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History
In the mid-twentieth century, mumps infections among children were not viewed as a serious public health issue, but adult men may develop debilitating testicular
A testicle or testis (plural testes) is the male reproductive gland or gonad in all bilaterians, including humans. It is homologous to the female ovary. The functions of the testes are to produce both sperm and androgens, primarily testosteron ...
inflammation, which posed particular difficulty among close-quartered soldiers during wartime. As a result, during World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
(1939-1945), the United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country Continental United States, primarily located in North America. It consists of 50 U.S. state, states, a Washington, D.C., ...
government targeted mumps for scientific research. The first experimental mumps vaccine was licensed in 1948; developed from inactivated virus, it only had short-term effectiveness.
Improved vaccines became commercially available in the 1960s. In 1963, Maurice Hilleman
Maurice Ralph Hilleman (August 30, 1919 – April 11, 2005) was a leading American microbiologist who specialized in vaccinology and developed over 40 vaccines, an unparalleled record of productivity. According to one estimate, his vaccines ...
of Merck & Co. took samples of the mumps virus from his daughter, who had contracted the disease; she became the namesake for the resulting ''Jeryl Lynn Jeryl Lynn are strains of mumps virus used in the Mumpsvax mumps vaccine made by Merck. The strains are named after Jeryl Lynn Hilleman. In 1963, Jeryl's father, Maurice Hilleman, was leading efforts to produce a mumps vaccine for Merck. He cu ...
'' strain. Building on then-recent advances that had led to vaccines for polio
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe sy ...
and measles
Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...
, the mumps virus strains were developed in embryonic hens' eggs and chick embryo cell cultures. The resulting strains of virus were less well-suited for human cells, and are thus said to be ''attenuated''. They are sometimes referred to as ''neuroattenuated'' in the sense that these strains are less virulent to human neuron
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa ...
s than the wild strains.
Hilleman's work led to the first effective mumps vaccine, called Mumpsvax. Licensed in 1967, its four-year development set a record for fastest development of a new vaccine, a record later surpassed by the COVID-19 vaccine
A COVID19 vaccine is a vaccine intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 (COVID19).
Prior to the COVID19 pandemic, an e ...
, which was developed in less than a year.
Vaccination against mumps did not become routine until Mumpsvax was included in Merck's combined MMR vaccine
The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as ''MMR''. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, ...
, which targeted measles
Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, ...
and rubella
Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus. This disease is often mild, with half of people not realizing that they are infected. A rash may start around two weeks after exposure and ...
along with mumps. MMR was licensed in 1971, and 40 percent of American children had received the combined vaccine by 1974. In 1977, the U.S. Centers for Disease Control and Prevention
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georg ...
(CDC) recommended mumps immunization (as part of MMR) for all children over 12 months of age, and in 1998, CDC began recommending a two-dose immunization of MMR.
Types
While the initial vaccine in the 1940s was based on inactivated virus, subsequent preparations since the 1960s consist of live virus that has been weakened. Mumps vaccine is on the World Health Organization's List of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...
. There are a number of different types in use as of 2007.
Mumpsvax is Merck's brand of Jeryl Lynn Jeryl Lynn are strains of mumps virus used in the Mumpsvax mumps vaccine made by Merck. The strains are named after Jeryl Lynn Hilleman. In 1963, Jeryl's father, Maurice Hilleman, was leading efforts to produce a mumps vaccine for Merck. He cu ...
strain vaccines. It is a component of Merck's three-virus MMR vaccine
The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as ''MMR''. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, ...
, and is the mumps vaccine standard in the United States. Mumpsvax is given by a subcutaneous injection
Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion.
A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, c ...
of live virus reconstituted from freeze-dried (lyophilized
Freeze drying, also known as lyophilization or cryodesiccation, is a low temperature dehydration process that involves freezing the product and lowering pressure, removing the ice by sublimation. This is in contrast to dehydration by most conve ...
) vaccine. Production of Mumpsvax as a stand-alone product ceased in 2009.
The cells used in culture, virus stocks used, and animal fluids are all screened for extraneous material as part of the vaccine production. They are grown in Medium 199 (a solution containing buffered salt, vitamins, amino acids, fetal bovine serum) with SPGA
A pin grid array (PGA) is a type of integrated circuit packaging. In a PGA, the package is square or rectangular, and the pins are arranged in a regular array on the underside of the package. The pins are commonly spaced 2.54 mm (0.1") a ...
(sucrose, phosphate, glutamate, human serum albumin) and neomycin
Neomycin is an aminoglycoside antibiotic that displays bactericidal activity against gram-negative aerobic bacilli and some anaerobic bacilli where resistance has not yet arisen. It is generally not effective against gram-positive bacilli and ...
. The human albumin processing uses the Cohn cold ethanol fractionation method.
Other types
* RIT 4385 is a newer strain derived from the Jeryl Lynn strain by Maurice Hilleman
Maurice Ralph Hilleman (August 30, 1919 – April 11, 2005) was a leading American microbiologist who specialized in vaccinology and developed over 40 vaccines, an unparalleled record of productivity. According to one estimate, his vaccines ...
, Jeryl Lynn's father.
* Leningrad-3 strain was developed by Smrodintsev and Klyachko in guinea pig kidney cell culture and has been used since 1950 in former Soviet countries. This vaccine is routinely used in Russia.
* L-Zagreb strain used in Croatia
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, image_coat = Coat of arms of Croatia.svg
, anthem = " Lijepa naša domovino"("Our Beautiful Homeland")
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and India
India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area, the List of countries and dependencies by population, second-most populous ...
was derived from the Leningrad-3 strain by further passaging.
* Urabe strain was introduced in Japan, and later licensed in Belgium, France and Italy. It has been associated with a higher incidence of meningitis (1/143 000 versus 1/227 000 for J-L), and abandoned in several countries. It was formulated as MMR in the UK.
* Rubini strain used mainly in Switzerland
). Swiss law does not designate a ''capital'' as such, but the federal parliament and government are installed in Bern, while other federal institutions, such as the federal courts, are in other cities (Bellinzona, Lausanne, Luzern, Neuchâtel ...
was attenuated by a higher number of passes through chicken embryos, and later proved to have low potency. It was introduced in 1985.
Illegal importation of ineffective version into the UK
Monovalent mumps vaccine (Mumpsvax) remained available in the US when MMR was introduced in the UK, replacing the MR (measles and rubella) mixed vaccine. No UK-licensed monovalent preparation was ever available. Monovalent mumps vaccines were available before MMR, but only used on a limited scale. This became the subject of considerable argument at the end of the 20th century, since some parents preferred to obtain individually the components of the MMR mixture. One mumps vaccine preparation imported into the United Kingdom and unlicensed, proved to be essentially ineffective.[Pavivac ineffective]
CMO's letter HSSMD33-02
: Nov. 2002 Immunisation against mumps in the UK became routine in 1988, commencing with MMR. The Aventis-Pasteur "MMR-2" brand is usual in the UK in 2006.
Storage and stability
The cold chain
A cold chain is a low temperature-controlled supply chain network. An unbroken cold chain is an uninterrupted series of refrigerated production, storage and distribution activities, along with associated equipment and logistics, which maintain qu ...
is a major consideration in vaccination, particularly in less-developed countries. Mumps vaccines are normally refrigerated, but have a long half-life of 65 days at 23 degrees Celsius.
References
Further reading
Mumps (The History of Vaccines)
External links
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{{DEFAULTSORT:Mumps Vaccine
1948 in biology
Live vaccines
Mumps
Wikipedia medicine articles ready to translate
Vaccines
World Health Organization essential medicines (vaccines)