NomenclatureSystematic names are formed as "''substrate group-lyase''." Common names include decarboxylase, dehydratase, aldolase, etc. When the product is more important, synthase may be used in the name, e.g. phosphosulfolactate synthase (EC 220.127.116.11, Michael addition of sulfite to phosphoenolpyruvate). A combination of both an elimination and a Michael addition is seen in O-succinylhomoserine (thiol)-lyase (MetY or MetZ) which catalyses first the γ-elimination of O-succinylhomoserine (with succinate as a leaving group) and then the addition of sulfide to the vinyl intermediate, this reaction was first classified as a lyase (EC 18.104.22.168), but was then reclassified as a transferase (EC 22.214.171.124).
ClassificationLyases are classified as EC 4 in the Enzyme Commission number, EC number classification of enzymes. Lyases can be further classified into seven subclasses: *:EC 4.1, EC 4.1 includes lyases that cleave carbon–carbon bonds, such as decarboxylases (EC 4.1.1), aldehyde lyases (EC 4.1.2), oxo acid lyases (EC 4.1.3), and others (EC 4.1.99) *:EC 4.2, EC 4.2 includes lyases that cleave carbon–oxygen bonds, such as dehydratases *:EC 4.3, EC 4.3 includes lyases that cleave carbon–nitrogen bonds *:EC 4.4, EC 4.4 includes lyases that cleave carbon–sulfur bonds *:EC 4.5, EC 4.5 includes lyases that cleave carbon–halide bonds *:EC 4.6, EC 4.6 includes lyases that cleave phosphorus–oxygen bonds, such as adenylyl cyclase and guanylyl cyclase *:EC 4.99, EC 4.99 includes other lyases, such as ferrochelatase
Membrane-associated lyasesSome lyases associate with biological membranes as peripheral membrane proteins or anchored through a single transmembrane helix.
See also*List of EC numbers (EC 4), List of EC numbers of enzymes belonging to category EC 4