A fundic gland polyp is a type of polyp, found in the fundus of the

stomach The stomach is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach i ...

. Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo

esophagogastroduodenoscopy Esophagogastroduodenoscopy (EGD) or oesophagogastroduodenoscopy (OGD), also called by various other names, is a diagnostic endoscopic procedure that visualizes the upper part of the gastrointestinal tract down to the duodenum. It is considered ...

, and are more common in middle-aged women. The risk of malignancy is very low or none, when sporadic.

Fundic gland polyposis Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. The condition has been described both in patients with familial adenomatous polyposis (FAP) and attenuated variants (AFAP) ...

is a medical syndrome with multiple fundic gland polyps. The condition has been described both in patients with

familial adenomatous polyposis Familial adenomatous polyposis (FAP) is an autosomal dominant inherited condition in which numerous Adenomatous polyps, adenomatous Colorectal polyp, polyps form mainly in the epithelium of the colon (anatomy), large intestine. While these polyps s ...

(FAP) and attenuated variants (AFAP), and in patients in whom it occurs sporadically. File:Pie chart of relative incidences of gastric polyps.png, Relative incidences of gastric polyps (with fundic gland polyp at upper right). File:Histopathology of fundic gland polyp, high magnification, annotated.jpg, The glands are lined by

chief cell In human anatomy, there are three types of chief cells, the gastric chief cell, the parathyroid chief cell, and the type 1 chief cells found in the carotid body. Cell types The gastric chief cell (also known as a zymogenic cell or peptic cell) i ...

s and

parietal cell Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the ...

s, and possibly also mucinous foveolar cells. File:Histopathology of a fundic gland polyp with dysplasia.jpg, Fundic gland polyp with dysplasia (center), compared to normal mucosa (at right).

References

{{reflist Diseases and disorders