Mitozolomide (

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) is an antineoplastic. It is an imidazotetrazine derivative. Development of mitozolomide was discontinued during

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clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

s after it was found to cause severe and unpredictable

bone marrow suppression Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (t ...

Temozolomide Temozolomide (TMZ), sold under the brand name Temodar among others, is a medication used to treat brain tumors such as glioblastoma and anaplastic astrocytoma. Text was copied from this source which is © European Medicines Agency. Reproduction i ...

, which has been in clinical use since 1999, is a less toxic analogue of mitozolomide.

References

Abandoned drugs Imidazotetrazines Carboxamides Organochlorides {{antineoplastic-drug-stub