Procollagen peptidase (, ''procollagen
N-terminal peptidase'', ''procollagen aminopeptidase'', ''aminoprocollagen peptidase'', ''aminoterminal procollagen peptidase'', ''procollagen aminoterminal protease'', ''procollagen N-terminal proteinase'', ''type I/II procollagen N-proteinase'', ''type III procollagen'') is an
endopeptidase
Endopeptidase or endoproteinase are proteolytic peptidases that break peptide bonds of nonterminal amino acids (i.e. within the molecule), in contrast to exopeptidases, which break peptide bonds from end-pieces of terminal amino acids. For this ...
involved in the processing of
collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to
dermatosparaxis or
Ehlers–Danlos syndrome.
The enzyme is present in the skin of rats and humans.
References
External links
* The
MEROPS
MEROPS is an online database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors. The classification scheme for peptidases was published by Rawlings & Barrett in 1993, and that for protein inhibit ...
online database for peptidases and their inhibitors: Procollagen C-Peptidas
M12.005 Procollagen N-Peptidas
M12.301
External links
*
Proteases
EC 3.4.24
{{hydrolase-stub