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* Nanomaterials describe, in principle,
material Material is a substance or mixture of substances that constitutes an object. Materials can be pure or impure, living or non-living matter. Materials can be classified on the basis of their physical and chemical properties, or on their geolo ...
s of which a single unit is sized (in at least one dimension) between 1 and 100 nm (the usual definition of nanoscale). Nanomaterials research takes a materials science-based approach to nanotechnology, leveraging advances in materials metrology and synthesis which have been developed in support of
microfabrication Microfabrication is the process of fabricating miniature structures of micrometre scales and smaller. Historically, the earliest microfabrication processes were used for integrated circuit fabrication, also known as " semiconductor manufacturing ...
research. Materials with structure at the nanoscale often have unique optical, electronic, thermo-physical or mechanical properties. Nanomaterials are slowly becoming commercialized and beginning to emerge as commodities.


Definition

In
ISO/TS 80004 The ISO/TS 80004 series of standards, from the International Organization for Standardization, describe vocabulary for nanotechnology and its applications. These were largely motivated by health, safety and environment concerns, many of them origina ...
, ''nanomaterial'' is defined as the "material with any external dimension in the nanoscale or having internal structure or surface structure in the nanoscale", with ''nanoscale'' defined as the "length range approximately from 1 nm to 100 nm". This includes both ''nano-objects'', which are discrete pieces of material, and ''nanostructured materials'', which have internal or surface structure on the nanoscale; a nanomaterial may be a member of both these categories. On 18 October 2011, the
European Commission The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body ...
adopted the following definition of a nanomaterial: "A natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm – 100 nm. In specific cases and where warranted by concerns for the environment, health, safety or competitiveness the number size distribution threshold of 50% may be replaced by a threshold between 1% to 50%."


Sources


Engineered

Engineered nanomaterials have been deliberately engineered and manufactured by humans to have certain required properties. Legacy nanomaterials are those that were in commercial production prior to the development of nanotechnology as incremental advancements over other colloidal or particulate materials. They include carbon black and titanium dioxide nanoparticles.


Incidental

Nanomaterials may be unintentionally produced as a byproduct of mechanical or industrial processes through combustion and vaporization. Sources of incidental nanoparticles include vehicle engine exhausts, smelting, welding fumes, combustion processes from domestic solid fuel heating and cooking. For instance, the class of nanomaterials called fullerenes are generated by burning gas, biomass, and candle. It can also be a byproduct of wear and corrosion products. Incidental atmospheric nanoparticles are often referred to as ultrafine particles, which are unintentionally produced during an intentional operation, and could contribute to
air pollution Air pollution is the contamination of air due to the presence of substances in the atmosphere that are harmful to the health of humans and other living beings, or cause damage to the climate or to materials. There are many different type ...
.


Natural

Biological systems often feature natural, functional nanomaterials. The structure of foraminifera (mainly chalk) and viruses (protein, capsid), the wax crystals covering a lotus or nasturtium leaf, spider and spider-mite silk, the blue hue of tarantulas, the "spatulae" on the bottom of gecko feet, some butterfly wing scales, natural colloids (
milk Milk is a white liquid food produced by the mammary glands of mammals. It is the primary source of nutrition for young mammals (including breastfed human infants) before they are able to digest solid food. Immune factors and immune-modulat ...
,
blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the cir ...
), horny materials ( skin, claws, beaks, feathers, horns, hair),
paper Paper is a thin sheet material produced by mechanically or chemically processing cellulose fibres derived from wood, rags, grasses or other vegetable sources in water, draining the water through fine mesh leaving the fibre evenly distribu ...
,
cotton Cotton is a soft, fluffy staple fiber that grows in a boll, or protective case, around the seeds of the cotton plants of the genus '' Gossypium'' in the mallow family Malvaceae. The fiber is almost pure cellulose, and can contain minor pe ...
, nacre, corals, and even our own
bone A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, ...
matrix are all natural ''organic'' nanomaterials. Natural ''inorganic'' nanomaterials occur through crystal growth in the diverse chemical conditions of the Earth's crust. For example,
clay Clay is a type of fine-grained natural soil material containing clay minerals (hydrous aluminium phyllosilicates, e.g. kaolin, Al2 Si2 O5( OH)4). Clays develop plasticity when wet, due to a molecular film of water surrounding the clay pa ...
s display complex nanostructures due to anisotropy of their underlying crystal structure, and volcanic activity can give rise to opals, which are an instance of a naturally occurring photonic crystals due to their nanoscale structure. Fires represent particularly complex reactions and can produce pigments, cement,
fumed silica Fumed silica (CAS_Registry_Number, CAS number 112945-52-5), also known as pyrogenic silica because it is produced in a flame, consists of microscopic droplets of amorphous silica fused into branched, chainlike, three-dimensional secondary partic ...
etc. Natural sources of nanoparticles include combustion products forest fires, volcanic ash, ocean spray, and the radioactive decay of
radon Radon is a chemical element with the symbol Rn and atomic number 86. It is a radioactive, colourless, odourless, tasteless noble gas. It occurs naturally in minute quantities as an intermediate step in the normal radioactive decay chains th ...
gas. Natural nanomaterials can also be formed through weathering processes of metal- or anion-containing rocks, as well as at acid mine drainage sites. ;Gallery of natural nanomaterials File:Kapsid Schema-01.png, Viral capsid File:Lotoseffekt.jpg, " Lotus effect", hydrophobic effect with self-cleaning ability File:Gecko foot on glass.JPG, Close-up of the underside of a gecko's foot as it walks on a glass wall (spatula: 200 × 10-15 nm) File:SEM image of a Peacock wing, slant view 4.JPG, SEM micrograph of a butterfly wing scale (× 5000) File:Trevarno, pavo cristatus06.jpg, Peacock feather (detail) File:62cts Brazilian Crystal Opal.JPG, Brazilian Crystal Opal. The play of color is caused by the interference and diffraction of light between silica spheres (150 - 300 nm in diameter). File:Lasiodora parahybana, claws.JPG, Blue hue of a species of tarantula (450 nm ± 20 nm)


Types

Nano-objects are often categorized as to how many of their dimensions fall in the nanoscale. A '' nanoparticle'' is defined a nano-object with all three external dimensions in the nanoscale, whose longest and the shortest axes do not differ significantly. A '' nanofiber'' has two external dimensions in the nanoscale, with ''nanotubes'' being hollow nanofibers and ''nanorods'' being solid nanofibers. A ''nanoplate/nanosheet'' has one external dimension in the nanoscale, and if the two larger dimensions are significantly different it is called a ''
nanoribbon Nanoribbon may refer to: * Graphene nanoribbons * Silicene nanoribbons * Boron nitride nanoribbons * Gallium(III) oxide nanoribbons * titanate nanoribbons - see titanium dioxide * Phosphorene Phosphorene is a two-dimensional material consist ...
''. For nanofibers and nanoplates, the other dimensions may or may not be in the nanoscale, but must be significantly larger. In all of these cases, a significant difference is noted to typically be at least a factor of 3. Nanostructured materials are often categorized by what phases of matter they contain. A ''
nanocomposite Nanocomposite is a multiphase solid material where one of the phases has one, two or three dimensions of less than 100 nanometers (nm) or structures having nano-scale repeat distances between the different phases that make up the material. The id ...
'' is a solid containing at least one physically or chemically distinct region or collection of regions, having at least one dimension in the nanoscale. A ''
nanofoam Nanofoams are a class of nanostructured, porous materials (foams) containing a significant population of pores with diameters less than 100 nm. Aerogels are one example of nanofoam. Metal Overview Metallic nanofoams are a subcategorization ...
'' has a liquid or solid matrix, filled with a gaseous phase, where one of the two phases has dimensions on the nanoscale. A ''nanoporous material'' is a solid material containing
nanopore A nanopore is a pore of nanometer size. It may, for example, be created by a pore-forming protein or as a hole in synthetic materials such as silicon or graphene. When a nanopore is present in an electrically insulating membrane, it can be used ...
s, voids in the form of open or closed pores of sub-micron lengthscales. A ''
nanocrystalline material A nanocrystalline (NC) material is a polycrystalline material with a crystallite size of only a few nanometers. These materials fill the gap between amorphous materials without any long range order and conventional coarse-grained materials. Defi ...
'' has a significant fraction of crystal grains in the nanoscale.


Nanoporous materials

The term ''nanoporous materials'' contain subsets of microporous and mesoporous materials. Microporous materials are porous materials with a mean pore size smaller than 2 nm, while mesoporous materials are those with pores sizes in the region 2-50 nm. Microporous materials exhibit pore sizes with comparable length-scale to small molecules. For this reason such materials may serve valuable applications including separation membranes. Mesoporous materials are interesting towards applications that require high specific surface areas, while enabling penetration for molecules that may be too large to enter the pores of a microporous material. In some sources, nanoporous materials and nanofoam are sometimes considered nanostructures but not nanomaterials because only the voids and not the materials themselves are nanoscale. Although the ISO definition only considers round nano-objects to be nanoparticles, other sources use the term nanoparticle for all shapes.


Nanoparticles

Nanoparticles have all three dimensions on the nanoscale. Nanoparticles can also be embedded in a bulk solid to form a nanocomposite.


Fullerenes

The fullerenes are a class of
allotropes of carbon Carbon is capable of forming many allotropes (structurally different forms of the same element) due to its valency. Well-known forms of carbon include diamond and graphite. In recent decades, many more allotropes have been discovered and rese ...
which conceptually are
graphene Graphene () is an allotrope of carbon consisting of a Single-layer materials, single layer of atoms arranged in a hexagonal lattice nanostructure.
sheets rolled into tubes or spheres. These include the carbon nanotubes (or silicon nanotubes) which are of interest both because of their mechanical strength and also because of their electrical properties. The first fullerene molecule to be discovered, and the family's namesake, buckminsterfullerene (C60), was prepared in 1985 by Richard Smalley, Robert Curl,
James Heath James Heath may refer to: * James Heath (historian) (1629–1664), English royalist historian * James Heath (engraver) (1757–1834), English engraver * James P. Heath (1777–1854), U.S. congressman from Maryland * James E. Heath (active since 1 ...
, Sean O'Brien, and Harold Kroto at Rice University. The name was a homage to
Buckminster Fuller Richard Buckminster Fuller (; July 12, 1895 – July 1, 1983) was an American architect, systems theorist, writer, designer, inventor, philosopher, and futurist. He styled his name as R. Buckminster Fuller in his writings, publishing ...
, whose geodesic domes it resembles. Fullerenes have since been found to occur in nature. More recently, fullerenes have been detected in outer space. For the past decade, the chemical and physical properties of fullerenes have been a hot topic in the field of research and development, and are likely to continue to be for a long time. In April 2003, fullerenes were under study for potential medicinal use: binding specific antibiotics to the structure of resistant bacteria and even target certain types of
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
cells such as melanoma. The October 2005 issue of Chemistry and Biology contains an article describing the use of fullerenes as light-activated antimicrobial agents. In the field of nanotechnology, heat resistance and superconductivity are among the properties attracting intense research. A common method used to produce fullerenes is to send a large current between two nearby graphite electrodes in an inert atmosphere. The resulting
carbon Carbon () is a chemical element with the symbol C and atomic number 6. It is nonmetallic and tetravalent—its atom making four electrons available to form covalent chemical bonds. It belongs to group 14 of the periodic table. Carbon ma ...
plasma arc between the electrodes cools into sooty residue from which many fullerenes can be isolated. There are many calculations that have been done using ab-initio Quantum Methods applied to fullerenes. By DFT and TDDFT methods one can obtain IR, Raman and UV spectra. Results of such calculations can be compared with experimental results.


Metal-based nanoparticles

Inorganic nanomaterials, (e.g. quantum dots, nanowires and nanorods) because of their interesting optical and electrical properties, could be used in optoelectronics. Furthermore, the optical and electronic properties of nanomaterials which depend on their size and shape can be tuned via synthetic techniques. There are the possibilities to use those materials in organic material based optoelectronic devices such as
Organic solar cells An organic solar cell (OSC) or plastic solar cell is a type of photovoltaic that uses organic electronics, a branch of electronics that deals with conductive organic polymers or small organic molecules, for light absorption and charge transport t ...
, OLEDs etc. The operating principles of such devices are governed by photoinduced processes like electron transfer and energy transfer. The performance of the devices depends on the efficiency of the photoinduced process responsible for their functioning. Therefore, better understanding of those photoinduced processes in organic/inorganic nanomaterial composite systems is necessary in order to use them in optoelectronic devices. Nanoparticles or nanocrystals made of metals, semiconductors, or oxides are of particular interest for their mechanical, electrical, magnetic, optical, chemical and other properties. Nanoparticles have been used as quantum dots and as chemical catalysts such as
nanomaterial-based catalyst Nanomaterial-based catalysts are usually heterogeneous catalysts broken up into metal nanoparticles in order to enhance the catalytic process. Metal nanoparticles have high surface area, which can increase catalytic activity. Nanoparticle catalysts ...
s. Recently, a range of nanoparticles are extensively investigated for biomedical applications including tissue engineering, drug delivery, biosensor. Nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and
atom Every atom is composed of a nucleus and one or more electrons bound to the nucleus. The nucleus is made of one or more protons and a number of neutrons. Only the most common variety of hydrogen has no neutrons. Every solid, liquid, gas, a ...
ic or molecular structures. A bulk material should have constant physical properties regardless of its size, but at the nano-scale this is often not the case. Size-dependent properties are observed such as
quantum confinement A potential well is the region surrounding a local minimum of potential energy. Energy captured in a potential well is unable to convert to another type of energy ( kinetic energy in the case of a gravitational potential well) because it is ca ...
in semiconductor particles, surface plasmon resonance in some metal particles and
superparamagnetism Superparamagnetism is a form of magnetism which appears in small ferromagnetic or ferrimagnetic nanoparticles. In sufficiently small nanoparticles, magnetization can randomly flip direction under the influence of temperature. The typical time be ...
in magnetic materials. Nanoparticles exhibit a number of special properties relative to bulk material. For example, the bending of bulk
copper Copper is a chemical element with the symbol Cu (from la, cuprum) and atomic number 29. It is a soft, malleable, and ductile metal with very high thermal and electrical conductivity. A freshly exposed surface of pure copper has a pink ...
(wire, ribbon, etc.) occurs with movement of copper atoms/clusters at about the 50 nm scale. Copper nanoparticles smaller than 50 nm are considered super hard materials that do not exhibit the same malleability and ductility as bulk copper. The change in properties is not always desirable. Ferroelectric materials smaller than 10 nm can switch their polarization direction using room temperature thermal energy, thus making them useless for memory storage. Suspensions of nanoparticles are possible because the interaction of the particle surface with the solvent is strong enough to overcome differences in
density Density (volumetric mass density or specific mass) is the substance's mass per unit of volume. The symbol most often used for density is ''ρ'' (the lower case Greek letter rho), although the Latin letter ''D'' can also be used. Mathematicall ...
, which usually result in a material either sinking or floating in a liquid. Nanoparticles often have unexpected visual properties because they are small enough to confine their electrons and produce quantum effects. For example, gold nanoparticles appear deep red to black in solution. The often very high surface area to volume ratio of nanoparticles provides a tremendous driving force for
diffusion Diffusion is the net movement of anything (for example, atoms, ions, molecules, energy) generally from a region of higher concentration to a region of lower concentration. Diffusion is driven by a gradient in Gibbs free energy or chemical ...
, especially at elevated temperatures. Sintering is possible at lower temperatures and over shorter durations than for larger particles. This theoretically does not affect the density of the final product, though flow difficulties and the tendency of nanoparticles to agglomerate do complicate matters. The surface effects of nanoparticles also reduces the incipient melting temperature.


One-dimensional nanostructures

The smallest possible crystalline wires with cross-section as small as a single atom can be engineered in cylindrical confinement. Carbon nanotubes, a natural semi-1D nanostructure, can be used as a template for synthesis. Confinement provides mechanical stabilization and prevents linear atomic chains from disintegration; other structures of 1D nanowires are predicted to be mechanically stable even upon isolation from the templates.


Two-dimensional nanostructures

2D materials In materials science, the term single-layer materials or 2D materials refers to crystalline solids consisting of a single layer of atoms. These materials are promising for some applications but remain the focus of research. Single-layer material ...
are crystalline materials consisting of a two-dimensional single layer of atoms. The most important representative
graphene Graphene () is an allotrope of carbon consisting of a Single-layer materials, single layer of atoms arranged in a hexagonal lattice nanostructure.
was discovered in 2004. Thin films with nanoscale thicknesses are considered nanostructures, but are sometimes not considered nanomaterials because they do not exist separately from the substrate.


Bulk nanostructured materials

Some bulk materials contain features on the nanoscale, including
nanocomposite Nanocomposite is a multiphase solid material where one of the phases has one, two or three dimensions of less than 100 nanometers (nm) or structures having nano-scale repeat distances between the different phases that make up the material. The id ...
s,
nanocrystalline material A nanocrystalline (NC) material is a polycrystalline material with a crystallite size of only a few nanometers. These materials fill the gap between amorphous materials without any long range order and conventional coarse-grained materials. Defi ...
s, nanostructured films, and nanotextured surfaces. Box-shaped graphene (BSG) nanostructure is an example of 3D nanomaterial. BSG nanostructure has appeared after mechanical cleavage of pyrolytic graphite. This nanostructure is a multilayer system of parallel hollow nanochannels located along the surface and having quadrangular cross-section. The thickness of the channel walls is approximately equal to 1 nm. The typical width of channel facets makes about 25 nm.


Applications

Nano materials are used in a variety of, manufacturing processes, products and healthcare including paints, filters, insulation and lubricant additives. In healthcare
Nanozymes An artificial enzyme is a synthetic organic molecule or ion that recreates one or more functions of an enzyme. It seeks to deliver catalysis at rates and selectivity observed in naturally occurring enzymes. History Enzyme catalysis of chemical r ...
are nanomaterials with enzyme-like characteristics. They are an emerging type of
artificial enzyme An artificial enzyme is a synthetic organic molecule or ion that recreates one or more functions of an enzyme. It seeks to deliver catalysis at rates and selectivity observed in naturally occurring enzymes. History Enzyme catalysis of chemical re ...
, which have been used for wide applications in such as biosensing, bioimaging, tumor diagnosis, antibiofouling and more. High quality filters may be produced using nanostructures, these filters are capable of removing particulate as small as a virus as seen in a water filter created by Seldon Technologies. Nanomaterials membrane bioreactor (NMs-MBR), the next generation of conventional MBR, are recently proposed for the advanced treatment of wastewater. In the air purification field, nano technology was used to combat the spread of MERS in Saudi Arabian hospitals in 2012. Nanomaterials are being used in modern and human-safe insulation technologies, in the past they were found in Asbestos-based insulation. As a lubricant additive, nano materials have the ability to reduce friction in moving parts. Worn and corroded parts can also be repaired with self-assembling anisotropic nanoparticles called TriboTEX. Nanomaterials have also been applied in a range of industries and consumer products. Mineral nanoparticles such as titanium-oxide have been used to improve UV protection in sunscreen. In the sports industry, lighter bats to have been produced with carbon nanotubes to improve performance. Another application is in the military, where mobile pigment nanoparticles have been used to create more effective camouflage. Nanomaterials can also be used in three-way-catalyst (TWC) applications. TWC converters have the advantage of controlling the emission of nitrogen oxides (NOx), which are precursors to acid rain and smog. In core-shell structure, nanomaterials form shell as the catalyst support to protect the noble metals such as palladium and rhodium. The primary function is that the supports can be used for carrying catalysts active components, making them highly dispersed, reducing the use of noble metals, enhancing catalysts activity, and improving the mechanical strength.


Synthesis

The goal of any synthetic method for nanomaterials is to yield a material that exhibits properties that are a result of their characteristic length scale being in the nanometer range (1 – 100 nm). Accordingly, the synthetic method should exhibit control of size in this range so that one property or another can be attained. Often the methods are divided into two main types, "bottom up" and "top down".


Bottom up methods

Bottom up methods involve the assembly of atoms or molecules into nanostructured arrays. In these methods the raw material sources can be in the form of gases, liquids or solids. The latter require some sort of disassembly prior to their incorporation onto a nanostructure. Bottom up methods generally fall into two categories: chaotic and controlled. Chaotic processes involve elevating the constituent atoms or molecules to a chaotic state and then suddenly changing the conditions so as to make that state unstable. Through the clever manipulation of any number of parameters, products form largely as a result of the insuring kinetics. The collapse from the chaotic state can be difficult or impossible to control and so ensemble statistics often govern the resulting size distribution and average size. Accordingly, nanoparticle formation is controlled through manipulation of the end state of the products. Examples of chaotic processes are laser ablation, exploding wire, arc, flame pyrolysis, combustion, and precipitation synthesis techniques. Controlled processes involve the controlled delivery of the constituent atoms or molecules to the site(s) of nanoparticle formation such that the nanoparticle can grow to a prescribed sizes in a controlled manner. Generally the state of the constituent atoms or molecules are never far from that needed for nanoparticle formation. Accordingly, nanoparticle formation is controlled through the control of the state of the reactants. Examples of controlled processes are self-limiting growth solution, self-limited chemical vapor deposition, shaped pulse femtosecond laser techniques, and
molecular beam epitaxy Molecular-beam epitaxy (MBE) is an epitaxy method for thin-film deposition of single crystals. MBE is widely used in the manufacture of semiconductor devices, including transistors, and it is considered one of the fundamental tools for the dev ...
.


Top down methods

Top down methods adopt some 'force' (e. g. mechanical force, laser) to break bulk materials into nanoparticles. A popular method involves mechanical break apart bulk materials into nanomaterials is 'ball milling'. Besides, nanoparticles can also be made by laser ablation which apply short pulse lasers (e. g. femtosecond laser) to ablate a target (solid).


Characterization

Novel effects can occur in materials when structures are formed with sizes comparable to any one of many possible
length scale In physics, length scale is a particular length or distance determined with the precision of at most a few orders of magnitude. The concept of length scale is particularly important because physical phenomena of different length scales cannot ...
s, such as the de Broglie wavelength of electrons, or the optical wavelengths of high energy photons. In these cases quantum mechanical effects can dominate material properties. One example is
quantum confinement A potential well is the region surrounding a local minimum of potential energy. Energy captured in a potential well is unable to convert to another type of energy ( kinetic energy in the case of a gravitational potential well) because it is ca ...
where the electronic properties of solids are altered with great reductions in particle size. The optical properties of nanoparticles, e.g.
fluorescence Fluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation. It is a form of luminescence. In most cases, the emitted light has a longer wavelength, and therefore a lower photon energy, tha ...
, also become a function of the particle diameter. This effect does not come into play by going from macrosocopic to micrometer dimensions, but becomes pronounced when the nanometer scale is reached. In addition to optical and electronic properties, the novel mechanical properties of many nanomaterials is the subject of
nanomechanics Nanomechanics is a branch of '' nanoscience'' studying fundamental ''mechanical'' (elastic, thermal and kinetic) properties of physical systems at the nanometer scale. Nanomechanics has emerged on the crossroads of biophysics, classical mechanics, ...
research. When added to a bulk material, nanoparticles can strongly influence the mechanical properties of the material, such as the stiffness or elasticity. For example, traditional
polymer A polymer (; Greek '' poly-'', "many" + '' -mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic a ...
s can be reinforced by nanoparticles (such as carbon nanotubes) resulting in novel materials which can be used as lightweight replacements for metals. Such
composite Composite or compositing may refer to: Materials * Composite material, a material that is made from several different substances ** Metal matrix composite, composed of metal and other parts ** Cermet, a composite of ceramic and metallic materials ...
materials may enable a weight reduction accompanied by an increase in stability and improved functionality. Finally, nanostructured materials with small particle size such as zeolites, and asbestos, are used as catalysts in a wide range of critical industrial chemical reactions. The further development of such catalysts can form the basis of more efficient, environmentally friendly chemical processes. The first observations and size measurements of nano-particles were made during the first decade of the 20th century. Zsigmondy made detailed studies of gold sols and other nanomaterials with sizes down to 10 nm and less. He published a book in 1914. He used an
ultramicroscope An ultramicroscope is a microscope with a system that lights the object in a way that allows viewing of tiny particles via light scattering, and not light reflection or absorption. When the diameter of a particle is below or near the wavelength ...
that employs a ''dark field'' method for seeing particles with sizes much less than
light Light or visible light is electromagnetic radiation that can be perceived by the human eye. Visible light is usually defined as having wavelengths in the range of 400–700 nanometres (nm), corresponding to frequencies of 750–420 t ...
wavelength. There are traditional techniques developed during the 20th century in interface and colloid science for characterizing nanomaterials. These are widely used for ''first generation'' passive nanomaterials specified in the next section. These methods include several different techniques for characterizing particle size distribution. This characterization is imperative because many materials that are expected to be nano-sized are actually aggregated in solutions. Some of methods are based on light scattering. Others apply ultrasound, such as ultrasound attenuation spectroscopy for testing concentrated nano-dispersions and microemulsions. There is also a group of traditional techniques for characterizing surface charge or zeta potential of nano-particles in solutions. This information is required for proper system stabilization, preventing its aggregation or flocculation. These methods include microelectrophoresis, electrophoretic light scattering and electroacoustics. The last one, for instance
colloid vibration current Colloid vibration current is an electroacoustic phenomenon that arises when ultrasound propagates through a fluid that contains ions and either solid particles or emulsion droplets. Dukhin, A.S. and Goetz, P.J"Characterization of liquids, nano- an ...
method is suitable for characterizing concentrated systems.


Mechanical Properties

The ongoing research has shown that mechanical properties can vary significantly in nanomaterials compared to bulk material. Nanomaterials have substantial mechanical properties due to the volume, surface, and quantum effects of nanoparticles. This is observed when the nanoparticles are added to common bulk material, the nanomaterial refines the grain and forms intergranular and intragranular structures which improve the grain boundaries and therefore the mechanical properties of the materials. Grain boundary refinements provide strengthening by increasing the stress required to cause intergranular or transgranular fractures. A common example where this can be observed is the addition of nano Silica to cement, which improves the tensile strength, compressive strength, and bending strength by the mechanisms just mentioned. The understanding of these properties will enhance the use of nanoparticles in novel applications in various fields such as surface engineering, tribology, and nanomanufacturing /nanofabrication. Techniques Used: Steinitz in 1943 used the micro-indentation technique to test the hardness of microparticles, and now nanoindentation has been employed to measure elastic properties of particles at about 5-micron level. These protocols are frequently used to calculate the mechanical characteristics of nanoparticles via atomic force microscopy (AFM) techniques. To measure the elastic modulus; indentation data is obtained via AFM force-displacement curves being converted to force-indentation curves. Hooke’s law is used to determine the cantilever deformation and depth of the tip, and in conclusion, the pressure equation can be written as: P = k (ẟc - ẟc0) ẟc : cantilever deformation ẟc0 : deflection ofset AFM allows us to obtain a high-resolution image of multiple types of surfaces while the tip of the cantilever can be used to obtain information about mechanical properties. Computer simulations are also being progressively used to test theories and complement experimental studies. The most used computer method is molecular dynamics simulation, which uses newton’s equations of motion for the atoms or molecules in the system. Other techniques such direct probe method are used to determine the adhesive properties of nanomaterials. Both the technique and simulation are coupled with transmission electron microscope (TEM) and AFM techniques to provide results. We can categorize the mechanical properties of common nanomaterials classes: Crystalline metal nanomaterials: Dislocations are one of the major contributors toward elastic properties within nanomaterials similar to bulk crystalline materials. Despite the traditional view of there being no dislocations in nanomaterials. Ramos, experimental work has shown that the hardness of gold nanoparticles is much higher than their bulk counterparts, as there are stacking faults and dislocations forming that activate multiple strengthening mechanisms in the material. Through these experiments, more research has shown that via nanoindentation techniques, material strength; compressive stress, increases under compression with decreasing particle size, because of nucleating dislocations. These dislocations have been observed using TEM techniques, coupled with nanoindentation. Silicon nanoparticles strength and hardness are four times more than the value of the bulk material. The resistance to pressure applied can be attributed to the line defects inside the particles as well as a dislocation that provides strengthening of the mechanical properties of the nanomaterial. Furthermore, the addition of nanoparticles strengthens a matrix because the pinning of particles inhibits grain growth. This refines the grain, and hence improves the mechanical properties. However, not all additions of nanomaterials lead to an increase in properties for example nano-Cu. But this is attributed to the inherent properties of the material being weaker than the matrix. Nonmetallic Nanoparticles/ Nanomaterials:  Size-dependent behavior of mechanical properties is still not clear in the case of polymer nanomaterials however, in one research by Lahouij they found that the compressive moduli of polystyrene nanoparticles were found to be less than that of the bulk counterparts. This can be associated with the functional groups being hydrated. Furthermore, nonmetallic nanomaterials can lead to agglomerates forming inside the matrix they are being added to and hence decrease the mechanical properties by leading to fracture under even low mechanical loads, such as the addition of CNTs. The agglomerates will act as slip planes as well as planes in which cracks can easily propagate (9). However, most organic nanomaterials are flexible and these and the mechanical properties such as hardness etc. are not dominant. Nanowires/Nanotubes:  The elastic moduli of some nanowires namely lead and silver, decrease with increasing diameter. This has been associated with surface stress, oxidation layer, and surface roughness. However, the elastic behavior of ZnO nanowires does not get affected by surface effects but their fracture properties do. So, it is generally dependent on material behavior and their bonding as well. The reason why mechanical properties of nanomaterials are still a hot topic for research is that measuring the mechanical properties of individual nanoparticles is a complicated method, involving multiple control factors. Nonetheless, Atomic force microscopy has been widely used to measure the mechanical properties of nanomaterials. Adhesion and Friction of nanoparticles When talking about the application of a material adhesion and friction play a critical role in determining the outcome of the application. Therefore, it is critical to see how these properties also get affected by the size of a material. Again, AFM is a technique most used to measure these properties and to determine the adhesive strength of nanoparticles to any solid surface, along with the colloidal probe technique and other chemical properties. Furthermore, the forces playing a role in providing these adhesive properties to nanomaterials are either the electrostatic forces, VdW, capillary forces, solvation forces, structure force, etc. It has been found that the addition of nanomaterials in bulk materials substantially increases their adhesive capabilities by increasing their strength through various bonding mechanisms. Nanomaterials dimension approaches zero, which means that the fraction of the particle’s surface to overall atoms increases. Along with surface effects, the movement of nanoparticles also plays a role in dictating their mechanical properties such as shearing capabilities. The movement of particles can be observed under TEM. For example, the movement behavior of MoS2 nanoparticles dynamic contact was directly observed in situ which led to the conclusion that fullerenes can shear via rolling or sliding. However, observing these properties is again a very complicated process due to multiple contributing factors. Applications specific to Mechanical Properties: ·      Lubrication ·      Nano-manufacturing ·      Coatings


Uniformity

The chemical processing and synthesis of high performance technological components for the private, industrial and military sectors requires the use of high purity ceramics, polymers,
glass-ceramic Glass-ceramics are polycrystalline materials produced through controlled crystallization of base glass, producing a fine uniform dispersion of crystals throughout the bulk material. Crystallization is accomplished by subjecting suitable glasses t ...
s and material composites. In condensed bodies formed from fine powders, the irregular sizes and shapes of nanoparticles in a typical powder often lead to non-uniform packing morphologies that result in packing density variations in the powder compact. Uncontrolled
agglomeration Agglomeration may refer to: * Urban agglomeration, in standard English * Megalopolis, in Chinese English, as defined in China's ''Standard for basic terminology of urban planning'' (GB/T 50280—98). Also known as " city cluster". * Economies of ag ...
of powders due to attractive van der Waals forces can also give rise to in microstructural inhomogeneities. Differential stresses that develop as a result of non-uniform drying shrinkage are directly related to the rate at which the solvent can be removed, and thus highly dependent upon the distribution of porosity. Such stresses have been associated with a plastic-to-brittle transition in consolidated bodies, and can yield to
crack propagation Fracture mechanics is the field of mechanics concerned with the study of the propagation of cracks in materials. It uses methods of analytical solid mechanics to calculate the driving force on a crack and those of experimental solid mechanics t ...
in the unfired body if not relieved. In addition, any fluctuations in packing density in the compact as it is prepared for the kiln are often amplified during the sintering process, yielding inhomogeneous densification. Some pores and other structural defects associated with density variations have been shown to play a detrimental role in the sintering process by growing and thus limiting end-point densities. Differential stresses arising from inhomogeneous densification have also been shown to result in the propagation of internal cracks, thus becoming the strength-controlling flaws. It would therefore appear desirable to process a material in such a way that it is physically uniform with regard to the distribution of components and porosity, rather than using particle size distributions which will maximize the green density. The containment of a uniformly dispersed assembly of strongly interacting particles in suspension requires total control over particle-particle interactions. A number of dispersants such as ammonium citrate (aqueous) and imidazoline or oleyl alcohol (nonaqueous) are promising solutions as possible additives for enhanced dispersion and deagglomeration. Monodisperse nanoparticles and colloids provide this potential. Monodisperse powders of colloidal
silica Silicon dioxide, also known as silica, is an oxide of silicon with the chemical formula , most commonly found in nature as quartz and in various living organisms. In many parts of the world, silica is the major constituent of sand. Silica is ...
, for example, may therefore be stabilized sufficiently to ensure a high degree of order in the colloidal crystal or polycrystalline colloidal solid which results from aggregation. The degree of order appears to be limited by the time and space allowed for longer-range correlations to be established. Such defective polycrystalline colloidal structures would appear to be the basic elements of sub-micrometer colloidal materials science, and, therefore, provide the first step in developing a more rigorous understanding of the mechanisms involved in microstructural evolution in high performance materials and components.


Nanomaterials in articles, patents, and products

The quantitative analysis of nanomaterials showed that nanoparticles, nanotubes, nanocrystalline materials, nanocomposites, and graphene have been mentioned in 400000, 181000, 144000, 140000, and 119000 ISI-indexed articles, respectively, by Sep 2018. As far as patents are concerned, nanoparticles, nanotubes, nanocomposites, graphene, and nanowires have been played a role in 45600, 32100, 12700, 12500, and 11800 patents, respectively. Monitoring approximately 7000 commercial nano-based products available on global markets revealed that the properties of around 2330 products have been enabled or enhanced aided by nanoparticles. Liposomes, nanofibers, nanocolloids, and aerogels were also of the most common nanomaterials in consumer products. Th
European Union Observatory for Nanomaterials (EUON)
has produced a database
NanoData
that provides information on specific patents, products, and research publications on nanomaterials.


Health and safety


World Health Organization guidelines

The World Health Organization (WHO) published a guideline on protecting workers from potential risk of manufactured nanomaterials at the end of 2017. WHO used a precautionary approach as one of its guiding principles. This means that exposure has to be reduced, despite uncertainty about the adverse health effects, when there are reasonable indications to do so. This is highlighted by recent scientific studies that demonstrate a capability of nanoparticles to cross cell barriers and interact with cellular structures. In addition, the hierarchy of controls was an important guiding principle. This means that when there is a choice between control measures, those measures that are closer to the root of the problem should always be preferred over measures that put a greater burden on workers, such as the use of personal protective equipment (PPE). WHO commissioned systematic reviews for all important issues to assess the current state of the science and to inform the recommendations according to the process set out in the WHO Handbook for guideline development. The recommendations were rated as "strong" or "conditional" depending on the quality of the scientific evidence, values and preferences, and costs related to the recommendation. The WHO guidelines contain the following recommendations for safe handling of manufactured nanomaterials (MNMs) A. Assess health hazards of MNMs # WHO recommends assigning hazard classes to all MNMs according to the Globally Harmonized System (GHS) of Classification and Labelling of Chemicals for use in safety data sheets. For a limited number of MNMs this information is made available in the guidelines (strong recommendation, moderate-quality evidence). # WHO recommends updating safety data sheets with MNM-specific hazard information or indicating which toxicological end-points did not have adequate testing available (strong recommendation, moderate-quality evidence). # For the respirable fibres and granular biopersistent particles' groups, the GDG suggests using the available classification of MNMs for provisional classification of nanomaterials of the same group (conditional recommendation, low-quality evidence). B. Assess exposure to MNMs # WHO suggests assessing workers' exposure in workplaces with methods similar to those used for the proposed specific occupational exposure limit (OEL) value of the MNM (conditional recommendation, low-quality evidence). # Because there are no specific regulatory OEL values for MNMs in workplaces, WHO suggests assessing whether workplace exposure exceeds a proposed OEL value for the MNM. A list of proposed OEL values is provided in an annex of the guidelines. The chosen OEL should be at least as protective as a legally mandated OEL for the bulk form of the material (conditional recommendation, low-quality evidence). # If specific OELs for MNMs are not available in workplaces, WHO suggests a step-wise approach for inhalation exposure with, first an assessment of the potential for exposure; second, conducting basic exposure assessment and third, conducting a comprehensive exposure assessment such as those proposed by the Organisation for Economic Cooperation and Development (OECD) or Comité Européen de Normalisation (the European Committee for Standardization, CEN) (conditional recommendation, moderate quality evidence). # For dermal exposure assessment, WHO found that there was insufficient evidence to recommend one method of dermal exposure assessment over another. C. Control exposure to MNMs # Based on a precautionary approach, WHO recommends focusing control of exposure on preventing inhalation exposure with the aim of reducing it as much as possible (strong recommendation, moderate-quality evidence). # WHO recommends reduction of exposures to a range of MNMs that have been consistently measured in workplaces especially during cleaning and maintenance, collecting material from reaction vessels and feeding MNMs into the production process. In the absence of toxicological information, WHO recommends implementing the highest level of controls to prevent workers from any exposure. When more information is available, WHO recommends taking a more tailored approach (strong recommendation, moderate-quality evidence). # WHO recommends taking control measures based on the principle of hierarchy of controls, meaning that the first control measure should be to eliminate the source of exposure before implementing control measures that are more dependent on worker involvement, with PPE being used only as a last resort. According to this principle, engineering controls should be used when there is a high level of inhalation exposure or when there is no, or very little, toxicological information available. In the absence of appropriate engineering controls PPE should be used, especially respiratory protection, as part of a respiratory protection programme that includes fit-testing (strong recommendation, moderate-quality evidence). # WHO suggests preventing dermal exposure by occupational hygiene measures such as surface cleaning, and the use of appropriate gloves (conditional recommendation, low quality evidence). # When assessment and measurement by a workplace safety expert is not available, WHO suggests using control banding for nanomaterials to select exposure control measures in the workplace. Owing to a lack of studies, WHO cannot recommend one method of control banding over another (conditional recommendation, very low-quality evidence). For health surveillance WHO could not make a recommendation for targeted MNM-specific health surveillance programmes over existing health surveillance programmes that are already in use owing to the lack of evidence. WHO considers training of workers and worker involvement in health and safety issues to be best practice but could not recommend one form of training of workers over another, or one form of worker involvement over another, owing to the lack of studies available. It is expected that there will be considerable progress in validated measurement methods and risk assessment and WHO expects to update these guidelines in five years' time, in 2022.


Other guidance

Because nanotechnology is a recent development, the health and safety effects of exposures to nanomaterials, and what levels of exposure may be acceptable, are subjects of ongoing research. Of the possible hazards,
inhalation exposure Inhalation is a major route of exposure that occurs when an individual breathes in polluted air which enters the respiratory tract. Identification of the pollutant uptake by the respiratory system can determine how the resulting exposure contrib ...
appears to present the most concern. Animal studies indicate that carbon nanotubes and
carbon nanofiber Carbon nanofibers (CNFs), vapor grown carbon fibers (VGCFs), or vapor grown carbon nanofibers (VGCNFs) are cylindrical nanostructures with graphene layers arranged as stacked cone (geometry), cones, cups or plates. Carbon nanofibers with graphene ...
s can cause pulmonary effects including inflammation, granulomas, and pulmonary fibrosis, which were of similar or greater potency when compared with other known
fibrogenic Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of perman ...
materials such as
silica Silicon dioxide, also known as silica, is an oxide of silicon with the chemical formula , most commonly found in nature as quartz and in various living organisms. In many parts of the world, silica is the major constituent of sand. Silica is ...
, asbestos, and ultrafine carbon black. Acute inhalation exposure of healthy animals to biodegradable inorganic nanomaterials have not demonstrated significant toxicity effects. Although the extent to which animal data may predict clinically significant lung effects in workers is not known, the toxicity seen in the short-term animal studies indicate a need for protective action for workers exposed to these nanomaterials, although no reports of actual adverse health effects in workers using or producing these nanomaterials were known as of 2013. Additional concerns include skin contact and ingestion exposure, and dust explosion hazards. Elimination and
substitution Substitution may refer to: Arts and media *Chord substitution, in music, swapping one chord for a related one within a chord progression *Substitution (poetry), a variation in poetic scansion * "Substitution" (song), a 2009 song by Silversun Pic ...
are the most desirable approaches to hazard control. While the nanomaterials themselves often cannot be eliminated or substituted with conventional materials, it may be possible to choose properties of the nanoparticle such as
size Size in general is the magnitude or dimensions of a thing. More specifically, ''geometrical size'' (or ''spatial size'') can refer to linear dimensions ( length, width, height, diameter, perimeter), area, or volume. Size can also be me ...
, shape, functionalization, surface charge, solubility,
agglomeration Agglomeration may refer to: * Urban agglomeration, in standard English * Megalopolis, in Chinese English, as defined in China's ''Standard for basic terminology of urban planning'' (GB/T 50280—98). Also known as " city cluster". * Economies of ag ...
, and aggregation state to improve their toxicological properties while retaining the desired functionality. Handling procedures can also be improved, for example, using a nanomaterial slurry or suspension in a liquid solvent instead of a dry powder will reduce dust exposure. Engineering controls are physical changes to the workplace that isolate workers from hazards, mainly ventilation systems such as fume hoods, gloveboxes, biosafety cabinets, and vented balance enclosures. Administrative controls are changes to workers' behavior to mitigate a hazard, including training on
best practice A best practice is a method or technique that has been generally accepted as superior to other known alternatives because it often produces results that are superior to those achieved by other means or because it has become a standard way of doing ...
s for safe handling, storage, and disposal of nanomaterials, proper awareness of hazards through labeling and warning signage, and encouraging a general safety culture. Personal protective equipment must be worn on the worker's body and is the least desirable option for controlling hazards. Personal protective equipment normally used for typical chemicals are also appropriate for nanomaterials, including long pants, long-sleeve shirts, and closed-toed shoes, and the use of safety gloves, goggles, and impervious
laboratory coat A white coat, also known as a laboratory coat or lab coat, is a knee-length overcoat or smock worn by professionals in the medical field or by those involved in laboratory work. The coat protects their street clothes and also serves as a simple ...
s. In some circumstances respirators may be used.
Exposure assessment Exposure assessment is a branch of environmental science and occupational hygiene that focuses on the processes that take place at the interface between the environment containing the contaminant of interest and the organism being considered. ...
is a set of methods used to monitor contaminant release and exposures to workers. These methods include personal sampling, where samplers are located in the personal breathing zone of the worker, often attached to a shirt collar to be as close to the nose and mouth as possible; and area/background sampling, where they are placed at static locations. The assessment should use both particle counters, which monitor the real-time quantity of nanomaterials and other background particles; and filter-based samples, which can be used to identify the nanomaterial, usually using electron microscopy and
elemental analysis Elemental analysis is a process where a sample of some material (e.g., soil, waste or drinking water, bodily fluids, minerals, chemical compounds) is analyzed for its elemental and sometimes isotopic composition. Elemental analysis can be qualit ...
. As of 2016, quantitative occupational exposure limits have not been determined for most nanomaterials. The U.S. National Institute for Occupational Safety and Health has determined non-regulatory recommended exposure limits for carbon nanotubes,
carbon nanofiber Carbon nanofibers (CNFs), vapor grown carbon fibers (VGCFs), or vapor grown carbon nanofibers (VGCNFs) are cylindrical nanostructures with graphene layers arranged as stacked cone (geometry), cones, cups or plates. Carbon nanofibers with graphene ...
s, and ultrafine titanium dioxide. Agencies and organizations from other countries, including the British Standards Institute and the Institute for Occupational Safety and Health in Germany, have established OELs for some nanomaterials, and some companies have supplied OELs for their products. Nanoscale Diagnostics Nanotechnology has been making headlines in the medical field, being responsible for biomedical imaging. The unique optical, magnetic and chemical properties of materials on the Nano scale has allowed the development of imaging probes with multi-functionality such as better contrast enhancement, better spatial information, controlled bio distribution, and multi-modal imaging across various scanning devices. These developments have had advantages such as being able to detect the location of tumors and inflammations, accurate assessment of disease progression, and personalized medicine. # Silica Nanoparticles- Silica nanoparticles can be classified into solid, non-porous, and mesoporous. They have large surface are, hydrophilic surface, and chemical and physical stabilities. Silica nanoparticles are made by the use of the Stöber process. Which is the hydrolysis of silyl ethers such as tetraethyl silicate into silanols (Si-OH) using ammonia in a mixture of water and alcohol followed by the condensation of silanols into 50-2000 nm silica particles. The size of the particle can be controlled by varying the concentration of silyl ether and alcohol or the micro emulsion method. Mesoporous silica nanoparticles are synthesized by the sol-gel process. They have pores that range in diameter from 2 nm to 50 nm. They are synthesized in a water-based solution in the presence of a base catalyst and a pore forming agent known as a surfactant. Surfactants are molecules that present the particularity to have a hydrophobic tail (alkyl chain) and a hydrophilic head (charged group, such as a quaternary amine for example). As these surfactants are added to a water-based solution, they will coordinate to form micelles with increasing concentration in order to stabilize the hydrophobic tails. Varying the pH of the solution and composition of the solvents, and the addition of certain swelling agents can control the pore size. Their hydrophilic surface is what makes silica nanoparticles so important and allows them to carry out functions such as drug and gene delivery, bio imaging and therapy. In order for this application to be successful, assorted surface functional groups are necessary and can be added either by the co-condensation process during preparation or by post surface modification. The high surface area of silica nanoparticles allows them to carry much larger amounts of the desired drug than through conventional methods like polymers and liposomes. It allows for site specific targeting, especially in the treatment of cancer. Once the particles have reached their destination, they can act as a reporter, release a compound, or be remotely heated to damage biological structures in close proximity.  Targeting is typically accomplished by modifying the surface of the nanoparticle with a chemical or biological compound. They accumulate at tumor sites through Enhanced Permeability Retention (EPR), where the tumor vessels accelerate the delivery of the nanoparticles directly into the tumor. The porous shell of the silica allows control over the rate at which the drug diffuses out of the nanoparticle. The shell can be modified to have an affinity for the drug, or even to be triggered by pH, heat, light, salts or other signaling molecules. Silica nanoparticles are also used in bio imaging because they can accommodate fluorescent/MRI/PET/ SPECT contrast agents and drug/DNA molecules to their adaptable surface and pores. This is made possible by using the silica nanoparticle as a vector for the expression of fluorescent proteins. Several different types of fluorescent probes, like cyanine dyes, methyl violegen, or semiconductor quantum dots can be conjugated to silica nanoparticles and delivered into specific cells or injected in vivo. Carrier molecule RGD peptide has been very useful of targeted in vivo imaging. # Topically applied surface-enhanced resonance Raman ratiometric spectroscopy (TAS3RS)- TAS3RS is another technique that is starting to make advancement in the medical field. It is an imaging technique that uses Folate Receptors (FR) to detect tumor lesions as small as 370 micrometers. Folate Receptors are membrane bound surface proteins that bind folates and folate conjugates with high affinity. FR is frequently overexpressed in a number of human malignancies including cancer of the ovary, lung, kidney, breast, bladder, brain, and endometrium. Raman imaging is a type of spectroscopy that is used in chemistry to provide structural fingerprint by which molecules can be identified. It relies upon inelastic scattering of photons, which result in ultra high sensitivity. There was a study that was done where two different surface enhanced resonance Raman scattering were synthesized (SERRS). One of the SERRS was a “targeted nanoprobe functionalized with an anti-folate-receptor antibody (αFR-Ab) via a PEG-maleimide-succinimide and using the infrared dye IR780 as the Raman reporter, henceforth referred to as αFR-NP, and a nontargeted probe (nt-NP) coated with PEG5000-maleimide and featuring the IR140 infrared dye as the Raman reporter.” These two different mixtures were injected into tumor bearing mice and healthy controlled mice. The mice were imaged with Bioluminescence (BLI) signal that produces light energy within an organism's body. They were also scanned with the Raman microscope in order to be able to see the correlation between the TAS3RS and the BLI map. TAS3RS did not show anything in the healthy mice, but was able to locate the tumor lesions in the infected mice and also able to create a TAS3RS map that could be used as guidance during surgery. TAS3RS shows to be promising in being able to combat ovarian and peritoneal cancer as it allows early detection with high accuracy. This technique can be administered locally, which is an advantage as it does not have to enter the bloodstream and therefore bypassing the toxicity concerns circulating nanoprobes.  This technique is also more photostable than fluorochromes because SERRS nanoparticles cannot form from biomolecules and therefore there would not be any false positives in TAS3RS as there is in fluorescence imaging.


See also

*
Directional freezing Directional freezing freezes from only one direction. Directional freezing can freeze water, from only one direction or side of a container, into clear ice. Directional freezing in a domestic freezer can be done by putting water in a insulated ...
* Nanostructure *
Nanotopography Nanotopography refers to specific surface features which form or are generated at the nanoscopic scale. While the term can be used to describe a broad range of applications ranging from integrated circuits to microfluidics, in practice it typicall ...
*
Nanozymes An artificial enzyme is a synthetic organic molecule or ion that recreates one or more functions of an enzyme. It seeks to deliver catalysis at rates and selectivity observed in naturally occurring enzymes. History Enzyme catalysis of chemical r ...
* List of software for nanostructures modeling *
Artificial enzyme An artificial enzyme is a synthetic organic molecule or ion that recreates one or more functions of an enzyme. It seeks to deliver catalysis at rates and selectivity observed in naturally occurring enzymes. History Enzyme catalysis of chemical re ...


References


External links


European Union Observatory for Nanomaterials (EUON)

Acquisition, evaluation and public orientated presentation of societal relevant data and findings for nanomaterials (DaNa)
* ttp://copublications.greenfacts.org/en/nanotechnologies/index.htm Assessing health risks of nanomaterialssummary by GreenFacts of the European Commission SCENIHR assessment
International Liposome SocietyTextiles Nanotechnology Laboratory
at Cornell University
IOP.org ArticleNano Structured MaterialOnline course MSE 376-Nanomaterials by Mark C. Hersam (2006)Nanomaterials: Quantum Dots, Nanowires and Nanotubes
online presentation by Dr Sands

NEDO 2012 * ttp://spie.org/newsroom/engheta-video Nader Engheta: Wave interaction with metamaterials SPIE Newsroom 2016
Managing nanomaterials in the Workplace
by the European Agency for Safety and Health at Work. {{Authority control Emerging technologies