Fructose 6-phosphate (sometimes called the Neuberg ester) is a derivative of fructose, which has been

phosphorylated In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...

at the 6-hydroxy group. It is one of several possible fructosephosphates. The β-D-form of this compound is very common in cells. The great majority of

glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, u ...

is converted to fructose 6-phosphate upon entering a cell. Fructose is predominantly converted to

fructose 1-phosphate Fructose-1-phosphate is a derivative of fructose. It is generated mainly by hepatic fructokinase but is also generated in smaller amounts in the small intestinal mucosa and proximal epithelium of the renal tubule. It is an important intermediate o ...

fructokinase Fructokinase (/fruc•to•ki•nase/ ki´nas, also known as D-fructokinase or D-fructose (D-mannose) kinase,Carl Neuberg Carl Alexander Neuberg (29 July 1877 – 30 May 1956) was an early pioneer in biochemistry, and he is often referred to as the "father of modern biochemistry". His notable contribution to science includes the discovery of the carboxylase and the ...

. In 1918, he found that the compound (later identified as fructose 6-phosphate) was beproduced by mild acid hydrolysis of

fructose 2,6-bisphosphate Fructose 2,6-bisphosphate, abbreviated Fru-2,6-''P''2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. F ...

.Fruton, Joseph S. ''Proteins, Enzymes, Genes: The Interplay of Chemistry and Biology''. Yale University Press: New Haven, 1999. p 292

In glycolysis

Fructose 6-phosphate lies within the glycolysis

metabolic pathway In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reac ...

and is produced by isomerisation of

glucose 6-phosphate Glucose 6-phosphate (G6P, sometimes called the Robison ester) is a glucose sugar phosphorylated at the hydroxy group on carbon 6. This dianion is very common in cells as the majority of glucose entering a cell will become phosphorylated in this way ...

. It is in turn further phosphorylated to fructose-1,6-bisphosphate.

References

{{DEFAULTSORT:Fructosephosphate6 Monosaccharide derivatives Organophosphates Phosphate esters Glycolysis

In glycolysis

See also

References