action is to inhibit protein synthesis in the target parasite. The most advanced compound in this class in terms of

drug development Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for re ...

is cipargamin (NITD609).

References

Antimalarial agents Spiro compounds {{antiinfective-drug-stub