Etidocaine, marketed under the trade name Duranest, is an amide-type

local anesthetic A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general a ...

given by injection during

surgical procedures Many surgical procedure names can be broken into parts to indicate the meaning. For example, in gastrectomy, "ectomy" is a suffix meaning the removal of a part of the body. "Gastro-" means stomach. Thus, ''gastrectomy'' refers to the surgical remo ...

and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.

Synthesis

The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride 2118-12-3(2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide 3984-81-9(3). Alkylation with N-Ethylpropylamine 0193-20-8(4) gives ''Etidocaine'' (5).

References

External links

Duranest
(RxList) Local anesthetics Anilides {{nervous-system-drug-stub