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A craniotomy is a
surgical operation Surgery ''cheirourgikē'' (composed of χείρ, "hand", and ἔργον, "work"), via la, chirurgiae, meaning "hand work". is a medical specialty that uses operative manual and instrumental techniques on a person to investigate or treat a pat ...
in which a bone flap is temporarily removed from the
skull The skull is a bone protective cavity for the brain. The skull is composed of four types of bone i.e., cranial bones, facial bones, ear ossicles and hyoid bone. However two parts are more prominent: the cranium and the mandible. In humans, th ...
to access the brain. Craniotomies are often critical operations, performed on patients who are suffering from brain lesions, such as tumors, blood clots, removal of foreign bodies such as bullets, or
traumatic brain injury A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused by an external force. TBI can be classified based on severity (ranging from mild traumatic brain injury TBI/concussionto severe traumatic ...
(TBI), and can also allow doctors to surgically implant devices, such as deep brain stimulators for the treatment of
Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms beco ...
,
epilepsy Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical ...
, and cerebellar tremor. The procedure is also used in epilepsy surgery to remove the parts of the brain that are causing epilepsy. Craniotomy is distinguished from
craniectomy Decompressive craniectomy ('' crani-'' + '' -ectomy'') is a neurosurgical procedure in which part of the skull is removed to allow a swelling brain room to expand without being squeezed. It is performed on victims of traumatic brain injury, str ...
(in which the skull flap is not immediately replaced, allowing the brain to swell, thus reducing intracranial pressure) and from
trepanation Trepanning, also known as trepanation, trephination, trephining or making a burr hole (the verb ''trepan'' derives from Old French from Medieval Latin from Greek , literally "borer, auger"), is a surgical intervention in which a hole is drille ...
, the creation of a burr hole through the cranium in to the
dura mater In neuroanatomy, dura mater is a thick membrane made of dense irregular connective tissue that surrounds the brain and spinal cord. It is the outermost of the three layers of membrane called the meninges that protect the central nervous system. ...
.


Procedure

Human craniotomy is usually performed under general anesthesia but can be also done with the patient awake using a local anaesthetic; the procedure, typically, does not involve significant discomfort for the patient. In general, a craniotomy will be preceded by an
MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves ...
scan which provides an image of the brain that the surgeon uses to plan the precise location for bone removal and the appropriate angle of access to the relevant brain areas. The amount of skull that needs to be removed depends on the type of surgery being performed. The bone flap is mostly removed with the help of a
cranial drill A cranial drill, also known as a craniotome, is a tool for drilling simple burr holes (trepanation) or for creating larger openings in the skull. This exposes the brain and allows operations like craniotomy and craniectomy to be done. The drill ...
and a craniotome, then replaced using titanium plates and screws or another form of fixation (wire, suture, etc.) after completion of the surgical procedure. In the event the host bone does not accept its replacement an artificial piece of skull, often made of
PEEK Polyether ether ketone (PEEK) is a colourless organic thermoplastic polymer in the polyaryletherketone (PAEK) family, used in engineering applications. The polymer was first developed in November 1978, later being introduced to the market by Vic ...
, is substituted. (The PEEK appliance is routinely modeled by a
CNC Numerical control (also computer numerical control, and commonly called CNC) is the automated control of machining tools (such as drills, lathes, mills, grinders, routers and 3D printers) by means of a computer. A CNC machine processes a p ...
machine capable of accepting a high resolution
MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves ...
computer file in order to provide a very close fit, in an effort to minimize fitment issues, and therefore minimizing the duration of the cranial surgery.)


Complications

Bacterial meningitis Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or ...
or viral meningitis occurs in about 0.8 to 1.5% of individuals undergoing craniotomy. Postcraniotomy pain is frequent and moderate to severe in nature. This pain has been controlled through the use of scalp infiltrations, nerve scalp blocks,
parecoxib Parecoxib, sold under the brand name Dynastat among others, is a water-soluble and injectable prodrug of valdecoxib. Parecoxib is a COX2 selective inhibitor. It is injectable. It is approved through much of Europe for short term perioperative ...
, and
morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. There ...
, morphine being the most effective in providing analgesia. According to the Journal of Neurosurgery, ''Infections in patients undergoing craniotomy: risk factors associated with post-craniotomy meningitis'', their clinical studies indicated that "the risk for meningitis was independently associated with perioperative steroid use and ventricular drainage". Within the 334 procedures that they had conducted from males and females, their results concluded that traumatic brain injuries were the predominant causes of bacterial meningitis. At least 40% of patients became susceptible to at least one infection, creating more interconnected risk factors along the way. From the Infectious Diseases Clinic Erasme Hospital, there had been reports of infections initially beginning from either the time of surgery, skin intrusion, hematogenous seeding, or retrograde infections. Cerebrospinal fluid shunt (CSF) associates with the risk of meningitis due to the following factors: pre-shunt associated infections, post-operative CSF leakage, lack of experience from the neurosurgeon,
premature birth Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 2 ...
/young age, advanced age, shunt revisions for dysfunction, and neuroendoscopes. The way shunts are operated on each patient relies heavily on the cleanliness of the site. Once bacteria penetrates the area of a CSF, the procedure becomes more complicated. The skin is especially necessary to address because it is an external organ. Scratching the incision site can easily create an infection due to there being no barrier between the open air and wound. Aside from scratching, decubitus ulcer and tissues near the shunt site are also leading pathways for infection susceptibility. It is also common to give patients seven days of anti-seizure medications post operatively. Traditionally this has been
phenytoin Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. The int ...
, but now is increasingly
levetiracetam Levetiracetam, sold under the brand name Keppra among others, is a medication used to treat epilepsy. It is used for partial-onset, myoclonic, or tonic–clonic seizures and is taken either by mouth as an immediate or extended release form ...
as it has a lower risk of drug-drug interactions.


See also

*
Decompressive craniectomy Decompressive craniectomy ('' crani-'' + '' -ectomy'') is a neurosurgical procedure in which part of the skull is removed to allow a swelling brain room to expand without being squeezed. It is performed on victims of traumatic brain injury, str ...
*
Trepanning Trepanning, also known as trepanation, trephination, trephining or making a burr hole (the verb ''trepan'' derives from Old French from Medieval Latin from Greek , literally "borer, auger"), is a surgical intervention in which a hole is drille ...


References


External links

{{Central nervous system tests and procedures Neurosurgical procedures