The lateral corticospinal tract (also called the crossed pyramidal tract or lateral cerebrospinal fasciculus) is the largest part of the

corticospinal tract The corticospinal tract is a white matter motor pathway starting at the cerebral cortex that terminates on lower motor neurons and interneurons in the spinal cord, controlling movements of the limbs and trunk. There are more than one million neur ...

. It extends throughout the entire length of the

spinal cord The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spi ...

, and on transverse section appears as an oval area in front of the

posterior column Posterior may refer to: * Posterior (anatomy), the end of an organism opposite to its head ** Buttocks, as a euphemism * Posterior horn (disambiguation) * Posterior probability The posterior probability is a type of conditional probability that r ...

and medial to the

posterior spinocerebellar tract The spinocerebellar tract is a nerve tract originating in the spinal cord and terminating in the same side (ipsilateral) of the cerebellum. Origins of proprioceptive information Proprioceptive information is obtained by Golgi tendon organs and ...

Structure

Descending motor pathways carry motor signals from the brain down the spinal cord and to the target muscle or organ. They typically consist of an upper

motor neuron A motor neuron (or motoneuron or efferent neuron) is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectl ...

and a lower motor neuron. The lateral corticospinal tract is a descending motor pathway that begins in the cerebral cortex, decussates in the pyramids of the lower medulla (also known as the medulla oblongata or the cervicomedullary junction, which is the most posterior division of the brain) and proceeds down the contralateral side of the spinal cord. It is the largest part of the

. It extends throughout the entire length of the

medulla spinalis The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spin ...

, and on transverse section appears as an oval area in front of the

and medial to the

Function

Axons in the lateral corticospinal tract weave out of the tract and into the anterior horns of the spinal cord. It controls fine movement of ipsilateral limbs (albeit contralateral to the corresponding motor cortex) as it lies distal to the

pyramidal decussation In neuroanatomy, the medullary pyramids are paired white matter structures of the brainstem's medulla oblongata that contain motor fibers of the corticospinal and corticobulbar tracts – known together as the pyramidal tracts. The lower limit ...

. Control of more central axial and girdle muscles comes from the

anterior corticospinal tract The anterior corticospinal tract (also called the ventral corticospinal tract, "Bundle of Turck", medial corticospinal tract, direct pyramidal tract, or anterior cerebrospinal fasciculus) is a small bundle of descending fibers that connect the cer ...

. Damage to different parts of the body will cause deficits, depending on whether the damage is above (rostral) or below (caudal) the pyramidal decussation. Damage to the body above the pyramidal decussation will cause contralateral motor deficits. For example, if there is a lesion at the pre-central gyrus in the right cerebral cortex, then the left side of the body will be affected. Whereas damage below the pyramidal decussation will result in ipsilateral motor deficits. For example, spinal cord damage on the left side of the lateral corticospinal tract at the thoracic level can cause motor deficits to the left side of the body.

Clinical significance

Strokes, spinal muscular atrophy, Brown Sequard Syndrome,

poliomyelitis Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe sym ...

and

amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) or Lou Gehrig's disease, is a neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles. ALS is the most comm ...

are all pathologies that could affect the lateral corticospinal tract. Damage to the lower motor neurons could pose a risk of muscle atrophy and other disorders.

Additional images

Image:Gray680.png, Decussation of pyramids. Image:Gray687.png, Section of the medulla oblongata through the lower part of the

decussation of the pyramids In neuroanatomy, the medullary pyramids are paired white matter structures of the brainstem's medulla oblongata that contain motor fibers of the corticospinal and corticobulbar tracts – known together as the pyramidal tracts. The lower limit ...

Image:Gray688.png, Section of the medulla oblongata at the level of the decussation of the pyramids. Image:Gray764.png, The motor tract.

References

External links

*
Overview at thebrain.mcgill.ca
* {{Authority control Motor system Spinal cord tracts