Dimethoxytrityl, often abbreviated DMT, is a
protecting group widely used for protection of the 5'-hydroxy group in
nucleoside
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleoti ...
s, particularly in
oligonucleotide synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence). The technique is extremely useful in current laboratory practice because it provides a rapid and inexpen ...
.
It is usually bound to a molecule, but can exist as a stable cation in solution, where it appears bright orange.
References
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Protecting groups