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Enoyl-acyl carrier protein reductase (or ENR) (), is a key enzyme of the type II
fatty acid synthesis In biochemistry, fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell. Most of the acetyl-CoA which is co ...
(FAS) system. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes. : At lower concentrations,
Triclosan Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of act ...
and
Triclocarban Triclocarban (sometimes abbreviated as TCC) is an antibacterial chemical once common in, but now phased out of, personal care products like soaps and lotions. It was originally developed for the medical field. Although the mode of action is unk ...
provide a
bacteriostatic A bacteriostatic agent or bacteriostat, abbreviated Bstatic, is a biological or chemical agent that stops bacteria from reproducing, while not necessarily killing them otherwise. Depending on their application, bacteriostatic antibiotics, disinfect ...
effect by binding to ENR.
Atromentin Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone. Occurrences Atromentin has ...
and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria ''
Streptococcus pneumoniae ''Streptococcus pneumoniae'', or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic (under aerobic conditions) or beta-hemolytic (under anaerobic conditions), aerotolerant anaerobic member of the genus Streptococcus. They ar ...
''.


See also

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Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific) In enzymology, an enoyl- cyl-carrier-proteinreductase (NADPH, A-specific) () is an enzyme that catalyzes the chemical reaction :acyl- cyl-carrier-protein+ NADP+ \rightleftharpoons trans-2,3-dehydroacyl- cyl-carrier-protein+ NADPH + H+ Thus, the t ...
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Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) In enzymology, an enoyl- cyl-carrier-proteinreductase (NADPH, B-specific) () is an enzyme that catalyzes the chemical reaction :acyl- cyl-carrier-protein+ NADP+ \rightleftharpoons trans-2,3-dehydroacyl- cyl-carrier-protein+ NADPH + H+ Thus, the t ...
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Cis-2-enoyl-CoA reductase (NADPH) In enzymology, a cis-2-enoyl-CoA reductase (NADPH) () is an enzyme that catalyzes the chemical reaction :acyl-CoA + NADP+ \rightleftharpoons cis-2,3-dehydroacyl-CoA + NADPH + H+ Thus, the two substrates of this enzyme are acyl-CoA and NADP+, wh ...


References


External links

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